Pancreatic cancer mRNA vaccine shows lasting results in an early trial Scientists caution that more research is needed, but nearly all of the patients who responded to the personalized vaccine are still alive six years later.

"Pancreatic cancer mRNA vaccine shows lasting results in an early trial: Scientists caution that more research is needed, but nearly all of the patients who responded to the personalized vaccine are still alive six years later."

They'll be Christmas trees again in the fullness of time, according to Vico

Symposia Flexible vs. Programmed? Responses to Environmental Extremes in Mammalian Heterotherms Date: TBD Time: TBD Location: TBD Speakers: Austin Allison, Mallory Ballinger, Malcolm Reimer, Cory Williams T…

Consider attending the American Society of Mammalogist (ASM) Meeting at Norfolk this summer (June 12-15) and Join the symposium co organized by Jessica LaPrice & myself on flexible and inflexible responses in heterothermic species. This will be a fun symposium!

mammalmeetings.org/program/symp...

#Irisin, an #exercise-induced #myokine, counters #obesity via effects on #adipose tissue — but how? With help from Promethion #Metabolic Cages, a Nature #Metabolism study has shown that irisin modulates adipose #IL33 levels to increase #thermogenesis. 🧪
www.nature.com/articles/s42...

Neuronal lipid droplets play a conserved and sex-biased role in maintaining whole-body energy homeostasis - Nature Metabolism In vivo regulation of neuronal lipid droplet formation mediates whole-body energy homeostasis in a sex-specific manner in Drosophila and mice.

Beyond delighted to share our amazing collaboration with Thierry Alquier's lab @alquierthierry.bsky.social on a conserved role for neuronal lipid droplets in regulating energy homeostasis in vivo led by Celena Cherian, Romane Manceau, Danie Majeur, and Colin Miller www.nature.com/articles/s42... /1

Speaker Spotlight: Barbara Kahn @harvardmed.bsky.social
Join us @ #AdiposeBiology Conference in Montreal🇨🇦, Oct 7-9, 2026, to hear from this world leading expert in #adipocyte biology!

🔗Register before the early bird deadline at: adiposebiology.com

@mcgillgci.bsky.social @sablesys.bsky.social

I’m a Nobel Prize-winning immigrant. I can no longer recognize this country. Attacks on science and immigrants are destroying America.

Choice words from Dr. Szostak here.

And while I am no Nobel Prize-winning scientist, I identify with the same quandary as an immigrant, moving here in 2009 and (proudly) becoming a citizen in 2023.

I, too, don't recognize that country anymore 😢🇺🇸🧳🛫.

newsletter.ofthebrave.org/p/im-a-nobel...

Go home Nature, you're drunk

Standardizing the analysis and visualization of human energy expenditure data - Nature Metabolism Adjusting energy expenditure for body composition and visualizing the results are key to understanding the role of energy expenditure in human physiology and disease. Here, we outline specific analysis of covariance modelling and the design of partial residual plots optimized for analysing human energy expenditure data.

#Throwback 🧪

COMMENT | Standardizing the analysis and visualization of human energy expenditure data

JE Galgani, E Ravussin et al

New review article from the lab! In addition to discussing relatively easily studied hovering animals (hummingbirds, nectar bats), we call for further work studying energetics/fuel use in other nectar and fruit-feeders! With @giuliarossi.bsky.social @utscbiology.bsky.social @utsc.utoronto.ca 🦇🧪

This is very very big. Like a big deal and massive cuts. These can’t even be seen as budgetary since you don’t get much savings in the context of trillions budget. They want the US out of R&D out of science research.

Trump Slashed Science Funding. Now the U.S. Could Face a Costly Brain Drain.

www.nytimes.com/2026/04/04/b...

An IL6 variant -174 G-C alters cardiac hypertrophy but not cardiometabolic responses to HFD in mice - npj Metabolic Health and Disease npj Metabolic Health and Disease - An IL6 variant -174 G-C alters cardiac hypertrophy but not cardiometabolic responses to HFD in mice

How do genetic variants of #interleukin-6 (#IL6) contribute to #cardiometabolic disease? With help from Promethion #Metabolic Cages, scientists tested a knock-in mouse model of the IL6 promoter variant #rs1800795. 🧪

buff.ly/GDBusEN

#Respirometry #Metabolism #CVD #HFD

What an All-Star lineup 🤩🤩🤩🤩

An IL6 variant -174 G-C alters cardiac hypertrophy but not cardiometabolic responses to HFD in mice - npj Metabolic Health and Disease npj Metabolic Health and Disease - An IL6 variant -174 G-C alters cardiac hypertrophy but not cardiometabolic responses to HFD in mice

How do genetic variants of #interleukin-6 (#IL6) contribute to #cardiometabolic disease? With help from Promethion #Metabolic Cages, scientists tested a knock-in mouse model of the IL6 promoter variant #rs1800795. 🧪

buff.ly/GDBusEN

#Respirometry #Metabolism #CVD #HFD

I’m thrilled to co-organize the 2nd #AdiposeBiology with @sunglab.bsky.social, Jacqueline Beaudry, and @sablesys.bsky.social in Montreal on Oct 7-9 2026!🇨🇦
🔗 Register now – adiposebiology.com
Hope to see you there! #ABC2026 #Metabolism #Energybalance #ObesityResearch @mcgillgci.bsky.social

World-Leading NIH Metabolic Scientist: Why You Eat 500 More Calories a Day Without Knowing It YouTube video by The Proof with Simon Hill

It was a pleasure to finally have a discussion with Simon Hill about a wide range of topics in nutrition, metabolism, and obesity science!

youtu.be/YWm386QmqFw?...

"Researchers at Stanford University modeled how many people could die or be disabled in 25 years if vaccines for polio, measles, rubella or diphtheria were no longer available."

Polio: 23k paralyzed
Measles: 290k deaths
Rubella: 41k born w/ congenital rubella syndrome
Diphtheria: 138k-1M deaths

Brings back vivid memories of the time in late 1983 when a friend lent me his ninth floor apartment & a rather intense ex GF was listening to this song and started to lean further & further out of the window

Apotropaic, aposematic & chthonic are also good words 😎 - combining them in one sentence is a bit tricky though

Well done. Every news outlet should run a piece like this.

By my age, you will have lost someone to cancer. Or cardiovascular disease. Or another disease NIH funding combats. You will wish you had more time with them. That’s what NIH funding does. Buys us time with the people we love.

#FundNIH.

This is 100% true. Pay the TSA agents.

The moment you look up and see these magnificent creatures, somehow there's a split second of communication and recognition. Impossible to verbalize.

Everything you need to know

You know, I wonder whether some nectivorous ant species hitchhike on hummingbirds?

Some ants will do anything to get at that sweet, sweet nectar

Damn, that's an absolutely fabulous shot. Ants are extremely enterprising creatures.

Picture of a naked mole-rat in a fleece bed

🧵1/15 Delighted to share our study on the naked mole-rat (NMR): a mammal with bizarre thermal biology, notorious longevity, and cancer resistance. But how do NMRs maintain (or fail to maintain) their body temperature? Our latest work digs deep! #ThermalBiology #Thermogenesis

A consensus guide to preclinical indirect calorimetry experiments - Nature Metabolism The authors highlight inconsistencies and divergencies in the literature reporting data on indirect calorimetry for studies on whole-body energy homeostasis, and propose harmonization of standards to facilitate data comparison and interpretation across different datasets.

REVIEW | A consensus guide to preclinical indirect calorimetry experiments 🧪

@bankslab.bsky.social et al

Researchers establish consensus standards for indirect calorimetry experiments