#BrainAgeing

🧠💤 New research in Lancet eBioMedicine finds that poor sleep can make your brain age nearly 1 year faster 🕒 Link to full study in the comments #SleepHealth #BrainAgeing #Science #HealthNews

Spatial transcriptomic clocks reveal cell proximity effects in brain ageing | Nature Old age is associated with a decline in cognitive function and an increase in neurodegenerative disease risk1. Brain ageing is complex and is accompanied by many cellular changes2. Furthermore, the influence that aged cells have on neighbouring cells and how this contributes to tissue decline is unknown. More generally, the tools to systematically address this question in ageing tissues have not yet been developed. Here we generate a spatially resolved single-cell transcriptomics brain atlas of 4.2 million cells from 20 distinct ages across the adult lifespan and across two rejuvenating interventions—exercise and partial reprogramming. We build spatial ageing clocks, machine learning models trained on this spatial transcriptomics atlas, to identify spatial and cell-type-specific transcriptomic fingerprints of ageing, rejuvenation and disease, including for rare cell types. Using spatial ageing clocks and deep learning, we find that T cells, which increasingly infiltrate the brain with

Unveil brain ageing! Spatial transcriptomics shows cell proximity effects—reveal key patterns in neurons. Game-changing tool! 🧠 #BrainAgeing PMID:39695234, Nature 2025, @Nature https://doi.org/10.1038/s41586-024-08334-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Bath researchers awarded Wellcome grant for psychotic disorder study - PharmaTimes New funding to investigate cognitive decline and brain ageing

#healthcare #mentalhealth #brainhealth #psychoticdisorder #cognitivedecline #brainageing #prematurebrainageing #psychoticdisorders #cognitiveimpairment #UnlockingCognitiveHealthinPsychoticDisorders #livedexperienceofpsychosis #psychosis #schizophrenia
pharmatimes.com/news/bath-re...

Hi Bluesky! Just made the switch from the other place 😊 I'll be posting about my research interests: #neuroscience #lipid #omega3 #preterm #TBI #mood #brainageing and #neurodegeneration, a little pro EU politics and Covid. Meanwhile, here's my 🐕 🐶