#Microglia-derived #nanovesicles is engineered to co-deliver CMA and #macroautophagy inducers across the BBB, synchronously restoring #proteostasis, clearing #βAmyloid, reducing #neuroinflammation, and rescuing cognition in #AlzheimersDisease models.

#STTT: doi.org/10.1038/s413...

Prediction of continuous amyloid positron emission tomography with fluid measures of phosphorylated #tau and #βamyloid 👉 doi.org/10.1038/s443...

By N. Mattsson-Carlgren, L. Karlsson, O. Hansson & colleagues @lund-university.bsky.social

#βamyloid in skull bone marrow drives IL-6–dependent age-associated B cells to infiltrate the #brain, accelerate #amyloid deposition, while #IL6R blockade improves cognition, highlighting #BoneMarrow B cells as potential targets in #AlzheimersDisease.

#STTT: doi.org/10.1038/s413...

Abstract

#clinicaltrials of #antibodies targeting aggregated forms of #βamyloid have shown that reducing #amyloidplaques can mitigate cognitive decline in patients with early-stage AD…
insight.jci.org/articles/vie...