New findings reveal that while BPA analogues show minimal effects on coagulation or erythrocytes at achievable concentrations, bisphenol PH is a potent antiplatelet agent acting through COX‑1 inhibition, potentially elevating bleeding risk. doi.org/10.1016/j.et...
#bisphenols #antiplatelet
8/ #ESUS = suspected cardioembolic stroke but w/o afib. #Anticoagulation in this patient population has not definitively demonstrated to be superior to #antiplatelet
A recent meta analysis of the available trials showed no superiority:
HIGHLIGHTS FROM AUGUST ISSUE
🗣️Expert Guidance for Severe #Bleeding on #OralAnticoagulation
💊 #Antiplatelet for High Ischaemic and Bleeding Risks Patients After #PCI
Validity of #DIC Based on ICD-10 in a Claims Database
read more: tinyurl.com/2ssjnsv2
#antiplatelet #health #gerontology #primaryhealthcare #pathology #bloodclot
Platelet hyperreactivity and aggregation
are promoted by
gut-liver metabolites, such as
indoxyl sulfate, PAGln, and TMAO,
and reduced by sunlight (near-infrared, vitamin D),
and nighttime endogenous melatonin synthesis.
🚨 Retrospective study: Platelet transfusions don’t prevent ventriculostomy hemorrhage in aSAH—even on DAPT
🔄 Timing didn’t matter
❌ No outcome benefit
🧠 Symptomatic bleeds still rare
📖 doi.org/10.1016/j.jo...
#NeurocriticalCare #Neurosurgery #SAH #Antiplatelet #ICU #NeuroTwitter #MedTwitter
Summary of the guideline recs for #anticoagulant & #antiplatelet therapy in ACS c/w prior recs in @americanheart.bsky.social @accintouch.bsky.social and @escardio.bsky.social guidelines. Thankful to Writing Committee & also a great team who made this summary possible:
www.jacc.org/doi/10.1016/...
Longtime #HMS collaborative partner Dr. Scott Kaatz made the morning fun with a session on perioperative #anticoagulation & #antiplatelet management.
🩸From warfarin tips to DOAC strategies, plus live interaction & prizes – it was a jackpot! 🎰
#SHMConverge25
Genotype-guided #antiplatelet therapy can optimize the balance between ischemic & bleed risk for #ACS patients. The CE marked Genomadix Cube can help! Benefits include:
✅1 hour results
✅No liquid handling
✅No incubations
1. van den Broek et al. JACC.2024;84:1107-1118.
#Cardiology #DAPT
Letter to editor
Pharmacodynamic interaction between ginger and antiplatelet drugs: A case report
www.em-consulte.com/article/1726...
#Herb #drug #Interaction #Antiplatelet #Agent #Clopidogrel #Ginger #AdverseEffects
#Aplagon #APACtherapeutic #thromboinflammatorydiseases #heparinproteoglycanmimetic #antiplatelet #anticoagulant #mastcellderivedheparinproteoglycans #antithrombotic #antiinflammatory #peripheralarterialocclusivedisease #chroniclimbthreateningischemia #PAOD #CLTI
pharmatimes.com/news/aplagon...
When pts have stable #CAD & #AF, do we need both #anticoagulant therapy and #antiplatelet agents? Our collaborative meta-analysis of RCTs shows that monotherapy with anticoagulation ⬇️🩸 without a large increase in ischemic events. @jaccjournals.bsky.social
www.jacc.org/doi/10.1016/...
www.cell.com/trends/pharm...
www.cell.com/trends/pharm...
#CVD #platelet #demographic #population #antiplatelet
23) The authors concluded that #abelacimab tended to provide a greater absolute risk reduction for 🩸 in pts on #antiplatelet therapy than a conventional #DOAC, even beyond the difference seen in #AZALEA for pts treated overall. The #FXI hypothesis continues to be strengthened!
The latest @BMJ_Qual_Saf blog on clinical improving #antiplatelet therapy uptake:
blogs.bmj.com/qualitysafety/…
#cardiovascularhealth #healthinequity #medication #QI
