Excited to share our study on #neutrophils in brain cancers – now online in #Cell!
 
Neutrophils migrate to the #brain #TME in large no's & adopt multifaceted tumor-promoting roles 🧵⬇️
 
🙏 to all in our super team 🧪⚕️, led by Roeltje Maas 🙌
 
Image: @joanagcc.bsky.social
 
www.cell.com/cell/fulltex...

Ok ok if sunrise isn’t big enough then I gotta check out this place in black mountain!

How come nobody has mentioned Sunrise Biscuit Kitchen on Franklin in Chapel Hill?!

🧪🧪 The Immunological Proteome Resource is now on Bluesky as well.

ImmPRes is an open access resource created to provide an in-depth, high quality, quantitative map of the immuno proteome. It integrates immune cell proteomic data generated by quantitative mass-spectrometry.

#immunology #proteomics

Digitize your Biology! Modeling multicellular systems through interpretable cell behavior bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

Thrilled to announce a new preprint developing a new grammar in @PhysiCell to bridge biological, clinical, and systems biology researchers for mathematical modeling of biological systems at scale including integration of single-cell multi-omics data. 1/19 www.biorxiv.org/content/10.1...

Mismatch repair deficiency is not sufficient to elicit tumor immunogenicity
www.nature.com/articles/s41...

Cool paper, thanks @timtriche.bsky.social

🧬🖥️⚕️🔬🧫💊 #immunosky

That made me stop mid scroll 😯

Our lab’s review on antibody drug conjugates just came out in JCI! We discuss some of their immune stimulatory properties and also how they can help create drugs of the future. Check it out here if you’re curious! www.jci.org/articles/vie... 🧪

Gene variant carried by 1 in 5 people may guard against Alzheimer's and Parkinson's, massive study f... An immune-related gene variant has been tied to a reduced risk of Alzheimer's and Parkinson's across a huge, diverse population of people.

🧪 A gene variant found in 20-30% of individuals seems to lessen the risk of Alzheimer's and Parkinson's. Analysis involved data from 176k patients, nearly 2 million controls, and 7k autopsied brains, pinpointing lower risks & reduced abnormal brain proteins.

Welcome @hoadley.bsky.social!

We should get all of UNC's Computational Medicine program on here.

🧪🧬🖥️⚕️🔬🧫💊

Rebecca Barter - An introduction to Python for R Users I have a confession to make: I am now a Python user. Don't judge me, join me! In this post, I introduce Python for data analysis from the perspective of an R (tidyverse) user.

Are you an R user who is interested in learning Python?

This blog from Rebecca Barter introduces Python from an R user's perspective 🧪

www.rebeccabarter.com/blog/2023-09...

Spatial mapping of mitochondrial networks and bioenergetics in lung cancer - Nature A study describing an approach that combines imaging and profiling techniques to structurally and functionally analyse lung cancer in vivo, revealing heterogeneous mitochondrial networks and an a...

Tumors can have diverse mitochondrial charge levels, respiration, and shapes. More cool evidence that we can measure this in vivo in mammals and that it's relevant for health: 🧪

idp.nature.com/authorize?re...

I was amazed that my iPhone could capture the Milky Way and the Big Dipper!

Systems immunology of regulatory T cells: can one circuit explain it all? Regulatory T (Treg) cells play vital roles in immune homeostasis and response, including discrimination between self- and non-self-antigens, containme…

Excited to have this Opinion out! We propose that the diverse functions of Treg cells in health and disease may be interpreted in terms of different dynamical regimes of an immune cell circuit, which provides a powerful framework for analyzing experimental data.
www.sciencedirect.com/science/arti...

System-wide mapping of peptide-GPCR interactions in C. elegans Beets et al. present a system-wide resource of 461 peptide-GPCR couples in C. elegans, revealing binary and complex combinatorial signaling motifs in the peptide-receptor network, which provide insi...

Complexity of the wireless connectome in C. elegans. Important work setting the stage look at biological roles of this signaling in vivo 👏
🧪 #neuroscience
www.cell.com/cell-reports...

“These are the root of the mission of universities, but they could probably use some watering”

Interesting review, does model complexity ⬆️ understanding?

“If classical algorithms are divided from human understanding, they are also divided from data…Machine learning changes this. The “algorithms” are no longer designed by engineers but instead tuned by machines based on large amounts of data”

@danirabaiotti.bsky.social could I be added to the science 🧪 feed? I’m interested in designing new immunotherapies to treat metastatic cancer using natural killer cells!

I hope with all the twitter changes occurring, bluesky can become a source where we can discover new exciting papers.

Also hello bluesky, first post etc. I’m into making new cancer immunotherapies and natural killer cells 🧪

Great point about the awareness around each disease and underlies the need for better screening for both.