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Rethinking Early Intervention in Relapsing Multiple Sclerosis: A Closer Look at Long-Term Safety and Efficacy Data for Sphingosine 1-Phosphate Modulators Expert insights on the open-label DAYBREAK study of ozanimod for early relapsing MS: efficacy, long-term safety, and real-world use from...

📖 Long-term data on ozanimod informs relapse reduction, MRI lesion control, and safety considerations clinicians should know.

www.emjreviews.com/en-us/amj/ne...

#MultipleSclerosis #Neurology #AMJNeurology

This article was sponsored by Bristol Myers Squibb and is intended for US neurologists only.

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HIV Post-Exposure Prophylaxis Guidance Updated Updated HIV post-exposure prophylaxis guidelines introduce new PEP regimens, shorten follow-up HIV testing, and refine management after occupational exposure when source patients have undetectable vir...

🧬 Updated HIV PEP guidance trims follow-up testing & reflects undetectable viral loads in occupational exposures.

www.emjreviews.com/en-us/amj/mi...

#AMJNeurology #HIV #PEP #InfectiousDiseases

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Direct Brain Drug Delivery Appears Safe in Pediatric Studies Systematic review finds convection-enhanced delivery in pediatric patients is linked mainly to low-grade adverse events, with no Grade 4 or 5 toxicity, supporting safer investigational CNS therapy del...

🧠💉Pediatric CED appears safe overall according to 12 studies (162 patients) which found mostly Grade 1–2 AEs, and no Grade 4/5 toxicity.

www.emjreviews.com/en-us/amj/ne...

#AMJNeurology #PediatricNeurology

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Understanding Persistent Idiopathic Facial Pain in Practice This commentary on persistent idiopathic facial pain urges balanced dental and neurologic assessment, clearer differential diagnosis with migraine, and pragmatic combined behavioral and pharmacologic ...

🧩 Interdisciplinary guidance redefines persistent idiopathic facial pain as a shared challenge for neurologists and dentists, calling for coordinated assessment and integrated behavioral and pharmacologic care.

www.emjreviews.com/en-us/amj/ne...

#AMJNeurology #ChronicPain #FacialPain

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Achalasia Hospitalizations Reflect Major Decade Shift This U.S. trend analysis of achalasia hospitalizations reports rising POEM adoption more comorbid patients and increasing cost pressures across a decade of inpatient care.

📈 Achalasia hospitalizations surged over a decade. Rising admissions signal burden and care gaps in motility disorder.

www.emjreviews.com/en-us/amj/ne...

#AMJNeurology

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Clinical Drivers of Outcome in Cerebral Malaria Cause-specific mortality patterns in paediatric cerebral malaria revealed multiple distinct immediate causes of death indicating possible dilution of brain-focused therapeutic effects in clinical tria...

🧠 Why do outcomes vary in pediatric cerebral malaria? Researchers found that deaths arise from diverse causes, not just cerebral herniation, but also systemic organ failure, suggesting new directions for targeted interventions.

www.emjreviews.com/en-us/amj/ne...

#AMJNeurology

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Contact Sports and Concussion Affect Brain Structure New imaging data suggest prior concussion alters cortical microstructure and surface area in young athletes, highlighting early neurotrauma effects in contact sports.

🧠 Prior concussion, not just years in contact sport, shows clear ties to altered cortical microstructure in collegiate athletes, hinting at early neurotrauma risk.

www.emjreviews.com/en-us/amj/ne...

#AMJNeurology #SportsMedicine

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Combined Brain Stimulation and VR Improves Attention A single session combining transcranial direct current stimulation and virtual reality mindfulness reduced autonomic arousal and may improve attention control, suggesting potential benefits for cognit...

🧠💡 A new study finds that combining brain stimulation with immersive VR training can markedly improve attention and cognitive control, offering a powerful, non-invasive approach to enhance brain function.

www.emjreviews.com/en-us/amj/ne...

#AMJNeurology #CognitiveHealth #Neurorehabilitation #VR

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Smoking Tied to Faster Huntington’s Decline Analysis of Enroll-HD shows smoking is linked to earlier Huntington’s disease onset in women and faster motor and cognitive decline, supporting cessation advice for HD gene carriers.In Enroll-HD, smok...

🚬 New insight: smoking may accelerate symptom progression in Huntington’s disease, with smokers experiencing a faster decline. Lifestyle counselling could be key to slowing neurological deterioration.

www.emjreviews.com/en-us/amj/ne...

#AMJNeurology #HuntingtonsDisease #Neurodegeneration

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Machine Learning Predicts ICU Readmission After Stroke A retrospective study of 3,348 cerebral infarction patients shows machine learning can predict ICU readmission. Logistic regression performed best and highlighted modifiable clinical predictors for ri...

🧠🤖 ML predicts ICU readmission after stroke. Logistic reg leads (AUC 0.682); signals: steroid exposure, potassium, RBC count to guide follow-up.

www.emjreviews.com/en-us/amj/ne...

