Photo of a wooden cabinet and shelves laden with books and clutter next to a brick wall that shows a planter filled with magazines and a peek at a wooden mantel and fireplace screen.

Sigh. I bet you'll find my flashlight faster than I did. (It took me 3 months. I just noticed where it was this morning.)

#CognitiveImpairment

New episode on #mindfulness for #cognitiveimpairment and #dementia in older adults -- youtu.be/AMKqyYfKOtM

a man in a suit and tie is sleeping in a chair with his eyes closed ALT: a man in a suit and tie is sleeping in a chair with his eyes closed

Concerns about Donald J. Trump’s cognitive decline stems from repeated verbal slips, tangents, & memory lapses in speeches & behavioral patterns. Supporters dismiss these as style, while commonsense argues they indicate diminished focus and coherence. #dementialean #cognitiveimpairment

Define #excursion and then define #incursion #trump #cognitiveimpairment

TDP-43 pathology triggers #neuroinflammation and #CognitiveImpairment by inducing microglial necroptosis, by S. Guo, C. Fu, Y. Yin, W. Cheng & colleagues at Xinhua Hospital, Shanghai

🗞️ doi.org/10.1038/s44321-026-00394-9

Egocentric Spatial Memory Deficit in Amnestic Mild Cognitive Impairment Revealed Through Virtual Reality: Cross-Sectional Study Background: Spatial navigation relies on egocentric and allocentric frames of reference, with the latter critically impaired in Alzheimer disease (AD) due to hippocampal involvement. Recent evidence suggests that egocentric representations may coexist within medial temporal lobe regions; however, their relative impairment in the early stages of AD remains unclear. Virtual reality offers a promising approach to bridge this gap by assessing spatial navigation abilities and providing sensitive digital biomarkers for AD. Objective: This study investigates spatial memory performance in individuals with amnestic mild cognitive impairment (aMCI) using a virtual reality object-location memory task that manipulated available cues during recall. An environmental boundary probed hippocampal-dependent allocentric processing, while a discrete landmark probed striatal-dependent egocentric strategies. Methods: Eighty participants (40 individuals with aMCI and 40 healthy controls [HC]) encoded object locations in a virtual arena and recalled them using either landmark or boundary cues. Results: Regardless of the spatial frame of reference, patients with aMCI demonstrated significantly poorer overall spatial memory than the HC group. Surprisingly, virtual egocentric error emerged as a predictor of aMCI diagnosis. No differences were observed in frame-switching, object-location binding, or across recall trials. Analysis of virtual encoding paths revealed that patients with aMCI exhibited centrifugal navigation away from the discrete landmark and toward the boundary of the arena. During recall, patients with aMCI demonstrated less effective usage of boundary and landmark cues than HC, as revealed by the distribution of response coordinates. Conclusions: These findings indicate that, in addition to well-documented allocentric deficits, egocentric spatial memory impairments provide a complementary and potentially sensitive marker within the AD continuum. This dual impairment of spatial cognition systems may enhance our understanding of navigational difficulties in aMCI and offers insight into the nature of spatial representations in aging.

New in JMIR Aging: Egocentric Spatial Memory Deficit in Amnestic Mild Cognitive Impairment Revealed Through Virtual Reality: Cross-Sectional Study #Alzheimer #CognitiveImpairment #VirtualReality #SpatialMemory #Neuroscience

Hu et al. show that sevoflurane postconditioning alleviates cognitive impairment after hemorrhagic shock and resuscitation by activating the SIRT1/HIF-1α/NLRP3 pathway. doi.org/10.4103/mgr.... #AnestheticGas #Sevoflurane #CognitiveImpairment #Neuroprotection #MedicalResearch #MedSky #neuroskyence

Antibiotic tolerance and safety in infective endocarditis: A focus on older patients Infective endocarditis (IE) is a rare but severe disease with high morbidity and mortality, increasingly affecting older adults. Data on antibiotic to…

[Publication] The article "Antibiotic tolerance and safety in infective endocarditis: A focus on older patients" is now available.

www.sciencedirect.com/science/arti...

#IDsky #InfectiveEndocarditis #OlderAdults #AdverseDrugEvents #CognitiveImpairment #MultidisciplinaryCare

Sevoflurane #postconditioning alleviates cognitive impairment after hemorrhagic shock by activating the SIRT1/HIF-1α/NLRP3 pathway. doi.org/10.4103/mgr.... #Sevoflurane #CognitiveImpairment #HemorrhagicShock #Neuroprotection #SIRT1 #HIF1α #NLRP3 #MedicalResearch #Anesthesia #MedSky #neuroskyence

Relationship between retinal neurodysfunction and cognitive impairment in type 2 diabetes: results of the RECOGNISED cross-sectional study - Diabetologia Aims/hypothesis There are no robust, reliable and easy to administer tests to screen for mild cognitive impairment (MCI) in people living with diabetes. Since the retina is ontogenically brain-derived...

