SuFEx-based antitubercular compound irreversibly inhibits Pks13 - Nature A preclinical covalent compound, CMX410, contains a aryl fluorosulfate warhead that targets the acyltransferase domain of Mtb Pks13, an essential enzyme in cell-wall biosynthesis, making it a pro...

🧬 New Nature study: CMX410 shows promise as a novel TB drug targeting #Pks13, effective even against drug-resistant strains. This could help shorten long TB treatments.

🔗 www.nature.com/articles/s41...

#Tuberculosis #GlobalHealth #DrugDiscovery

Accelerating tuberculosis diagnosis in Mozambican prisons using digital chest X-rays with computer-aided detection: a longitudinal, comprehensive health intervention - BMC Global and Public Health Background Mozambique has a high burden of tuberculosis (TB) and in 2021, an estimated 18,000 persons with TB nationwide were not diagnosed. Estimates suggest that globally 47% of TB disease in prison...

🚨 AI + digital X‑rays detect more TB in Mozambique prisons

A 2026 study found AI-assisted chest X‑rays outperformed symptom screening and improved linkage to treatment and preventive care, helping close diagnostic gaps.

🔗 bit.ly/3TBmoz

#Tuberculosis #Mozambique #GlobalHealth #AIinHealth #EndTB

Un estudio asocia el conflicto armado en Colombia con más casos y mortalidad por tuberculosis - ISGLOBAL | Manhiça Tuberculosis Initiative (MTBI) 📒 New evidence links Colombia’s armed conflict with higher TB incidence and mortality in affected municipalities. The study, worked on by various Manhiça Tuberculosis Initiative (MTBI) members, shows...

🌎Colombia’s armed conflict fuels TB: more cases, more deaths. Displacement and disrupted care put communities at risk. We must keep health services running. 🔗 www.linkedin.com/posts/manhi%...

World TB Day 2026 - Yes! We can End TB! Led by countries. Powered by people. World TB Day 2026: Yes! We can end TB: Led by countries, powered by people.

WHO has launched the 2026 World TB Day theme: “Yes! We can End TB!” The focus is stronger country leadership, increased investment, and faster rollout of new diagnostics. Ending TB is achievable with sustained action.

www.who.int/campaigns/wo...

#EndTB #PublicHealth

Patients’, caregivers’ and healthcare workers’ perspectives on integrating anxiety care in tuberculosis services in Pakistan: a qualitative interview study - BMC Psychology BMC Psychology - Up to 80% of active tuberculosis (TB) patients experience anxiety, threatening their treatment outcomes. The National TB Control Programme in Pakistan currently only provides...

🦠 Anxiety is common in drug-sensitive TB but rarely addressed in routine care. A Pakistan study shows patients rely on self-coping, providers lack training, yet there’s strong support for integrated mental health care. Feasible model: sessions during TB visits.
🔗 link.springer.com/article/10.1...

TB doesn’t stay in prisons.
Prisons have TB rates 10–20× higher than the general population, with latent TB affecting ~40–50% of incarcerated people in many settings. These facilities act as reservoirs that fuel community transmission.

#TB #PublicHealth #PrisonHealth #GlobalHealth

Bioequivalence of C-reactive protein in fingerprick blood and serum measured using the point-of-care LumiraDx test for tuberculosis diagnosis in exposed contacts C-reactive protein (CRP) is recommended to screen people living with HIV (PLWH) for tuberculosis (TB). LumiraDx is a portable platform that uses finge…

🧪 #CRP testing for TB contacts: fingerprick = serum ✅

1,034 contacts studied using #LumiraDx: strong agreement, 77% sensitivity at WHO cutoff, serum storage -80°C didn’t affect results ❄️

Read study: www.sciencedirect.com/science/arti...

