📊 Elevated sleep apnea-specific hypoxic burden at diagnosis predicts significantly higher 30-day post-operative mortality and cardiac complications after major non-cardiothoracic surgery.
👉 www.emjreviews.com/en-us/amj/re...
@amjreviews.bsky.social #AMJRespiratory
📖 Editor’s News Pick: Smoking and quitting behaviors vary by socioeconomic position. A new study suggests how to tailor cessation conversations and pathways so support meets patients where they are.
www.emjreviews.com/en-us/amj/re...
#AMJRespiratory #ATS
⏰🫁🔬 NSCLC Phase 3: first 4 immunochemo cycles before 3pm linked to longer survival, with similar safety and a CD8 activation signal.
www.emjreviews.com/en-us/amj/re...
#AMJRespiratory #NSCLC #LungCancer
😮💨🩺 GLP-1s linked to chronic cough.
EHR data (T2D): ~12% higher risk vs other meds. Signal remained after excluding reflux (not causal).
www.emjreviews.com/en-us/amj/re...
#AMJRespiratory #Pulmonology
🫁📊 Never-smoker NSCLC: chronic lung disease linked to ~3× higher odds. Living outside the capital city also showed higher odds.
www.emjreviews.com/en-us/amj/re...
#AMJRespiratory #LungCancer
💰🫁 Durvalumab in LS-SCLC improved survival but ICER hit $383k/QALY, above US $150k threshold. Extrathoracic progression subgroup came close.
www.emjreviews.com/en-us/amj/re...
#AMJRespiratory #LungCancer
💨 Inhalers prescribed for asthma and COPD in the U.S. released nearly 25 million metric tons of greenhouse gases over the last decade, 98% from metered-dose inhalers. Could greener options cut emissions?
www.emjreviews.com/en-us/amj/re...
#AMJRespiratory #ClimateHealth #Sustainability
💉 Tezepelumab treatment enabled many patients to reduce or stop oral steroids without loss of asthma control in a global Phase IIIb study.
www.emjreviews.com/en-us/amj/re...
#AMJRespiratory #Asthma #LungHealth
🫁🧬 Preclinical signal: can lung clots protect? Moderate thrombosis in sepsis ARDS limited endothelial injury via ALOX15-driven lipids.
www.emjreviews.com/en-us/amj/re...
#AMJRespiratory #Sepsis #ARDS
🦠💉 Intranasal vaccine shows early promise against bird flu, priming strong mucosal and systemic immunity and broadening responses across diverse H5N1 clades after an IM booster dose.
www.emjreviews.com/en-us/amj/re...
#AMJRespiratory #InfectiousDiseases
💨 New data show lung cancer survival has risen to nearly 30%, driven by screening and precision medicine. Yet experts caution that funding cuts could slow advances in prevention, diagnosis, and equitable access to care.
www.emjreviews.com/en-us/amj/re...
#AMJRespiratory
💨 Inspiratory muscle training appears to enhance exercise tolerance in adults with post-COVID-19 syndrome. Trials show gains in inspiratory strength, diaphragmatic thickness, and six-minute walk distance.
www.emjreviews.com/en-us/amj/re...
#AMJRespiratory #PostCOVID
🧬 Understanding stubborn lung infection: a new study reveals how M. avium frequently reinfects, evolves and resists therapy in chronic pulmonary disease, highlighting critical challenges for clinicians.
www.emjreviews.com/en-us/amj/re...
#AMJRespiratory #InfectiousDiseases #PulmonaryDisease #NTM
💉 GLP-1 receptor agonists may protect against right heart failure and pulmonary hypertension in people with obesity, showing promising cardiovascular benefits that extend beyond weight loss, new research reveals.
www.emjreviews.com/en-us/amj/re...
#AMJRespiratory #Cardiology #GLP1 #Obesity
🧫 Nasal irrigation could replace sputum testing for infection monitoring in cystic fibrosis. The method accurately detects P. aeruginosa and S. aureus, offering a practical, non-invasive diagnostic tool.
www.emjreviews.com/en-us/amj/re...
#AMJRespiratory #CysticFibrosis
New front-line strategy: Combining osimertinib with chemotherapy in EGFR-mutated advanced NSCLC achieved a median overall survival of 47.5 months versus 37.6 months with osimertinib alone, a 23% reduced risk of death.
www.emjreviews.com/en-us/amj/re...
