Persistence and spread of fluconazole-resistant Candida parapsilosis clinical isolates associated with increased ERG11 copies in Qatar Candida parapsilosis is one of the most common species associated with candidemia infections globally. Recently, the emergence of fluconazole-resistant (FLU-R) C. parapsilosis has become a significant...

Excellent work from Zhu and Yue, plus good team work from Drs, scientists in Qatar, Canada and Singapore. #Candida #azoles #CNV
www.microbiologyresearch.org/content/jour...

How Antifungal Medicines Work in Managing Fungal Diseases? Antifungal drugs fight infections caused by fungi. These infections show up in all sorts of ways sometimes as a mild rash, sometimes as something much more serious, affecting your lungs, blood oreven your organs. The drug you need depends on the kind of fungus and where it’s causing trouble. Some antifungals punch holes in the fungus’s cell membrane; others mess with how it grows or reproduces.Azoles are one of the main types of antifungal drugs. You’ve probably heard of names like fluconazole,

#Azoles are one of the main types of #antifungal drugs. You’ve probably heard of names like #fluconazole, #itraconazole #Zisavel 100mg Capsule, #ketoconazole #orvoriconazole. They work by stopping #fungi from making #ergosterol.

mrmedpharmacy.wixsite.com/blog/post/ho...

Synthesis and Biological Evaluation of Itraconazole Derivatives: Design in an Old Scaffold | Inorganic Chemistry pubs.acs.org/doi/10.1021/... @GasserGroup and co-workers @InorgChem #ferrocene #itraconazole #antimicrobial #ERG11 #azoles

'The unregulated use of azoles by farmers and gardeners to combat fungi is leading to increasing numbers of resistant fungi and life-threatening fungal infections.'
bsky.app/profile/crye... (Dutch, paywall)

#neoliberalism #IndustrialFarming #pesticides #azoles #fungi #mold

Uncover the selectivity!✨ Zanatta & co-workers are presenting a direct N-alkylation/arylation methodology for #imidazoles, #pyrazoles, and #triazoles. Their work, featuring brominated enones, creates N-alkylated #azoles with furans or dihydrofurans.

👉 buff.ly/wzbCzlm

One Health: EU agencies unite to tackle azole fungicide resistance in Aspergillus fungi For the first time, the five EU health and environment agencies – EFSA, ECDC, ECHA, EEA and EMA[1]– supported by the JRC, reviewed how the use of azole substances outside human medicine affects public...

The #OneHealth Agencies and #EFSA: The extensive use of #azoles, particularly in some agricultural and horticultural practices, can increase the risk of #Aspergillus fungi developing resistance to essential treatments, a serious risk to #PublicHealth www.efsa.europa.eu/en/news/one-...
#HealthCare

Agencias de la UE se unen para abordar la resistencia a los fungicidas azólicos en hongos Aspergillus El uso extensivo de fungicidas azólicos (azoles), en particular en algunas prácticas agrícolas y hortícolas, puede aumentar el riesgo de que los hongos Aspergillus desarrollen resistencia a ...

Agencias de la UE se unen para abordar la resistencia a los fungicidas #azólicos en hongos #Aspergillus #azoles @ema.europa.eu

Impact of the use of azole fungicides, other than as human medicines, on the development of azole‐resistant Aspergillus spp. The use of azoles in the European Union and European Economic Area (EU/EEA) other than as human medicines has raised concerns about emergence and spread of azole‐resistant Aspergillus species. EU agen...

Find the five agencies' recommendations in:
➡️ the full report: bit.ly/3X35QnR
➡️ the plain language summary: bit.ly/4aH0Z1e
➡️ our press release: bit.ly/3CH77ts

#IDsky #MedSky #EpiSky
#Azoles #OneHealth #PublicHealth

The report highlights that the broad use outside human medicine, contributes to the risk of Aspergillus becoming azole-resistant.

Exposure to #azoles with ex. agricultural & horticultural waste & freshly cut wood, can increase the risk of infection with azole-resistant Aspergillus spp.

#OneHealth

Impact of the use of azole fungicides, other than as human medicines, on the development of azole‐resistant Aspergillus spp. The use of azoles in the European Union and European Economic Area (EU/EEA) other than as human medicines has raised concerns about emergence and spread of azole‐resistant Aspergillus species. EU agen...

#Azoles are used in plant protection products (#pesticides) to control fungal diseases in agriculture & horticulture; veterinary medicines to treat fungal infections in animals; biocides in wood preservatives, as industrial chemicals; in cosmetics.

Report: www.efsa.europa.eu/en/efsajourn...

Azole medicines are essential for treating #aspergillosis, a serious infection caused by Aspergillus fungi. However, these fungi are increasingly becoming resistant to azole therapies, making treatment less effective.

Watch the video by @efsa.europa.eu
#Azoles #OneHealth

One Health: EU agencies unite to tackle azole fungicide resistance in Aspergillus fungi The extensive use of azole fungicides (azoles), particularly in some agricultural and horticultural practices, can increase the risk of Aspergillus fungi developing resistance to essential antifungal ...

#JustPublished!

#OneHealth: EU agencies unite to tackle azole fungicide resistance in Aspergillus fungi.

Joint report by: @ecdc.europa.eu, @efsa.europa.eu, @ema.europa.eu, @euchemicalsagency.bsky.social, #EEA and @ec.europa.eu's Joint Research Centre

Read full here: bit.ly/3CH77ts
#Azoles

microscopic photo of elongated microbes with long flagella

Discovery of enzyme pathway may lead to #leishmaniasis treatments phys.org/news/2024-12...

" #Leishmania have biochemical similarities to #fungi... But scientists were unable to effectively use #antifungals... those #azoles don't work unless they inhibit the new pathway"

#Protists #Parasites

Four #azoles’ profile in the control of #Zymoseptoria and #wheat #rusts across Europe. Clear pattern of decreasing #CYP51 mutation frequencies from west to east. More robust control provided by azoles mixtures across all sites and sensitivities

sciencedirect.com/science/articl…