#Tuberculosis #TBScreening #GlobalHealth

⚠️ Flooding in Mozambique is disrupting transport and access to care. For people with TB, treatment interruptions raise serious risks. Our team is on the ground keeping TB services running. Every dose, every patient counts. #TBcare #FloodResponse #Mozambique

📍 Last week, MTBI joined the NUS–Lancet PRIME Commission on Pandemic Justice in Singapore, bringing together global experts to reimagine equitable, community-centered pandemic preparedness. Thanks to Helena Legido-Quigley, The Rt. Honorable Helen Clark, NUS & The Lancet Group!
#PublicHealth #TB

Seasonality of TB in Mozambique 📆
Globally, TB often peaks in spring/summer, but local patterns differ. In Maputo (2011–2016), TB notifications varied by quarter, yet models found no significant seasonal effect. Climate still shapes spatial TB risk nationwide.
#TB #Mozambique

💵 WHO warns that global progress against tuberculosis is at risk. TB still affects 10.7M people and causes over 1.2M deaths each year. Funding remains far below targets, threatening recent gains. Sustained investment is critical to end TB.
#EndTB #GlobalHealth #WHO

Happy Holidays and Happy New Year from the @mtbi.bsky.social team! Boas festas e um feliz ano novo! 🎆

Seasonality of tuberculosis - PubMed The observation of seasonality leads to assume that the risk of transmission of M. tuberculosis does appear to be the greatest during winter months. Vitamin D level variability, indoor activities, seasonal change in immune function, and delays in the diagnosis and treatment of tuberculosis are poten …

❄️ As winter arrives in the Northern Hemisphere, it’s a good time to revisit the seasonality of tuberculosis. Research shows TB transmission may increase during winter months due to indoor crowding and reduced sunlight, with diagnoses peaking later.
pubmed.ncbi.nlm.nih.gov/21572609/

Estimating the Accuracy and Additionality of TB-LAM to Diagnose TB in Children Without HIV (AccuLAM) Abstract. New diagnostic tests and alternative samples to diagnose tuberculosis in children are needed to tackle the diagnostic gap of pediatric tuberculos

New research in Clinical Infectious Diseases: the AccuLAM study assesses the accuracy and added diagnostic value of TB-LAM for detecting TB in children without HIV, an important step toward improving pediatric TB diagnosis.

academic.oup.com/cid/advance-...

#Tuberculosis #GlobalHealth

During World Science Day for Peace and Development, Dr. Dinis Nguenha from CISM shared that using the #Truenat portable molecular diagnostic system enabled 82% of TB patients to start treatment on the same day of diagnosis, improving care and reducing delays!

👏 Dr. Belén Saavedra Cervera (ISGlobal & CISM) wowed audiences at the XXIX Jornadas sobre Tuberculosis 2025, presenting key findings on TB transmission in Manhiça through molecular epidemiology.

Thanks to #CoMB, #uiTB & #fuiTB!

🗨️ Our PhD student, Salome Valencia, presented today at the XXIX Jornadas Internacionales sobre Tuberculosis 2025, hosted by #CoMB, #uiTB & #fuiTB. She explored how armed conflict and social inequality shape #TB in Colombia. Grateful to all for fostering these vital discussions!

TB isn’t a disease of the past — it’s still one of the world’s top infectious killers (WHO, 2024).
❌ Not limited to certain countries
❌ A positive test ≠ contagious
✅ TB is curable, but stigma + myths slow progress.
#Tuberculosis #GlobalHealth

From new WHO guidance on TB & diabetes to innovations workshops, climate frameworks, and global commitments, 2025 is a pivotal year in the fight to #EndTB. Progress is happening, but action must continue. 🩺

#GlobalHealth

Intensified Treatment of Tuberculous Meningitis in Adults: A Systematic Review and Meta-analysis - PubMed Current clinical trial evidence does not support the use of intensified TBM treatment in adults. However, these analyses are limited by diverse TBM case definitions, absence of MRC grading at enrollme...

New meta-analysis finds no clear mortality benefit from intensified treatment regimens (ie. high-dose rifampicin, fluoroquinolones) for #tuberculous #meningitis in adults. More consistent, high-quality trials needed. 📚 pubmed.ncbi.nlm.nih.gov/41064692/

Enhancing tuberculosis treatment support: A thematic analysis of interactive messages in a digital adherence technology trial to identify needs, challenges, and strategies for improvement - PubMed This study highlights the importance of personalized, empathetic communication, and reliable technology to enhance the effectiveness of DATs. Future DAT solutions should prioritize technological relia...

New study in PLOS ONE analyzes 255 messages between TB patients & treatment supporters using digital adherence tech (DATs).

Beyond reminders, patients need empathy, support & better usability.