#AMJNeurology #Stroke

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Post-Thrombosis Complications May Limit Return to Work Survivors of cerebral venous sinus thrombosis frequently experience chronic headaches, seizures, depression, and cognitive impairment that hinder recovery and return to work.

🧠 New research shows cerebral venous sinus thrombosis (CVST) can lead to lasting neurological and psychiatric effects, including headaches, seizures, and depression, that may prevent many from resuming full-time employment.

www.emjreviews.com/en-us/amj/ne...

#AMJNeurology #Stroke #MentalHealth

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Omega-3s Reduce Inflammation but Not Outcomes in Head Injuries Omega-3 supplementation lowered inflammatory and oxidative stress markers in moderate-to-severe head injury patients but did not improve long-term clinical outcomes, trial results show.

🧠💊 Omega-3 supplements reduced key markers of inflammation and oxidative stress in moderate-to-severe head injuries, but no improvement was seen in long-term recovery outcomes, researchers report.

www.emjreviews.com/en-us/amj/ne...

#AMJNeurology #BrainInjury #Neuroinflammation

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Weeks-Long Brainwave Shift Seen After Parkinson’s Surgery Continuous recordings in Parkinson’s patients reveal that postoperative beta power rises for weeks after deep brain stimulation, offering new insight into the timing of the stun effect.

🧠 Weeks-long brainwave shift seen after Parkinson’s surgery. Beta power continued to rise for more than 3 weeks post-DBS, signaling a need to rethink early programming timelines.

www.emjreviews.com/en-us/amj/ne...

#AMJNeurology #ParkinsonsDisease

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Exploring the Effect of Parkinson’s Therapies on Vision Visual symptoms in Parkinson’s disease may remain largely unchanged despite treatment with levodopa or deep brain stimulation.

🧠 Can Parkinson’s therapies improve vision? Findings suggest levodopa and deep brain stimulation bring little change in reading speed or contrast acuity, with only slight non-significant post-surgical trends.

www.emjreviews.com/en-us/amj/ne...

#AMJNeurology #ParkinsonsDisease

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Sex Differences Shape Huntington’s Disease Progression Sex differences significantly influence Huntington’s disease outcomes, with women showing slower brain atrophy but greater clinical decline as genetic-age risk scores increase.

🧠 Huntington’s disease progression differs by sex. Women retain more brain volume yet experience greater motor, cognitive, and functional decline with rising CAG-age risk. Findings stress tailored management.

www.emjreviews.com/en-us/amj/ne...

#AMJNeurology #Neurodegeneration

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Unexpected Brain Shift Emerges in Oral Disorder Coping behaviors in oral cenesthopathy unexpectedly amplify right-sided brain perfusion, suggesting adaptive involvement of visual processing regions in symptom management, a new neuroimaging study sh...

🧠 Coping behaviors in oral cenesthopathy paradoxically amplify right-sided brain perfusion during symptom relief, with significant changes in regions linked to visual processing, new research reveals.

www.emjreviews.com/en-us/amj/ne...

#AMJNeurology #Neuroimaging #OralDisorders

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Updated Criteria Advance Vascular Dementia Diagnosis Updated VasCog-2-WSO criteria establish a new global standard for diagnosing vascular cognitive impairment and dementia, incorporating biomarkers and imaging to improve diagnostic consistency and earl...

🧠 Updated VasCog-2-WSO criteria reshape diagnosis of vascular cognitive impairment. Incorporating biomarkers and neuroimaging, they create an international framework for consistent dementia assessment.

www.emjreviews.com/en-us/amj/ne...

#AMJNeurology #Dementia

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Global Analysis Reveals Rising Burden of Complex PTSD New global review finds nearly 9 in 100 individuals experience ICD-11 complex post-traumatic stress disorder, underscoring the need for improved recognition, screening, and trauma-informed care worldw...

🌍 Complex PTSD affects almost 9 of every 100 people globally, according to new evidence. The study underscores the scale of the challenge and the need for better trauma-informed strategies.

www.emjreviews.com/en-us/amj/ne...

#AMJNeurology #MentalHealth

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Disease Clusters in Midlife Strongly Predict Stroke Risk Midlife clusters of cardiovascular and metabolic conditions predict ischemic stroke incidence and severity, with renal dysfunction showing the strongest association, highlighting the importance of ear...

🧠 Midlife health patterns reveal life-changing stroke risk...

Renal dysfunction clusters show 3× overall risk, ~5× severe stroke risk.

www.emjreviews.com/en-us/amj/ne...

#AMJNeurology #StrokeRisk

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Females with PTSD Show Working Memory Deficits Women with PTSD showed reduced 2-back accuracy and slower N-back reaction times, with 2-back slowing linked to avoidance and total symptom severity, indicating non-emotional working memory impairment.

🧠 New findings show women with PTSD perform worse on the 2-back working memory task, with slower responses tied to avoidance severity and overall symptoms.

www.emjreviews.com/en-us/amj/ne...