#AMJRespiratory #LungCancer
🧪 Early data from a Phase II trial found that azelastine nasal spray reduced PCR-confirmed COVID-19 infections, signalling its potential role in respiratory virus prevention alongside vaccines.
www.emjreviews.com/en-us/amj/re...
#AMJRespiratory #InfectiousDiseases @amjreviews.bsky.social
🧪 Hidden culprit in younger CAP cases: Mycoplasma pneumoniae. Study finds it represents 33% of pneumonia in adults under 50 and is linked to delayed recognition and prior antibiotic use, highlighting diagnostic gaps.
www.emjreviews.com/en-us/amj/re...
#AMJRespiratory #InfectiousDiseases #AMJ
🍭 Emerging research suggests that certain food additives could disrupt immune pathways and worsen inflammation in children with asthma, offering new clues into dietary impacts on respiratory health.
www.emjreviews.com/en-us/amj/re...
#AMJRespiratory #Asthma #Allergy #PediatricHealth
🌫️ Indoor wood burning linked to lung risks. A major UK study finds affluent households using wood burners drive PM2.5 emissions, raising concerns over respiratory health and environmental justice.
Full story:
www.emjreviews.com/respiratory/...
#AMJRespiratory #LungHealth #AirPollution
🩺 AI models forecast urgent care needs in NSCLC during systemic therapy. Adding wearable and patient-reported data boosts accuracy, enabling proactive interventions to improve care delivery.
www.emjreviews.com/en-us/amj/re...
#AMJRespiratory #LungCancer #MachineLearning
🧬 New analysis finds biologics directed at type 2 inflammation deliver the clearest benefit in eosinophilic COPD. Dupilumab stood out for reducing flares and boosting lung function outcomes.
www.emjreviews.com/en-us/amj/re...
#AMJRespiratory #COPD #Biologics
🌍 At #WCLC2025, researchers revealed IFITM3 as a key driver of immunotherapy response in SCLC, boosting antigen presentation and T cell activity while emerging as a potential biomarker and target.
www.emjreviews.com/en-us/amj/re...
#AMJRespiratory #LungCancer #Immunotherapy #WCLC
🧬 First-in-human trial of DLL3-targeted therapy SHR-4849 demonstrates a 59.5% ORR and 90.5% disease control rate in relapsed small cell lung cancer, with encouraging safety.
www.emjreviews.com/en-us/amj/re...
#AMJRespiratory #LungCancer
🫁 Children with asthma face increased fracture risk, linked to corticosteroid use. Recent inhaled exposure posed the highest danger, highlighting the need for bone health in pediatric asthma management.
www.emjreviews.com/en-us/amj/re...
#AMJRespiratory #Asthma
🫁💊 GLP1 therapy cuts AHI and weight in OSA...
www.emjreviews.com/en-us/amj/re...
#AMJRespiratory #SleepApnea #OSA #GLP1
🫁 Severe Legionnaires’ disease in ICU patients had more favorable outcomes than past reports suggest. Age and early organ failure scores were key mortality predictors.
www.emjreviews.com/en-us/amj/re...
#InfectiousDiseases #Pulmonology #CriticalCare #AMJRespiratory
🫁💊 Elexacaftor-tezacaftor-ivacaftor linked to a 72% drop in severe liver complications in cystic fibrosis, plus reduced mortality and lung transplant needs, without higher liver failure risk.
www.emjreviews.com/en-us/amj/re...
#AMJRespiratory #CysticFibrosis #LiverDisease
🧠💊 Parkinson’s drug benztropine demonstrates strong host-directed effects against Mycobacterium tuberculosis, reducing lung bacterial load by as much as 70% in preclinical models. Researchers also identified histamine receptor 1 as the key target.
www.emjreviews.com/en-us/amj/re...
#AMJRespiratory
💨 Oxygen delivery choice matters! A new study finds some methods can lower intubation risk in severe pneumonia, though survival rates remain unchanged. Evidence to guide ICU care decisions.
🔗 www.emjreviews.com/en-us/amj/re...
#CriticalCare #Respiratory #Pneumonia #ICU #AMJRespiratory
