IRE1 drives a homeostatic response to reduced protein influx into the endoplasmic reticulum
www.biorxiv.org/content/10.6...

🎓 Want to do a PhD in cancer biology?
ARC, @universityofgalway.bsky.social offering 2 funded #PhD positions (€25k + fees) starting in 2026.
Focus: #IRE1 signaling in breast cancer.
Apply by 12 Dec 2025
📧 afshin.samali@universityofgalway.ie
#CancerResearch #TNBC #MolecularBiology #PhDPositions

I hope dinner was nice Stefan. Mulranny Park Hotel is one of my favourite places ❤️

Interesting perspective on GRP78 by Amy Lee #ER_Literature
Stress-induced translocation of the endoplasmic reticulum chaperone GRP78/BiP and its impact on human disease and therapy | PNAS www.pnas.org/doi/10.1073/...

Dissecting Branch-Specific Unfolded Protein Response Activation in Drug-Tolerant BRAF-Mutant Melanoma using Data-Independent Acquisition Mass Spectrometry Cells rely on the Unfolded Protein Response (UPR) to maintain ER protein homeostasis (proteostasis) when faced with elevated levels of misfolded and aggregated proteins. The UPR is comprised of three ...

Dissecting Branch-Specific Unfolded Protein Response Activation in Drug-Tolerant BRAF-Mutant Melanoma using Data-Independent Acquisition Mass Spectrometry - Molecular & Cellular Proteomics www.mcponline.org/article/S153...

Optogenetic Clustering of Human IRE1 Reveals Differential Regulation of Transcription and mRNA Splice Isoform Abundance by the UPR Inositol-requiring enzyme 1 (IRE1) is one of three known sensor proteins that respond to homeostatic perturbations in the metazoan endoplasmic reticulum. The three sensors collectively initiate an int...

Optogenetic Clustering of Human IRE1 Reveals Differential Regulation of Transcription and mRNA Splice Isoform Abundance by the UPR
www.biorxiv.org/content/10.1...

Check out this weeks selection of Unfolded Protein Response papers!
biomed.news/bims-unfpre/...
Thanks @biomednews.bsky.social

UM-led study offers hope that existing drug can target metastatic brain tumours A University of Manitoba-led study successfully eliminated breast-cancer derived brain tumours in mice, using a drug to penetrate the brain and eliminate metastatic brain tumours. After testing 8,500

After testing 8,500 drugs, the research team discovered that poziotinib – a drug that already exists and is approved for other cancers – reduced breast cancer brain metastasis tumours in mice after two weeks of treatment. #Medsky #cancerresearch #radyfaculty

Lots of great Unfolded Protein Response papers this week....
biomed.news/bims-unfpre/... thanks @biomednews.bsky.social

🤩I'm sure this is the first of many beautiful images from the Hall Lab!!! 🎉

Happy St Patrick’s Day, Lá Fhéile Pádraig sona daoibh

St Patrick’s Day 2025 – Celebrating Irish change-makers across the globe #stpatricksday YouTube video by Department of Foreign Affairs and Trade, Ireland

Celebrating Irish change-makers across the globe
youtu.be/MeIcN6KJSlU?...

Selection for somatic escape variants in SERPINA1 in the liver of patients with alpha-1 antitrypsin deficiency - Nature Genetics The expansion of clones with distinct SERPINA1 somatic mutants in the livers of alpha-1 antitrypsin deficiency (A1AT) patients is consistent with convergent evolution. These variants interfere with th...

Delighted to share our latest paper on alpha-1-antitrypsin deficiency, in @naturegenet.bsky.social.

A fun collaboration between groups of @matthoare20.bsky.social, @profmarciniak.bsky.social, and Peter Campbell.

@thecimr.bsky.social ky.social, @sangerinstitute.bsky.social, Early Cancer Institute

Woman scientist reading books.

Here it is, the #mitochondrialdisease selection of papers from last week! 📚
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoworld.bsky.social @mitowomen.bsky.social @mitoscientist.bsky.social

Many interesting findings, a few highlights in the comments below! 👇

A BiP-centric view of endoplasmic reticulum functions and of my career After completing my post-doctoral training at the University of Alabama, Birmingham and a brief period on the faculty there, I joined the Department o…

Fantastic article from Linda Hendershot—an incredible scientist and one of the most supportive and inspiring researchers I've had the pleasure of meeting.
www.sciencedirect.com/science/arti...

Photo of Hugh Kearns, announcing Sam Weiner Distinguished Visitor Awardee QR code to register

Hugh Kearns @umanitoba.bsky.social April 7 Bannatyne Campus, April 10 at FG
7 secrets to research success QR code for details

This weeks selection of Unfolded Protein Response papers
biomed.news/bims-unfpre/... @biomednews.bsky.social

a man wearing sunglasses and a white tank top says " a little bit of magic dust " ALT: a man wearing sunglasses and a white tank top says " a little bit of magic dust "

Now to sprinkle the last ingredient of a little magic dust over this grant…….third time lucky?🤞🤞

Past few weeks of Unfolded Protein Response papers! #ERStress @biomednews.bsky.social
biomed.news/bims-unfpre/...
biomed.news/bims-unfpre/...
biomed.news/bims-unfpre/...

@ericchevet.bsky.social thats what weekends are for 🤣

After a long delay time to catch up on Unfoled Protein Response related papers! @biomednews.bsky.social
biomed.news/bims-unfpre/...
biomed.news/bims-unfpre/...
biomed.news/bims-unfpre/...
biomed.news/bims-unfpre/...
biomed.news/bims-unfpre/...
biomed.news/bims-unfpre/...

Come be my colleague! We are hiring very broadly in cancer biology. Great colleagues and department, lots of support, sure the winter is cold but our hearts are warm!

🚨We're hiring! 🚨

BMG is seeking an Assistant/Associate Professor with expertise in Cancer Biology—focusing on genetics and/or biochemistry.

📅 Application review begins March 31, 2025.

🔗More info: viprecprod.ad.umanitoba.ca/DEFAULT.ASPX...

Great opportunity for an Assistant/Associate Professor position in #CancerBiology in the Department of Biochemistry & Medical Genetics at the University of Manitoba. Supportive environment and Winnipeg is a great and affordable city!
bit.ly/4gKnmnS

ER stress peeps I have a question - is there a paper that demonstrates p-PERK ab are not always a reliable method to detect PERK activation? I have a vague recollection of a paper but can’t seem to find it….

The University of Rennes is recruiting an assistant professor (Maître de Conférence) in bioinformatics with a research activity in our unit (oss-clcc.univ-rennes.fr) - if you seek for some information regarding the research them please DM me

Experience Postgrad Life Sciences in @cambridgebiosci.bsky.social
Paid 8-week research internships, for undergraduates in their penultimate year at a UK/Irish university. Aimed at talented students who might not otherwise feel they can easily access summer research opportunities.

🌟 Registration is now OPEN for the #FASEB Endoplasmic Reticulum Conference 2025 #ERSRC! 🎉 Join us June 8-12, 2025, in Melbourne 🏖️, FL, for cutting-edge science and networking.

Check out the program and register here 👇

events.faseb.org/event/endoplasmic-reticulum-function-disease

Proteolethargy……yup that describes how I feel this week 😂

Ooh cool, can I be added? 🇨🇦🍁