An updated inventory of genes essential for oxidative phosphorylation identifies a mitochondrial origin in familial Ménière’s disease Harhai and collaborators expand the catalog of genes essential for oxidative phosphorylation and implicate FAM136A in mitochondrial proteostasis. Their findings suggest a mitochondrial contribution to...

Our updated inventory of genes required for #OXPHOS & findings on #mito defects in #Menieres is now out at Cell Reports! 🎉

🧫 New galactose #CRISPR screen
🎯 481 genes required for #OXPHOS
⚙️ #FAM136A in IMS proteostasis
👂 Mito defects in #Menieres

www.cell.com/cell-reports...

First PhD manuscript preprint OUT NOW! ‼️

🧫 New galactose #CRISPR screening strategy
📝 Updated OXPHOS-regulating gene inventory
🧬 #FAM136A in the IMS
👂 Mito defects in #Ménière’s disease

All come together in our latest work available at www.biorxiv.org/content/10.1...

We focus on #FAM136A, an orphan protein involved in familial #Menieres, an inner ear condition – not considered to be a mito disease!

We show that in #FAM136A ko:
⬇️IMS protein #CLPB #HAX1
⬇ #OXPHOS in cells, mice and patient LCLs

A #mito origin in #Menieres disease?!?

3/5

New preprint from the lab! 🚨

🧫 New galactose #CRISPR screening strategy
🎯 481 genes required for #OXPHOS
⚙️ #FAM136A in IMS proteostasis
👂Mito defects in #Menieres disease

by @marcellharhai.bsky.social @fbm-unil.bsky.social

A short thread 1/5

www.biorxiv.org/content/10.1...