Our latest work on shape-programmable tissues is out in @science.org. By positioning topological defects in cellular nematics, we encode frustrated 2D force fields that relax into predictable 3D shapes. Collaboration with Marino Arroyo’s lab, led by @pauguillamat.bsky.social at @ibecbarcelona.eu.
An egg-cellent use of micropatterning 🙌
Interested in doing a PhD in tumor mechanobiology?
At Université Paris-Saclay, the upcoming PhD selection process is open, and I’m looking to put forward a candidate to join my lab.
If you’re excited about uncovering how mechanical signals regulate tumor progression, please get in touch!
Sometimes, the only way to build back up is to let everything fall apart. This is certainly true at the cellular level. www.quantamagazine.org/break-it-to-...
We‘re looking for a motivated Master student to join our team!
Do you want to optogenetically control metabolic activity to see how metabolism affects patterning and morphogenesis? 💡🧫🧬🔬
Then please apply!
#optogenetics #metabolism #devbio #hESCs
Please RT. Thank you!🙏
How convenient - this tree already comes with ornaments!
Get into the holiday spirit with this beautiful cell tree by @oozguc.bsky.social from @ibecbarcelona.eu. This beautiful fusion of science and art was made using our Lamin B1 stem cell line - complete with pink nuclei ornaments!
I am putting together a collection of video-protocols we (will) use in tissue mechanics research🌀
I hope to help consolidate established methods, but also showcase a few up-and-coming ones in our blooming field.
Abstract submission by March 2026! Get in touch✨
#JoVETissueMech
#ReproducibleTissueMech
For this festive season, I’m sending friends and family something a little different: postcards straight from the microscope. 🔬
Featuring my hiPSC Christmas tree from last year and a hiPSC colony turned into a festive bauble, with wishes for a season that’s festive at every scale. 🎄
You know that sinking feeling 🥶 when it was all going well, but this past month your cells stopped attaching to their protein patterns? Could it be the change of season...? 🫠
Don't know what I mean and it all works? Help a friend! Get your protocol on video🎄🎁
#JoVETissueMech
#ReproducibleTissueMech
Meet the Epithelial Mechanics Fan Club @epimechfc.bsky.social
Nimesh Chahare @onenimesa.bsky.social and Julia Eckert @juliaeckert.bsky.social introduce us to the Epithelial Mechanics Fan Club.
Learn how you can get involved with this community: focalplane.biologists.com/2025/12/04/e...
#LivingArchitectures
We put cells and cytoskeleton filaments on the architecture of the musée d'Orsay.
www.musee-orsay.fr/fr/agenda/ev...
Scientists of the #CytoMorphoLab adapted their protocols to illustrate the questions that keep them awake at night.
-> Two shows on the 24th and 25th of January.
Group photo of Workshop attendees
Thank you to organisers Alex Dunn, @zevgartner.bsky.social, @adrianjacobo.bsky.social and Matthew Kutys and everyone who joined us for our Workshop on New Technologies for Studying and Reprogramming Development.
#BiologistsWorkshops
biologists.com/workshops
A gourd-geous image of our lamin B1 cell line for your Halloween cell-ebrations! 🎃🧬
📸 Thanks to @oozguc.bsky.social for sharing this unbe-leaf-able shot!
#FluorescenceFriday
When #halloween meets #FluorescenceFriday 🎃
📣Announcing the 4th edition of the EMBL‑IBEC Conference on “Engineering Multicellular Systems”, taking place 11–13 March 2026 in Barcelona. Exploring organoids, mechanobiology, embryo models, organ-on-chip systems, multiomics and more. Abstracts open now!
events.ibecbarcelona.eu/embl-ibec-co...
1/ 🎉Excited to share our new preprint @vignjeviclab.bsky.social @davidbrueckner.bsky.social :
"Self-organization of tumor heterogeneity and plasticity"
biorxiv.org/content/10.1...
Tumor heterogeneity and plasticity drive metastasis and relapse. How is tumor patterning coordinated?
A thread👇
Check out the preprint of my main work in the lab of @xaviertrepat.bsky.social @IBECBarcelona. Many thanks to all the people involved!
Cartoon of a scientist peering through a microscope saying "Whoaah!!!". Title says "The best part of Science is knowing, for a moment, something that nobody else in the world knows."
Really just had something like this feeling this afternoon. It’s the high that keeps you coming back for more
On cell extrusion in the #intestine!