📖 pubmed.ncbi.nlm.nih.gov/40705794/

#TB #mHealth #DigitalHealth

Costs of 4 Months of Rifampin Versus 2 Months of Double-dose Rifampin for Tuberculosis Infection: Post-Hoc Analysis of a Phase 2b Randomized Trial - PubMed Most costs associated with TPT are due to medications and the baseline treatment initiation visit. TPT regimens requiring fewer follow-up visits may reduce overall cost, but the magnitude of this redu...

🩺New study compares 4R10 vs 2R20 regimens for latent TB. No major cost difference, but meds + follow-ups are biggest drivers. Fewer visits could cut costs, depending on setting.
🔗 pubmed.ncbi.nlm.nih.gov/40980570/

#TB #TPT #GlobalHealth #PublicHealth

🧬 TB remains one of the world’s top infectious killers.
Where, in your opinion, should innovation funding go next?

🟦 Diagnostics
🟦 Shorter treatments
🟦 Vaccines
🟦 Health systems

🌐 Read the WHO Global TB Report 2024: www.who.int/teams/global...

#TB #GlobalHealth #InfectiousDiseases #WHO

🩺 WHO now recommends a 6-month all-oral regimen for drug-resistant TB: shorter, safer, and easier to complete. A major step forward in global TB care.

📄 Full update: www.who.int/news/item/15...

#TB #GlobalHealth

Funding cuts jeopardise global fight against tuberculosis, WHO warns The UN World Health Organization (WHO) warned on Wednesday that severe funding cuts – particularly in the United States – are threatening decades of progress in the fight against tuberculosis (TB), st...

🧠 UN: Children face a “new era of crisis.” For TB, this means more gaps in #care, fragile systems, and kids left behind. We can’t end #TB without reaching the most vulnerable.

🔗 news.un.org/en/story/202...

#EndTB #ChildHealth #GlobalHealth

Analysis of risk factors of low cardiac output syndrome after pericardiectomy for tuberculous constrictive pericarditis: A retrospective study Low cardiac output syndrome (LCOS) is the leading cause of death after cardiac surgery. Studies have shown that 24% of postoperative mortality in pati…

❤️ On #WorldHeartDay, a reminder: #TB can affect more than lungs, it can influence hearts.

New research shows 1 in 5 patients with tuberculous pericarditis develop deadly heart failure post-surgery. Early care matters.

🔗 www.sciencedirect.com/science/arti...

#EndTB #HeartHealth

Sex differences in the risk of Mycobacterium tuberculosis infection: a systematic review and meta-analysis of population-based immunoreactivity surveys Men have higher M tuberculosis immunoreactivity risk than women, which is likely to be a key driver of the sex differences in global tuberculosis morbidity and mortality. This difference could be due ...

🩺 New Lancet study: Men are ~1.7x more likely than women to be infected w/ #TB due to biology and gendered factors.

Question for you: How can we design TB strategies that reflect real sex & gender differences without oversimplifying?

🔗 www.thelancet.com/journals/lan...

#GlobalHealth #HealthEquity

New NEJM study shows 3 oral, 9-month regimens are noninferior for rifampin-resistant #TB. A win for patient-centered care + policy updates.
🔗 www.nejm.org/doi/full/10....

#TB #GlobalHealth #HealthPolicy #InfectiousDisease

Integrated care for tuberculosis and lung health In 2023, tuberculosis claimed approximately 1·3 million lives,1 providing a stark reminder of the persistent inequities and widening gaps in access to tuberculosis services and care worldwide. Tubercu...

🧠Rethinking TB care: Integration isn’t a burden; it’s a cost-effective, people-centred strategy. A new @thelancet.com article makes the case for linking #TB, lung health & shared risks.

🔗 www.thelancet.com/journals/lan...

#Tuberculosis #LungHealth #GlobalHealth #PublicHealth #TheLancet

Performance of a Novel Stool Quantitative Polymerase Chain Reaction Assay for Pediatric Tuberculosis Detection in Sub-Saharan Africa AbstractBackground. Children have paucibacillary tuberculosis and cannot provide expectorated sputum. Invasive specimen collection, by gastric aspiration o

🧪 New stool #qPCR test improves pediatric #TB detection in high-burden settings! It's #non-invasive, has a high specificity, and improves pediatric TB detection where sputum or gastric sample collection is challenging.

🔗 academic.oup.com/jpids/articl...

#PediatricTB #GlobalHealth #Diagnostics