🧬 A new research letter in The FASEB Journal finds that AcrVIA6 doesn’t inhibit Cas13a as once thought. It binds DNA but doesn’t block RNA cleavage, shifting how we think about CRISPR regulation.
🔗 buff.ly/ZFxq6MO
#CRISPR #AntiCRISPR #FASEBJournal #ResearchLetter

Natively expressed AcrIII-1 does not function as an anti-CRISPR protein Nature - Natively expressed AcrIII-1 does not function as an anti-CRISPR protein

Our new paper on archaeal anti-CRISPRs is out in
@Nature (@SpringerNature)! 🔗 rdcu.be/eh1Ma
Using a native virus–host model (SIRV2–S. islandicus), we show that overexpression in foreign hosts can lead to false positives.
🧵(1/n) #CRISPR #archaea #antiCRISPR #virology

Now @DominikNiopek talks about using #optogenetics and the LOV2 domain to control #anticrispr proteins at #KSgenome and introduces my new favorite acroynm of the meeting: CASANOVA.@addgene has multiple optogenetic resources

Addgene: Tissue-restricted Genome Editing in vivo Specifi...

Now we have @JooyoungLee10 from the Sontheimer lab speaking at the #KSgenome #anticrispr workshop, talking about work from her recent RNA paper: https://www.addgene.org/browse/article/28203320/