Enhanced brain cells clear dementia-related amyloid beta peptides – BioNews Central A single injection of a new cellular immunotherapy prevents and reduces amyloid plaques in mice. ...

A single injection of a new cellular #immunotherapy prevents and reduces #AmyloidPlaques in mice.
#AlzheimersDisease #Dementia

youtube.com/watch?v=cCLl...
Darn. So looking fwd to a
"Razin' Cain" joke, for the 500th time.

#AmyloidPlaques
#SOTU

A neurodegenerative cellular stress response linked to dark microglia and toxic lipid secretion Flury, Aljayousi, et al. pinpoint a novel microglia phenotype in Alzheimer’s disease characterized by a stress-related signaling pathway. Activating this pathway induces microglia to secrete toxic lip...

Dark microglia are typically identified by their low expression of homeostatic microglial markers (e.g., Iba1, CX3CR1, P2RY12) and high expression of CD11b and the phagocytosis marker 4D4, with some expressing TREM2, especially when associated with #amyloidplaques
www.cell.com/neuron/abstr...

Gantenerumab 'shows sign of preventing Alzheimer's dementia' A study has suggested early targeting of amyloid in the brains of people with inherited Alzheimer's can delay symptoms, but not all are convinced.

A study of #Roche's anti-amyloid drug gantenerumab has suggested that early treatment to remove #amyloidplaques from the brain years before symptoms arise may delay the onset of #Alzheimer's #dementia – although some specialists have urged caution.

pharmaphorum.com/news/gantene...

Alzheimer's treatment may lie in the brain’s own immune cells – BioNews Central A study on Alzheimer's patients who received amyloid-beta-targeted immunotherapy may change future treatments by shifting the focus from removing amyloid plaques to using the brain's natural immune defenses. ...

A study on #AlzheimersPatients who received #AmyloidBeta -targeted #immunotherapy may change future treatments by shifting the focus from removing #AmyloidPlaques to using the #brain's natural #ImmuneDefenses.
#AlzheimersDisease #Microglia

Poorly insulated nerve cells promote Alzheimer’s disease in old age Researchers at the MPI-NAT have shown that defective myelin actively promotes disease-related changes in Alzheimer’s disease.

Poorly insulated nerve cells promote Alzheimer’s disease in old age #neuroscience #alzheimer #myelin #amyloidplaques #mousemodel

Study uncovers roles of certain brain cells in Alzheimer's plaque formation A study in Nature Neuroscience found that both neurons and oligodendrocytes contribute to amyloid-β plaque burden in Alzheimer's disease, highlighting new therapeutic targets.

Study uncovers roles of certain brain cells in Alzheimer's plaque formation 🧠🔬🧩 www.news-medical.net/news/2024080... #AlzheimersResearch #Neuroscience #AmyloidPlaques #BrainCells #Oligodendrocytes #Neurons #BACE1Inhibition #CognitiveHealth @natureportfolio.bsky.social

Study finds Plexin-B1 could be key to Alzheimer’s treatment, enhancing glial cell response Researchers discovered that Plexin-B1 plays a crucial role in regulating peri-plaque glial nets in Alzheimer’s disease, potentially opening new avenues for treatment by targeting this protein.

Study finds Plexin-B1 could be key to Alzheimer’s treatment, enhancing glial cell response 🧠🔬🧪 www.news-medical.net/news/2024052... #Alzheimers #PlexinB1 #Neuroscience #Brain #Health #AmyloidPlaques #GlialCells#Neuroinflammation #SynapticFunction #Memory @natureportfolio.bsky.social

Abstract

#clinicaltrials of #antibodies targeting aggregated forms of #βamyloid have shown that reducing #amyloidplaques can mitigate cognitive decline in patients with early-stage AD…
insight.jci.org/articles/vie...

Poorly insulated nerve cells promote Alzheimer’s disease in old age Researchers at the MPI-NAT have shown that defective myelin actively promotes disease-related changes in Alzheimer’s disease.

Scientists around @ConstanzeDepp, @TingSun_MPINAT & @KlausNave have now shown that defective #myelin actively promotes disease-related changes in #Alzheimer’s. Read more about their #research findings here: ⬇ @Nature #nervecell #amyloidplaques #microglia
https://www.mpinat.mpg.de/4463902/pr_2308