Microperimetry and/or RETeval to assess retinal neurodysfunction combined with simple clinical variables as a new strategy to identify #diabetes with mild #CognitiveImpairment. #Neuroscience #CognitiveHealth #BrainAwareness #retina #EyeHealth link.springer.com/article/10.1... 🔓

Cognitive impairment is associated with altered blood cell profiles in aggressive lymphoma - Supportive Care in Cancer Purpose Cognitive and psychological symptoms in neuropsychiatric disorders have been linked to blood cell parameters, including neutrophil-to-lymphocyte ratios (NLRs), systemic immune-inflammation ind...

🚨New paper🚨 We found #CognitiveImpairment was associated with blood cell parameters in individuals with aggressive lymphoma, indicating distinct biological patterns of dysfunction before, during, and after chemotherapy.
#HaemOnc #SurvOnc #SuppOnc #CRCI
link.springer.com/article/10.1...

Help DPUK's #LACI-Cog study? It's testing 2 treatments for #vascular #cognitiveimpairment & #dementia in people with memory problems caused by damaged blood vessels in the #brain. Access the survey at #POPPED, the PPIE site zurl.co/17YET. Anyone can complete it.

Autonomous AI can spot cognitive decline in medical notes An AI that screens for early cognitive impairment by sifting through routine clinical documents has shown its value in a real-world evaluation.

Researchers in the #US have developed an #agenticAI that can screen for people in the early stages of #cognitiveimpairment by sifting through routine clinical documents.

pharmaphorum.com/news/autonom...

An Ultra-Brief Informant Questionnaire for Case Finding of Cognitive Impairment Across Diverse Literacy: Diagnostic Accuracy Study Background: Undiagnosed cognitive impairment poses a global challenge, prompting recent interest in ultra-brief screening questionnaires (comprising

New in JMIR Aging: An Ultra-Brief Informant Questionnaire for Case Finding of Cognitive Impairment Across Diverse Literacy: Diagnostic Accuracy Study #CognitiveHealth #MentalHealth #ScreeningTools #CognitiveImpairment #HealthcareInnovation

Clinical validation of a voice-based AI tool for screening cognitive impairment: a prospective multicenter study.
Cho, A-Hyun et al.
Paper
Details
#CognitiveImpairment #VoiceAI #ClinicalValidation

As far as I know, there are no treatments for cognitive impairment outside of B12 shots, and I have to wonder what could be given to him via IV in both hands. Possible vein collapse in one hand meant they had to go to the left hand. #cognitiveimpairment #B12 #dementia #trumphands

Global C3 lowering in adulthood protects against hippocampal dysfunction and cognitive impairment in aged mice - Molecular Neurodegeneration Advances Background Complement component 3 (C3) is increasingly recognized for its role in neurodegenerative processes; however, its specific impact on age-related hippocampal dysfunction remains poorly unders...

Global C3 lowering in adulthood protects against hippocampal dysfunction and #cognitiveimpairment in aged mice

Andre F. Batista, Jessey Presumey, Brijendra Singh...Cynthia A. Lemere @harvardmed.bsky.social #complement #neurodegeneration

link.springer.com/article/10.1...

Join #EANM #FocusMeeting7 for an in-depth discussion on how #MolecularImaging is shaping the future of #CognitiveImpairment prevention and #brain health. 🧠

📃 Programme: bit.ly/3m5gaIQ
👤 Expert panel: bit.ly/44A4Wmi
➡️ Register now: bit.ly/3Na1DZ7

Using Virtual Reality to Assess Spatial Navigation Ability in Individuals With Mild Cognitive Impairment and Older Adults: Cross-Sectional Study Background: Spatial navigation impairment is prevalent in people with Alzheimer’s disease (AD) and may appear in its initial clinical stage. To detect this deficit in people at risk may not only help to prevent them from getting lost or going missing, but also provide a useful clinical aid to accurate diagnosis. Traditional assessments for SNI include questionnaires, paper pencil and maze tests, or video games. While a real-world setting is more valid, direct, and accurate, it is plagued by unpredictable conditions such as weather, obstacles, or accidents. Thanks to modern technology, virtual reality (VR) offers a new way to test spatial navigation impairment. Objective: To test the feasibility of a VR setting to assess sense of location in people with mild cognitive impairment due to AD (AD MCI) and its power to discriminate among groups in different clinical conditions. Methods: We used PJVR to test spatial navigation ability in cognitively unimpaired (CU), subjective cognitive decline (SCD) and mild cognitive impairment due to AD (AD MCI). The PJVR is the VR version (Vive Pro Eye Head-mounted Display, HTC) of the PJ device, which has demonstrated its power to discriminate among CU, AD MCI, and mild AD. With a map provided and using joysticks or handles, participants were requested to reach five points on a 660-meter path. Linear deviation (LD) in meters from each target point and vector deviation in degrees from the direction to the start point at each point were treated as the variable for comparison. Results: 113 subjects signed informed consent and joined the study. 93 (82.3%) completed the trials, including 22 CU, 39 SCD and 32 AD MCI. Twenty, or 19.7%, failed the trials due to cyber sickness. The LD of the CU, SCD and MCI were 38.2 (39.5), mean (S.D.), 50.4 (40.7), and 100.04 (46.2) meters respectively (p

New in JMIR Aging: Using Virtual Reality to Assess Spatial Navigation Ability in Individuals With Mild Cognitive Impairment and Older Adults: Cross-Sectional Study #VirtualReality #CognitiveImpairment #AlzheimersAwareness #SpatialNavigation #AgingResearch

wtf is he babbling about? He is #unfit #cognitiveimpairment #evil #sociopath

Brain Fog? Cognitive Impairment? Which Sounds More Serious? Do you experience cognitive impairment/brain fog? I am over the term brain fog. Let’s be honest here, it is cognitive impairment.

