No. 5 #BJGPTop10 Antidepressants and postural hypotension: A risk to consider when prescribing for over 60s doi.org/10.3399/BJGP...
#MentalHealth #Antidepressants #PatientSafety #HealthcareResearch #OlderAdults #AdverseEffects #FallsPrevention #PrimaryCare #BJGP #research

Toxicities Associated with Sacituzumab Govitecan

Data from multiple sources provide insights into the safety profile of #Sacituzumab #Govitecan (SG), identifying common hematologic toxicities and unexpected #AdverseEffects, underscoring the need for critical clinical monitoring & management.

Read: doi.org/10.1007/s115...

Childhood trauma and subclinical PTSD symptoms predict adverse effects and worse outcomes across two mindfulness-based programs for active depression Within mindfulness-based programs (MBPs), mixed results have been found for the role of childhood trauma as a moderator of depression outcomes. Furthermore, childhood trauma and PTSD symptoms have bee...

This is why trauma-sensitive mindfulness training should be required for teacher credentialling.

journals.plos.org/plosone/arti...

#mindfulness #mentalhealth #depression #depressionmanagement #adverseeffects #MBCT #traumasensitivemindfulness #trauma #traumarecovery

Electroconvulsive therapy may have more adverse effects than thought Study calls for depression treatment to be suspended for more research after reports of heart problems and emotional blunting Electroconvulsive therapy could be causing a wider range of adverse effects...

Electroconvulsive therapy may have more adverse effects than thought #Science #HealthandMedicine #MentalHealth #ElectroconvulsiveTherapy #AdverseEffects

Everyone always asks me, what were your very first signs that something was wrong when I took Cipro?

To watch 👇🏼
youtu.be/XCLrC19w9QE

#floxed #Ciprofloxacin #Cipro #podcast #interview #warning #awareness #Fluoroquinolones #fqtoxicity #symptoms #AdverseEffects #howitstarted

Adverse Events Following Short-Course Systemic Corticosteroids Among Children and Adolescents: A Systematic Review and Meta-Analysis - PubMed In this systematic review and meta-analysis of randomized trials, there was moderate certainty evidence that corticosteroids were associated with an increased risk of hyperglycemia and sleep problems and low certainty evidence that corticosteroids were associated with increased risk of gastrointesti …

Just published #MetaAnalysis of #AdverseEffects of short-course #steroids in #children and #adolescents in many diseases can provide high certainty evidence for their use in #RareDisease. Generally applicable approach for harms of common drugs in rare diseases.

pubmed.ncbi.nlm.nih.gov/41026484/

Frontiers | “I was trying to save the world”: delusion-like ideation and associated impacts reported by Western practitioners of Buddhist meditation Delusional ideation is characteristic of psychopathology (e.g., psychosis, bipolar disorder) and is also found among the general population. Contemporary cas...

I'd be curious to see a scan of my brain's activity anytime I see research from Willoughby Britton, because it's always insightful, and perhaps literally enlightening.

www.frontiersin.org/journals/psy...

#mindfulness #meditation #adverseeffects #buddhism #mentalhealth #wellbeing

AMP just published!
”Obstruction of Transplanted Kidney from Urinary Catheter Misplacement”

Full paper here:
www.actamedicaportuguesa.com/revista/inde...

#incidentalfindings #kidneytransplantation #urinarycatheterization #adverseeffects #actamedicaportuguesa

Frontiers | Detached self-observation as a developmental catalyst: theoretical insights from dynamical systems thinking, cultural mediation, and contemplative practice Detached self-observation, a central dimension of mindfulness meditation, has emerged as a key metacognitive and emotional-regulatory capacity across psychol...

Really interesting article, in particular about some potential risks with detachment.

www.frontiersin.org/journals/psy...

#mindfulness #meditation #adverseeffects #mentalhealth #detachment #culturalintelligence #depersonalization

Eight ADCs Associated With Significant Risk for Interstitial Lung Disease - Oncology Nurse Advisor Researchers analyzed data from the FAERS to determine the prevalence of interstitial lung disease among patients with cancer receiving antibody-drug conjugates

Ten of the 15 antibody-drug conjugates were associated with ILD events.

https://bit.ly/3Ki8CSr

#adverseeffects

ROS, central to the cytotoxic effects of many #anticanceragents, disrupts redox homeostasis, contributing to inflammation, cellular dysfunction & long-term #adverseeffects like #cardiotoxicity, #neuropathy & #fibrosis. Chronic oxidative stress plays 🔑 role in modulating #drugresistance pathways,

Overall, 55.4% of patients with LGS achieved ≥50% seizure reduction with neuromodulation therapies.
doi.org/10.1111/epi....

#epilepsy #Epilepsia #ILAE #adverseeffects #DEE #drugresistant #neurostimulation #qualityoflife #treatment

Researchers Gain New Insight Into Long-Term Effects of Chemotherapy - Oncology Nurse Advisor Most chemotherapy recipients had mutation burdens that were higher than expected for their age.

