Announcement for a lecture by Clemens Plaschka from Vienna's Research Institute of Molecular Pathology on mRNA packaging and export, scheduled for Monday 27th April at 11am BST.

Don’t miss next week’s #LMBSeminar from Clemens Plaschka (@plaschkalab.bsky.social), Senior Group Leader at IMP, Vienna.
Beginning at 11am (BST) on Monday 27 April, Clemens will join us to discuss ‘Mechanisms of mRNA packaging and export’
Visit our website for more info: mrclmb.ac.uk/news-events/...

Three-year funded postdoctoral fellowship for scientists returning after a 12-month career break, deadline May 17, 2026.

The LMB is proud to launch the Career Returner Fellowship, a three-year, fully funded postdoc placement for scientists who have had a career break of over 1 year.

Applications are open now!

More details: mrclmb.ac.uk/careers-and-...

Please share this post with anyone who may be interested!

Dimerisation and twist reversal of the Lewy fold in alpha-synuclein mutants with Parkinson's disease and dementia.

Together with Yang Yang (now at @vai.org) and Michel Goedert. 🥳

www.biorxiv.org/content/10.6...

Composite cryo-E M density map of the yeast K M N junction complex, showing the structure and interactions of K M N junction complex.

Happy to see our paper describing cryo-EM structures of the budding yeast KMN kinetochore complex published in @jcb.org! Our structure reveals how an important hub mediates and regulates assembly of the machine that segregates chromosomes. #cryo-EM @mrclmb.ac.uk

🔗 rupress.org/jcb/article/...

I am excited to share our most recent work collaborating with @centriolelab.bsky.social and @stearnslab.bsky.social to look at the ciliary base of mammalian multiciliated cells w/ cryo-ET, XL/MS, and U-ExM www.biorxiv.org/content/10.6...

Happy to share our latest work spearheaded by super talented PhD student Muyang Ren now out as a bioRxiv preprint.

'Motile ciliophagy promotes ciliary recycling under stress'

www.biorxiv.org/content/10.6...

Our latest @biorxivpreprint.bsky.social: "Prion-like transmission of human tau strains in the mouse brain" 🥳

With Michel Goedert and Masato Hasegawa.

www.biorxiv.org/content/10.6...

Announcement for a lecture by Clemens Plaschka from Vienna's Research Institute of Molecular Pathology on mRNA packaging and export, scheduled for Monday 27th April at 11am BST.

On 27th April, we’ll be welcoming Clemens Plaschka back to the LMB to present an #LMBSeminar on ‘Mechanisms of mRNA packaging and export’
Clemens, previously an LMB postdoc, is now a Senior Group Leader at IMP, Vienna - @plaschkalab.bsky.social.
Talk details: mrclmb.ac.uk/news-events/...

It's a big day for our team. Excited to share the launch of the Thermo Scientific™ Glacios™ 3 Cryo-TEM, our latest 200 kV #cryoEM platform. High-performance imaging with the Thermo Scientific™ READY™ System that can lower installation time and infrastructure costs.

Learn more: ter.li/alac5m

Check out our first lab preprint: A real team effort to understand the Plasmodium GAPM proteins, which form part of a essential bridge between the parasite's cytoskeleton and motility apparatus. Below is a sneak peek of some beautiful microscopy - light and electron! www.biorxiv.org/content/10.6...

Extended this (map_salami) a bit - added a movie option which will generate a labeled movie (1080p or 4k) transitioning between all scenes, with a short rocking motion at each scene for depth perception:

So well deserved. Congrats @vcmentowski.bsky.social !!

Big congrats to our SFB alumna @vcmentowski.bsky.social on receiving the Bayer Pharmaceuticals PhD Award! Her work (previously also conducted in @andrea-musacchio.bsky.social's lab) reveals how CENP-E orchestrates kinetochore corona assembly and links it to mitotic checkpoint signaling. 🎉

Proud to share the yeast telomerase structure, led by the talented @hongmiaohu.bsky.social in collaboration with the Wellinger and Chartrand labs. Discovered 37 years ago and took us nearly 7 years but totally worth the wait 😍.
www.science.org/doi/10.1126/...
www.youtube.com/watch?v=gFE4...

Led by Investigator Scientist @hongmiaohu.bsky.social, @kellythd-nguyen.bsky.social’s group in the LMB’s Structural Studies Division have produced the first ever structure of telomerase from yeast.
Read more here: mrclmb.ac.uk/news-events/...
#LMBResearch #cryoEM 🧪

My first PhD student‘s, Kavan Gor, paper on 5-color single-molecule imaging of co-transcriptional RNA folding is out in @science.org Advances!

He finds how RNA modification enzymes, antisense oligonucleotides and ribosomal proteins re-route nascent RNA folding.

