Normal neuro-vascular maps of the macular inner-retina. Top half clinical imaging: Topographic analyses from 96 normal eyes for OCT thickness (Trinh et al., 2022b) and 57 normal eyes for OCTA signal (Trinh et al., 2021a), with exclusion of any retinal macular/optic nerve pathology. Common locations of the optic nerve head and retinal blood vessels were excluded from OCT scans (Burke et al., 2024a, 2024b; Tong et al., 2020; Trinh et al., 2020, 2021b, 2022b). OCT layers are depicted on the left using a standardised thickness scale (darker green = greater thickness), while OCTA slabs are depicted on the right using a standardised OCTA signal (darker red = greater OCTA signal). Vascular slab approximations were adapted from Campbell et al. (Campbell et al., 2017). For reference, the RPE-BM (drusen layer) is shown using OCT thickness, and the choriocapillaris is shown using OCTA signal. Bottom half histological imaging: Resin embedded, 100 nm serial section of mid-peripheral retina of aged, normal human eye (87 year old male) with amino acid immunolabelling of GABA, glycine, and glutamate mapped to the red, green, and blue colour channels, respectively, and rod opsin labelling indicated in yellow. The section illustrates the laminar organisation of the inner- and outer-retina for cross-reference with the OCT layers above and the distinct neurochemical signatures of neurons in these layers. White scale bar 100 μm. RNFL, retinal nerve fibre layer; GCL, ganglion cell layer; IPL, inner plexiform layer; INL, inner nuclear layer; OPL, outer plexiform layer; ONL, outer nuclear layer; IS/OS, photoreceptor inner- and outer-segments; RPE-BM, retinal pigment epithelium to Bruch's membrane.
New publication: Inner-Retinal Changes In AMD: Evidence, Mechanisms, and Future Perspectives.
A fun project with Matt Trinh, Michael Kalloniatis, myself, Glenn Yiu, Enrico Borrelli, and Lisa Nivison-Smith
bryanwjones.com/2026/03/inne...
