Carbamazepine was associated with increased interictal activity, while valproate–lamotrigine was associated with reduced activity in the IGEs.
doi.org/10.1002/epi....
#epilepsy #ILAE #epilepsia #ambulatory #EEG #antiseizuremedication #IGE #interictalepileptiformdischarges #vEEG
URE patients had a median of six failed treatment strategies, including surgery or neurostimulation.
doi.org/10.1002/epi4...
#epilepsy #ILAE #epilepsiaopen #antiseizuremedication #drugresistantepilepsy #neurostimulation #resectivebrainsurgery #ultrarefractoryepilepsy
PIPs for antiseizure medications have mainly focused on focal seizures so far. Limited compliance and incomplete trials represent ongoing challenges in pediatric antiseizure drug development.
doi.org/10.1111/epi....
#epilepsy #ILAE #epilepsia #antiseizuremedication #drugdevelopment #seizure
This is the first placebo-controlled cenobamate efficacy study to use the globally approved cenobamate titration schedule.
doi.org/10.1111/epi....
#epilepsy #ILAE #epilepsia #antiseizuremedication #efficacy #refractory #titration #cenobamate
This post hoc analysis evaluates perampanel as first adjunctive therapy for epilepsy across different clinical and regional settings.
doi.org/10.1002/epi4...
#epilepsy #ILAE #epilepsiaopen #antiseizuremedication #firstaddontherapy #focalepilepsy #focalonsetseizures #tonicclonicseizures #perampanel
We compared the early adjuvant treatment outcomes of IV lacosamide and levetiracetam for status epilepticus after benzodiazepine use.
doi.org/10.1002/epi4...
#epilepsy #ILAE #epilepsiaopen #antiseizuremedication #diagnosisprocedurecombination #overlapweighting #propensityscore #seizure
DRPLA patients with epilepsy have earlier onset and longer CAG repeats than those without epilepsy.
onlinelibrary.wiley.com/doi/10.1111/...
#epilepsy #ILAE #epilepsia #antiseizuremedication #dentatorubralpallidoluysianatrophy #progressivemyoclonicepilepsy #trinucleotiderepeatdisorders
We evaluated the efficacy and safety of adjunctive cenobamate (100, 200, and 400 mg/day) in Asian patients with uncontrolled focal seizures.
doi.org/10.1111/epi....
#epilepsy #ILAE #epilepsia #antiseizuremedication #focalepilepsy #phase3 #refractory
AI models integrating magnetic resonance imaging, clinical, and antiseizure medication (ASM) data predicted seizure freedom in newly diagnosed epilepsy.
doi.org/10.1111/epi....
#epilepsy #ILAE #epilepsia #antiseizuremedication #artificialintelligence #brainMRI #epilepsyimaging #machinelearning #AI
We present the largest series reporting on the off-label use of Cenobamate (CNB) in 16 adults with drug-resistant idiopathic generalized epilepsy, including 12 with JME.
onlinelibrary.wiley.com/doi/10.1002/...
#epilepsy #ilae #epilepsiaopen #antiseizuremedication #Cenobamate #healthcareutilization
A cost-effectiveness analysis of initial BRV versus LEV therapy was conducted across the US, Australia, and Japan.
doi.org/10.1002/epi4...
#epilepsy #ILAE #epilepsiaopen #antiseizuremedication #healthcareeconomics #levetiracetam #riskstratification
A two-year terminal seizure freedom was more commonly achieved in patients with GTCA and GGE-NOS, compared to those with JME.
doi.org/10.1002/epi4...
#epilepsy #ILAE #epilepsiaopen #adultonset #antiseizuremedication #geneticgeneralizedepilepsy #seizureoutcome #terminalremission
BRV as an add-on therapy significantly reduces seizure frequency in patients with focal onset seizures.
doi.org/10.1002/epi4...
#epilepsy #ILAE #epilepsiaopen #antiseizuremedication #brivaracetam #combination #drugtherapy #focalonsetseizures #seizures
We report the impact of climatic variables on hyponatremia-related hospitalizations in a well-phenotyped cohort of people with focal #epilepsy exposed to #carbamazepine or its derivatives.
doi.org/10.1111/epi....
#epilepsia #ILAE #antiseizuremedication #climatechange #focalepilepsy #hyponatremia
CBD treatment resulted in a comparable reduction in focal seizure frequency of 51%–87% in the TSC group and 46–75% in the non-TSC group.
doi.org/10.1111/epi....
