We focus on #FAM136A, an orphan protein involved in familial #Menieres, an inner ear condition – not considered to be a mito disease!
We show that in #FAM136A ko:
⬇️IMS protein #CLPB #HAX1
⬇ #OXPHOS in cells, mice and patient LCLs
A #mito origin in #Menieres disease?!?
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