See more details in EMBL post below!

Eight individuals wearing matching blue shirts posing in front of a science-themed poster in a room.

A person in a red coat looks through a microscope on a table covered with informational pamphlets while a man stands nearby in a yellow-walled room.

Woman in a navy shirt gesturing while discussing a topic with a person wearing a blue jacket.

Person wearing an LMB (Laboratory of Molecular Biology) t-shirt engaging in conversation at an indoor event with others around.

We had a fantastic time meeting so many people at the @cambridgebiocampus.bsky.social Career Fair earlier this month.
Couldn’t make it?
Visit our website to get a taste of life at the LMB and see our current vacancies: mrclmb.ac.uk/careers-and-...

📣 Physicists and engineers: apply your experimental skills to biology! Join the group of Katerina Naydenova @imprs-lm.bsky.social for a #PhD to develop new technologies that enable answering fundamental biological questions. Apply NOW!

Happy to share my first adventure in #TeamTomo in collaboration with the talented @inaharasimov.bsky.social. It was a fun experience experience with a lot of learning along the way.

Delighted to announce the posting of our latest preprint, which links stress-induced relocalisation of multiple organelles by dynein to adaptive changes in gene expression in the nucleus (1/n) 🧵

www.biorxiv.org/content/10.6...

We're excited to announce the beta-release of #RELION-5.1! 🥳 This release has important updates on our #amyloid processing pipeline, as described in this preprint: doi.org/10.64898/202... There are also some tweaks for #teamtomo.

#OpenSoftwareAcceleratesScience

Have a look at our new structure of co translational folding in yeast. This is collaborative work initialized by the Rospert lab from the @uni-freiburg.de. Structural work has been done by the amazing @lgrundmann.bsky.social Stay tuned for the next ribosome paper from him, following very soon.

An Asgard archaeon with internal membrane compartments

Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!

www.biorxiv.org/content/10.1...

Structure and assembly of the A-C linker connecting microtubule triplets in centrioles Multiscale cryo-EM of centrioles reveals the structure and polymorphism of the A-C linker connecting microtubule triplets.

Congrats🥳 to @mike-wieczorek.bsky.social, Bin Cai, and our former lab member Jingwei Xu @xujwet.bsky.social to their multiscale imaging 🔬 story of the centriolar AC linker #teamtomo
www.science.org/doi/10.1126/...

The mechanistic basis of cargo selection during Golgi maturation Resident proteins of the Golgi recycle in vesicles and the protein GOLPH3 enables the COPI vesicle coat to accomplish this.

The mechanistic basis of cargo selection during Golgi maturation. From Rebecca Taylor, @katciazynska.bsky.social, @jggkaufman.bsky.social & @grigorytagiltsev.bsky.social at @mpibiochem.bsky.social with David Owen and Sean Munro's group @cellbiol-mrclmb.bsky.social | www.science.org/doi/10.1126/...

Nenad Ban ETH Zürich Ribosome Upside Down: Co-translational Protein Biogenesis at the Tunnel Exit Wednesday 17th September at 11am (BST)

TOMORROW – Nenad Ban from ETH Zürich will be joining us to discuss ‘Ribosome Upside Down: Co-translational Protein Biogenesis at the Tunnel Exit’.
Don’t miss this fantastic #LMBSeminar, beginning at 11am (BST).
More info: www2.mrc-lmb.cam.ac.uk/news-and-eve...

Photograph of Sven Truckenbrodt wearing lab coat in laboratory setting.

LMB welcomes @sventruckenbrodt.bsky.social as a new Group Leader in our Neurobiology Division!
Sven will develop molecular brain mapping, harnessing expansion microscopy & molecular biology methods to better understand the neural basis of behaviour.
www2.mrc-lmb.cam.ac.uk/the-lmb-welc... #LMBNews

The BUB1 and BUBR1 paralogs scaffold the kinetochore fibrous corona The kinetochore fibrous corona docks on CENP-E and a second elusive receptor identified as the checkpoint protein BUB1.

Excited to share our new paper! 🎉
The BUB1 and BUBR1 paralogs scaffold the kinetochore fibrous corona
www.science.org/doi/10.1126/...
Very thankful to @andrea-musacchio.bsky.social for his mentorship and support over the years.

Sub-cellular chemical mapping in bacteria using correlated cryogenic electron and mass spectrometry imaging

Congrats Hannah Ochner and authors on this important paper! Strong collaboration with @kiranrpatil.bsky.social

www.biorxiv.org/cgi/content/...
@mrclmb.bsky.social @wellcometrust.bsky.social

Excited to see this work published online at @cp-cell.bsky.social today!

www.cell.com/cell/fulltex...