Zahradník: Chceme být vždy krok před virem „Pokud viru vezmeme ‚nejlepší mutace‘, můžeme ho oslabit,“ říká biochemik Jiří Zahradník, který vede virologickou laboratoř v BIOCEVu. Zkušenosti z prestižního Weizmannova institutu v Izraeli přetavil...

🦠Zastavit další pandemii dřív, než vůbec začne. I to je cíl výzkumu Jiřího Zahradníka @1.lf.unikarlova.cuni.cz @unikarlova.cuni.cz #BIOCEV.
📌 www.ukforum.cz/rubriky/veda...

#research #medchem #neurodegeneration

Investigating NFE2L1 activators for targeted protein aggregate clearance: a follow-up study
(Smahelova, Saskova) – RSC Med. Chem.: doi.org/10.1039/D5MD...

@iocbprague.bsky.social @czechacademy.bsky.social @sciencecharles.bsky.social #biocev

#research #virology #hepB

UBE2O, a host ubiquitin-conjugating enzyme, is a key regulator of hepatitis B virus maturation and egress
(Lubyová, Tikalová, Janovec, Krulová, Kropáček, Hirsch, Weber) – #jbiolchem: doi.org/10.1016/j.jb...

@iocbprague.bsky.social #biocev @czechacademy.bsky.social

#research #ferroptosis

Targeting NFE2L1 signalling with small molecules to protect against Ferroptosis (Svobodová, Sedláček, Šmahelová, Majer, Machara, Grantz Šašková) – BMCL.: doi.org/10.1016/j.bm...

@iocbprague.bsky.social @sciencecharles.bsky.social @charlesuni.cuni.cz #BIOCEV

SPIDocs at work! Lectures and hands-on sessions at the Structural MS Workshop at Biocev.

#Biocev
@peterslab1.bsky.social

Day 1 at the Structural MS Workshop in Biocev!
Straight into the lab! Hands-on HDX-MS, cross-linking, and native top-down MS.
🧪 ⚡ ❤️
Thanks to @spidocs.bsky.social, #OPAJK #Photomachines, @brukercorporation.bsky.social @ciisbinstructcz.bsky.social for the support!
#Biocev @mbuavcr.bsky.social

Registration is open for the Instruct-ERIC Training course on integrative mass spectrometry and AI for protein structural characterization, hosted by @cienciasulisboa.bsky.social!

More below!

instruct-eric.org/events/instr... @astbury-bsl.bsky.social @hche-uhh.bsky.social #UEF #BIOCEV #MSVision

#research #cancertherapy #proteostasis

Impact of proteostasis workload on sensitivity to proteasome inhibitors in multiple myeloma (Sedlacek) – ClinExpMed: link.springer.com/article/10.1...

#BIOCEV @iocbprague.bsky.social @czechacademy.bsky.social @sciencecharles.bsky.social

Activation of the 26S Proteasome to Reduce Proteotoxic Stress and Improve the Efficacy of PROTACs The 26S proteasome degrades the majority of cellular proteins and affects all aspects of cellular life. Therefore, the 26S proteasome abundance, proper assembly, and activity in different life contexts need to be precisely controlled. Impaired proteasome activity is considered a causative factor in several serious disorders. Recent advances in proteasome biology have revealed that the proteasome can be activated by different factors or small molecules. Thus, activated ubiquitin-dependent proteasome degradation has effects such as extending the lifespan in different models, preventing the accumulation of protein aggregates, and reducing their negative impact on cells. Increased 26S proteasome-mediated degradation reduces proteotoxic stress and can potentially improve the efficacy of engineered degraders, such as PROTACs, particularly in situations characterized by proteasome malfunction. Here, emerging ideas and recent insights into the pharmacological activation of the proteasome at the transcriptional and posttranslational levels are summarized.

#review

Activation of the 26S Proteasome to Reduce Proteotoxic Stress and Improve the Efficacy of PROTACs (Sedlacek) - ACS Pharmacology & Translational Science
ACSBioMed: pubs.acs.org/doi/10.1021/...

#BIOCEV @iocbprague.bsky.social

Thrilled to see the progress on #Wolbachia! It’s been a pleasure to join you, @ewachrostek.bsky.social. Big thanks to @eurobioimaging.bsky.social for the funding, and to the amazing team at BIOCEV for their hospitality and support. 🙌🔬 #eurobioimaging #ERC #BIOCEV #Research #Science