"In the five years I’ve had my conditions, I’ve been asked MANY times about my #PainLevels. About my mobility. I do not recall EVER being asked about fatigue or #CognitiveImpairment.": buff.ly/ewwhVRd

by @limberation.com
#disability #ChronicIllness #BrainFog

A great reminder that it is not "brain fog" but #cognitiveimpairment. Here is a paper I wrote with @kirrabrean about this very topic

journals.lww.com/cptj/fulltex...

#LongCovid #PwME #MCAS #TeamClots #Migraine

Dementia risk goes down by 39% when you do one task every day Various studies have found a link between music and improved brain health and a reduction of dementia risk

⭐️🎶🎼🎵🎤🎧🎸🥁🎹🎺🎻⭐️ I do BOTH every single day! "For maximum benefit, however, listening to #music and playing an #instrument were both linked to a 33% decreased possibility of #dementia and a 22% of reduction in #cognitiveimpairment. www.irishstar.com/culture/deme...

Effect of Sodium Bicarbonate on Cognitive Function Still Unclear | Docwire News Research hinted at sodium bicarbonate, a common therapy for metabolic acidosis, having a role in cognitive impairment in chronic kidney disease (CKD), but it was not significant.

Sodium bicarbonate, a common therapy for metabolic acidosis, may have a role in cognitive impairment in CKD. #nephrology #nephsky #ckd #cognitiveimpairment #metabolicacidosis
docwirenews.com/post/effect-...

Cognitive Decline? Trump Whines About “Train to Hawaii” in Wild Rant Donald Trump invented a Democratic lawmaker who wanted to build a train to Hawaii.

#CognitiveDecline #MentalDecline #CognitiveImpairment #Dementia • #25thAmendment #RemoveTrump

Cognitive Decline? Trump Whines About “Train to Hawaii” in Wild Rant
newrepublic.com/post/201961/... via @newrepublic.com

Having a Purpose in Life Can Reduce the Risk of Dementia, New Research Finds Having a Purpose in Life Can Reduce the Risk of Dementia, New Research Finds Having a sense of purpose in life isn’t just personally fulfilling or rewarding. It turns out that it can also reduce the risk of dementia, according to research recently published in the American Journal of Geriatric Psychiatry. Conducted by researchers at the University of California Davis, the new study followed nearly 14,000 adults aged 45 […] READ: Having a Purpose in Life Can Reduce the Risk of Dementia, New Research Finds

Having a Purpose in Life Can Reduce the Risk of Dementia, New Research Finds #Health #cognitiveimpairment

Congratulatory announcement for Kenneth M. Langa with a portrait and University of Michigan logos. Text: CONGRATULATIONS Kenneth M. Langa Cyrus Sturgis Research Professor of Internal Medicine, Professor of Internal Medicine, Research Professor, Institute of Gerontology, Medical School, Research Professor, Survey Research Center, Institute for Social Research and Professor of Health Management and Policy, School of Public Health Regula Herzog Distinguished University Professor of Internal Medicine and Survey Research University of Michigan Board of Regents October 17, 2025 ISR Survey Research Center UNIVERSITY OF MICHIGAN

UM Board of Regents has honored Kenneth M. Langa with a Distinguished University Professorship.

His research shapes our understanding of #aging, #CognitiveImpairment & #dementia. He is co-director of the NIH-funded #HealthAndRetirementStudy, the largest, most influential study of aging in the U.S.

New research reveals how EEG microstates and spectral brain activity differ in patients with epilepsy + mild cognitive impairment (MCI).
Visit our site, follow us for more insights.
🔗 Link in bio
#Neuroscience #EpilepsyResearch #CognitiveImpairment #EEG #BrainHealth #MCI #NeuroTech #MCIandBeyond

Brain Fog? Cognitive Impairment? Which Sounds More Serious? Do you experience cognitive impairment/brain fog? I am over the term brain fog. Let’s be honest here, it is cognitive impairment.

““When my #BrainFog is bad I cannot process people’s #speech. I describe it as words floating past me like pretty butterflies – I hear them so know they are there, but they have no meaning.” ~ F”: buff.ly/4HciD9K

from @limberation.com
#CognitiveImpairment #cognition #disabled

Kissing bug disease linked to higher risk of cognitive impairment People with Chagas disease appear to face a greater risk of cognitive difficulties, including memory and spatial problems, compared to those with other forms of heart failure. A new study published in...

Kissing bug disease linked to higher risk of cognitive impairment #Science #HealthandMedicine #Neurology #KissingBugDisease #CognitiveImpairment #PublicHealth