Chemotherapy can increase mutation burden and change the cell population structure of normal blood, which contributes to long-term #adverseEffects such as second malignancies and infertility, according to researchers. From @natureportfolio.nature.com & @cancertherapyadv.bsky.social.

bit.ly/4nPlP4l

ICYMI: How well do you know your dopamine antagonists?

TI Therapeutics Letter: ti.ubc.ca/letter139
Patient experience videos:

Pts explain why it's important for prescribers, carers, pharmacists, pts, to recognize early occurrence of #AdverseEffects

#medsafety #ptsafety #deprescribing

Fecal microbiota transplants: Promising treatment or potential health risk? – BioNews Central New research cautions against widespread use of fecal microbiota transplants because of the potential for long-lasting, unintended health consequences for recipients. ...

New research cautions against widespread use of #FecalMicrobiotaTransplants because of the potential for long-lasting, unintended health consequences for recipients.
#GutMicrobiome #FecalTransplants #OffTargetEffects #AdverseEffects

This study provides a comprehensive profile of #SacituzumabGovitecan (SG) toxicity based on #clinicaltrials, the #FAERS database, and the DDInter database, identifying several new #adverseeffects (AEs) and drug–drug interactions associated with SG. #medsky

Read more: buff.ly/o8vzuAZ

There Is No Such Thing as Green Capitalism | Los Angeles Review of Books David Shipko explores climate denialism in speculative literature and culture.

'No scientific evidence verifies the would-be geoengineer’s desire for a planetary climate system susceptible to consequence-free fine-tuning. Instead, researchers have identified a wide range of potential negative consequences'
lareviewofbooks.org/article/ther...

#geoengineering #AdverseEffects

‘Het vee eet deze maïs, je wil niet dat het glas bevat’, zegt de boer die in Dongen de scherven van verbrande zonnepanelen uit het weiland raapt Zonnepanelen in de wei: Na een grote brand bij een leerlooierij in het Brabantse Dongen liggen naburige akkers en weilanden bezaaid met resten van zonnepanelen. Die moeten worden opgeruimd. En de bran...

"The cattle eat this corn, you don’t want it to contain glass"
www.nrc.nl/nieuws/2025/... (Dutch)

'The sea of ​​fire ... sent the remains of solar panels into the air, which fell as far as twenty kilometres south, in a strip almost a hundred metres wide'

#SolarPanels #technology #AdverseEffects

Research Article

Effect of Age on Rheumatic Immune-Related Adverse Events: Experience From the Canadian Research Group of Rheumatology in Immuno-Oncology (CanRIO)

📖 www.jrheum.org/cgi/content/...

#adverseeffects #autoimmunediseases #rheumaticdiseases

AMP just published!
"Renal Safety Issues of Intravenous Iodinated Contrast Media Are Questionable"

Full paper here:
www.actamedicaportuguesa.com/revista/inde...

#acutekidneyinjury #contrastmedia #adverseeffects #intravenouscontrast #actamedicaportuguesa

Pharmacodynamic interaction between ginger and antiplatelet drugs: A case report Pharmacodynamic interaction between ginger and antiplatelet drugs: A case report

Letter to editor

Pharmacodynamic interaction between ginger and antiplatelet drugs: A case report

www.em-consulte.com/article/1726...

#Herb #drug #Interaction #Antiplatelet #Agent #Clopidogrel #Ginger #AdverseEffects

Research on cannabis adverse effects often treats it as a single entity, ignoring differences in pharmacodynamics & pharmacokinetics of its various constituents—some of which have opposing effects. 🌱🧬⚖️”#CannabisResearch #Pharmacology #Cannabinoids #CannabisScience #AdverseEffects #BalancedDiscussion

Dexamethasone benefits in multiple myeloma ‘fade into oblivion’ after a couple months Decreasing the amount of dexamethasone that individuals with newly diagnosed multiple myeloma received did not affect survival, according to a secondary analysis of completed clinical trials.Nearly 70...

#MedSky🧪 #Drugs #Adverseeffects Reducing #dexamethasone doses in #multiplemyeloma doesn't affect survival, but toxicity remains a concern.

www.healio.com/news/hematol...

Semaglutide improves heart health and reduces weight in obese patients, but with side effects Semaglutide significantly reduces cardiovascular events and adverse effects in overweight and obese patients. The study highlights semaglutide's superiority over other GLP-1 agonists for cardiovascula...

Semaglutide improves heart health and reduces weight in obese patients, but with side effects 🫀📊💊 www.news-medical.net/news/2024101... #Semaglutide #Cardiovascular #Health #Obesity #WeightLoss #Diabetes #GLP1Agonists #AdverseEffects

#OnlineFirst w/#PMT #JPharmTechnol - 2 case reports on #drugsafety: Casella & Galli explore appendicitis in patients on GLP-1 RAs: ttps://journals.sagepub.com/doi/abs/10.1177/87551225231216638
DeBono et al report #adverseeffects w/nivolumab in RCC: journals.sagepub.com/doi/abs/10.1... #pharmacy

I like learning from experts on this app...please name Rx medications that cause neuropsychiatric adverse effects (even without drug interactions, and even in younger people). I'll start: prednisone, efavirenz, levetiracetam... #adverseeffects #medication #HIV