#PTSD #Cognition #Neurology #WorkingMemory #AMJNeurology

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GLP-1 Agonists Show Motor Benefits in Parkinson’s GLP-1 receptor agonists improved motor function in Parkinson’s disease but increased adverse events, according to a new systematic review and meta-analysis, highlighting potential for repurposed thera...

🧠 Can diabetes drugs help Parkinson’s?

A new meta-analysis finds GLP-1 receptor agonists improved motor function in PD, though adverse events were more common. More research is needed.

www.emjreviews.com/en-us/amj/ne...

#AMJNeurology #ParkinsonsDisease #Diabetes #Neurodegeneration

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How Do Breakfast Habits Influence Clinical Depression Risk? A systematic review and meta-analysis found that skipping breakfast increases depression risk by 83%. Regular morning meals may play a preventive role in supporting mental health.

🥣 Could a missed breakfast be influencing your patients’ mental health?
A new meta-analysis links breakfast habits with depression risk.

www.emjreviews.com/en-us/amj/ne...

#Neurology #MentalHealth #AMJNeurology

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Targeted Therapies Offer Hope in Inflammatory Myopathies Advances in classification and treatment of idiopathic inflammatory myopathies highlight the role of biomarkers, interferon-targeted therapies, and novel immunotherapies in improving outcomes.

🧬 Targeted therapies are reshaping care in inflammatory myopathies, offering fresh hope for patients through biomarker-driven and immune-based approaches.

www.emjreviews.com/en-us/amj/ne...

#AMJNeurology #Autoimmune #Myopathy #PrecisionMedicine

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Post-Transplant Cognitive Impairment Lacks Clear Cause Cognitive impairment affects many liver transplant recipients despite resolving hepatic encephalopathy, with no clear single cause identified. Study highlights need for ongoing monitoring and targeted...

🧠✨ Six months after liver transplant, 60% of patients showed cognitive decline, with no single cause found. Highlights need for close, ongoing monitoring.

🔗 www.emjreviews.com/en-us/amj/ne...

#LiverTransplant #CognitiveHealth #Neurology #AMJNeurology #TransplantCare

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Artificial Sweetener Alters Vascular Function in the Brain Erythritol exposure increased oxidative stress and impaired nitric oxide and fibrinolytic signaling in brain endothelial cells, suggesting a potential link to ischemic stroke risk.

🧠 Erythritol, a popular sweetener, may impair brain blood vessel function and reduce nitric oxide signaling, potentially raising stroke risk.

🔗 www.emjreviews.com/en-us/amj/ne...

#AMJNeurology #EndothelialHealth

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Mediterranean Diet Trial Yields Mixed Results A Mediterranean diet improved adherence and modestly reduced weight in older African American adults but did not enhance cognition, according to long-term results from a randomized trial.

🥗 Calorie-restricted Mediterranean diet improves metabolic health, but cognitive results fall short in new trial.

🧠 Still, food for thought in dementia prevention.

#AMJNeurology #BrainHealth #MedDiet

🔗 www.emjreviews.com/en-us/amj/ne...

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Cannabis Use Rarely Precedes Hard Drug Use, Study Finds A large Japanese survey finds little evidence that cannabis leads to harder drug use, challenging the gateway hypothesis and prompting reevaluation of longstanding drug policy assumptions.

🌿🚫 New study challenges the “gateway drug” theory: Only 1 in 200 cannabis users went on to use heroin or meth.

#AMJNeurology #PublicHealth #AddictionScience

🔗 www.emjreviews.com/en-us/amj/ne...

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New Insights into VMAT2 Use for Child Movement Disorders VMAT2 inhibitors improve symptoms in many children with movement disorders, but insurance denials and affordability remain major barriers to treatment access and continuation.

💡New insights into VMAT2 inhibitors offer hope for children with movement disorders. Experts urge caution on timing and safety.

#AMJNeurology #VMAT2 #Tics

Read the story: www.emjreviews.com/en-us/amj/ne...

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New Migraine Treatment Blends Telehealth Approaches Combining behavioral therapy and pharmacologic treatment via telehealth may improve migraine outcomes by increasing access and tailoring care to the complex nature of the disease.

💻🧠 A new model combines behavioral and pharmacologic interventions via telehealth to help optimize migraine outcomes and access.

Explore the findings: www.emjreviews.com/en-us/amj/ne...

#AMJNeurology #Telehealth #MigraineCare #DigitalHealth #ChronicPain

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Potassium, Calcium, and Magnesium Levels Impact Stroke Prognosis A new prospective cohort study finds that high-normal levels of potassium, calcium, and magnesium are linked to reduced risks of death and major disability at 3 months after ischemic stroke, offering ...

🧠 The importance of electrolyte balance in stroke recovery?

Patients with ischemic stroke with higher-normal serum levels of potassium, calcium, and magnesium showed significantly better outcomes at 3 months. Read more: www.emjreviews.com/en-us/amj/ne...

#AMJNeurology @amjreviews.bsky.social

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