#epilepsy #ILAE #epilepsia #antiseizuremedication #cannabidiol #corticaldysplasia #focalepilepsies #focalseizures
Clobazam, stiripentol, and fenfluramine reduce seizures effectively; valproic acid has no significant effect.
doi.org/10.1002/epi4...
#epilepsy #epilepsiaopen #ILAE #antiseizuremedication #DEE #Dravetsyndrome #Drosophilamelanogaster
We used prescription data to evaluate the retention of newer antiseizure medications (ASMs) in routine epilepsy care across Sweden, focusing on early use.
doi.org/10.1111/epi....
#epilepsy #Epilepsia #ILAE #antiepilepticdrug #antiseizuremedication #discontinuation #lacosamide #seizure
We used novel TMS techniques to investigate how two antiseizure medications, carbamazepine and lacosamide, affect axonal excitability in cortical neurons.
doi.org/10.1111/epi....
#epilepsy #epilepsia #ILAE #antiseizuremedication #axonalmembrane #cortex #ionchannel #transcranialmagneticstimulation
The efficacy of perampanel as a second-line therapy to midazolam for refractory SE was evaluated in soman-exposed rats.
doi.org/10.1002/epi4...
#epilepsy #ilae #epilepsiaopen #AMPA #antiseizuremedication #cholinergic #organophosphorusnerveagent #pharmacoresistance
Clinicians should rule out contributing etiologies and consider CNB dose reduction if excessive weight loss occurs.
doi.org/10.1111/epi....
#epilepsy #epilepsia #ILAE #antiseizuremedication #weightchange #Cenobamate
Key point: The first antiseizure medication was retained in use in 57.9% of the patients until the end of the follow-up.
doi.org/10.1002/epi4...
#epilepsy #ILAE #epilepsiaopen #antiseizuremedication #retention #braintumor #seizures
Key point: We examined differences in ESM initiation patterns among Traditional Medicare beneficiaries after AIS discharge
doi.org/10.1111/epi....
#epilepsy #Ilae #epilepsia #acuteischemicstroke #antiseizuremedication #initiationpatterns #olderadults
Key point: ACT-709478 is a potent blocker of all three T-type Ca2+ channels without off-target activities.
onlinelibrary.wiley.com/doi/10.1111/...
#epilepsy #Ilae #epilepsia #absenceseizures #antiseizuremedication #convulsiveseizures #GAERS #TtypeCa2+channelblocker #WAG/Rij
Key point: Seizure freedom was achieved in 84% of patients, but 51% had severe intellectual impairments.
onlinelibrary.wiley.com/doi/full/10....
#epilepsy #ILAE #epilepsia #Antiseizuremedication #ASM #Hemispherotomy #MRIabnormalities #Polymicrogyria #Seizurefreedom
Comparison of lacosamide, levetiracetam, and valproate as second-line therapy in adult status epilepticus: Analysis of a large cohort
doi.org/10.1111/epi....
#epilepsy #ilae #epilepsia #antiseizuremedication #cohortstudy #comparativestudy #lacosamide #statusepilepticus
Key point: wEEG is useful for frequent 12–24-h home-based monitoring in adult patients with typical absence seizures.
doi.org/10.1111/epi....
#epilepsy #ilae #epilepsia #absenceseizures #antiseizuremedication #idiopathicgeneralizedepilepsy #personalizedmedicine #wearableelectronicdevices
Key point: We hypothesized that the time course of the BASED score after ES remission is associated with ES relapse.
doi.org/10.1111/epi....
#epilepsy #ilae #antiseizuremedication #electroencephalography #hypsarrhythmia #interraterreliability #Westsyndrome
Key point: Observed concentration ranges for the included anti-seizure medications showed good overall concordance with established reference ranges from Danish laboratories except for levetiracetam.
doi.org/10.1111/epi....
#epilepsy #ILAE #antiseizuremedication #therapeuticdrugmonitoring
Key point: Patients included in this EAP had a median history of 22 years of epilepsy, a median of 9 prior failed ASMs, and 41.9% had epilepsy surgery.
doi.org/10.1002/epi4...
#epilepsy #ilae #epilepsiaopen #antiseizuremedication #cenobamate #responderrate #seizurefreedom
Key point: A total of 375 patients enrolled in this Dravet syndrome (DS) open-label extension (OLE) study; fenfluramine (FFA) median treatment duration was 824 days (n = 368).
doi.org/10.1111/epi....
#epilepsy #ilae #antiseizuremedication #seizure