After 80 years of observations, we finally took a deeper look thanks to 2D #organoids. We report:
3D #forces, #extrusion still only in the villus even without curvature, #lamellipodia generate 3D force.. and more. Have a look!
www.biorxiv.org/content/10.1...
Have you ever thought about inflating tissues?
Or maybe quickly deflating those inflated tissues?
New #EpithelialMechanics pre-print: doi.org/10.1101/2025...
🧵 with pressure control, multiscale buckling, controlled wrinkling
🚨 Second preprint of the week!
We uncover the multiscale dynamics of active viscoelastic buckling in epithelia.
We harness these mechanical instabilities for synthetic morphogenesis.
Led by @onenimesa.bsky.social 🙌. Theory by Marino Arroyo etal. @ibecbarcelona.eu
www.biorxiv.org/content/10.1...
New preprint out! We show how cellular nematic order can be harnessed to program tissue-wide force fields and guide 3D shape transformations.
The tissue morphogenesis logic, now engineered into living, programmable materials.
www.biorxiv.org/content/10.1...
#ActiveMatter #TissueEngineering
highly recommended! 👇
A ‘Cell-estial Bloom’ of human induced pluripotent stem cells (hiPSCs) flourishes on a micropatterned island. This image presents a colony of live hiPSCs, with fluorescently labeled Lamin B delineating the nuclear lamina within each cell. Acquired with a Zeiss LSM 880 Airyscan microscope, this maximum intensity projection is enhanced with depth-coded coloring to reveal the captivating three-dimensional landscape.
Featured image with Özge Özgüç: the Node–FocalPlane image competition
Find out more about @oozguc.bsky.social and the story behind "Cell-estial bloom", which won the image competition we organised with @focalplane.bsky.social:
thenode.biologists.com/featured-ima...
From Turkiye’s Children’s Day to San Jordi in Catalonia, today is all about love, knowledge, and the future.
@ibecbarcelona.eu turned my microscopy image into a bookmark for the occasion🎈
23 Nisan kutlu olsun & Feliç Diada de Sant Jordi!
How do hydraulic forces impact critical processes such as tissue integrity, cell fate decisions, and embryo development?
Hydraulics studies how fluids move and exert forces.
Join me in exploring few articles on hydraulics in #EpithelialMechanics
We’re looking for PhD students to join the lab! 🧫🧑🔬
Curious about how metabolic processes shape patterning and morphogenesis? Enthusiastic about stem cell models for human development? - Then apply through the VBC PhD program! training.vbc.ac.at/phd-program/
‼️Deadline: April 15‼️
Cartoon of techniques to apply one-dimensional, in-plane or volumetric cell compression in vitro.
In their Review, Laura Faure, Valeria Venturini @valeriaventurini.bsky.social and Pere Roca-Cusachs discuss the biological contexts of cell mechanical compression, the associated mechanisms and the experimental systems engineered to compress cells in vitro.
journals.biologists.com/jcs/article/...
"Cell-estial bloom" Image from Özge Özgüç: A ‘Cell-estial bloom’ of human induced pluripotent stem cells (hiPSCs) flourishes on a micropatterned island. This image presents a colony of live hiPSCs, with fluorescently labelled Lamin B delineating the nuclear lamina within each cell. Acquired with a Zeiss LSM 880 Airyscan microscope, this maximum intensity projection is enhanced with depth-coded coloring to reveal the captivating three-dimensional landscape.
"Dancing actinotroch" by Allan Carrillo-Baltodano: Actinotroch larva of a phoronid worm with phalloidin shown in yellow and acetylated tubulin in magenta. Imaged with a Zeiss LSM 800 at 10 x magnification.
"Who’s active?" by Julia Peloggia de Castro: The image depicts a zebrafish embryo at 9 hours post-fertilisation on a lateral view. Cells are stained with MitoTracker, which labels active mitochondria, and cell membranes are labelled in cyan with a EGFP transgenic membrane tag. Image was taken using a 20x objective on a spinning disk confocal microscope.
🎉Congratulations to the Top 3 images from the Node–FocalPlane image competition!
1️⃣"Cell-estial bloom" by @oozguc.bsky.social
2️⃣"Dancing actinotroch" by @allancarbal.bsky.social
3️⃣"Who’s active?" by @jupeloggia.bsky.social
thenode.biologists.com/results-from...
@focalplane.bsky.social #biologists100
Thank you🥰🥰
