➡️ This important video was missing from yesterday’s #Bluetorial.

CRC organoids under treatment with KRAS inhibitor RMC-9945, rapidly acquire a LGR5+ cancer stem cell-like phenotype, allowing them to bypass KRAS inhibition, and eventually resume growth.

Centonze et al., in #CancerDiscovery

#AACR

A study published in #CancerDiscovery reveals why some colorectal cancers withstand pharmacological inhibition of #KRAS oncogene activity.

Read more here ➡️ https://bit.ly/3L0Cl2G

#CancerResearch #ColorectalCancer @batllelab.bsky.social 

🧪

My main PhD project is out in #CancerDiscovery @theaacr.bsky.social

We found that PKC activators (TPPB) destroy tumor microtube networks that glioblastoma cells use to invade & resist therapy.

Huge thanks to my first co-author @dirkchoffmann.bsky.social , @winklerlab.bsky.social & all co-authors!

@marinelab.bsky.social #CancerDiscovery

Overall cancer incidence in the U.S. among people under age 50 years was relatively flat, 2010 - 2019, while overall deaths from early-onset cancer declined, @theaacr.bsky.social #CancerDiscovery aacrjournals.org/cancerdiscov...

New data from the KRYSTAL-1 trial reveals adagrasib + cetuximab demonstrates 34% ORR and 15.9 months mOS in heavily pretreated patients with #KRAS G12C-mutated metastatic #CRC! 💊🔬

@theaacr.bsky.social #cancerdiscovery

#Onco404 #Cancer #Kanser #ColorectalCancer #ClinicalTrials #PrecisionMedicine

#ADCs represent a rapidly expanding frontier in #Oncology! This 40-year journey blends precision targeting 🎯 with potent payloads, yet challenges like toxicity and cross-resistance remind us: balance is key.

#aacr #cancerdiscovery

#Onco404 #Cancer #MedSky #OncSky #Kanser #Biotech #Innovation

BrainChild-03 Trial Supports Safety of B7-H3 CAR T-cell Therapy for DIPG Main Finding: A phase I trial supported the safety and feasibility of repeated intracranial infusions of B7-H3 CAR T cells for DIPG.Concept: B7-H3 is an immunoregulatory protein expressed on the surfa...

Honored to have our recently published first-in-human phase 1 clinical trial of repeatedly dosed intracerebroventrocular B7-H3 #CARTcells for children with #DIPG highlighted in @theaacr.bsky.social and #CancerDiscovery Research Watch ❤️🔬

Cancer Discovery - Reflections on Advances in Cancer Research in 2024 - OncoDaily Cancer Discovery - Reflections on Advances in Cancer Research in 2024 / Aadel Chaudhuri, Alejo E. Rodriguez-Fraticelli, Benjamin Izar, Brittany D. Jenkins,

Cancer Discovery – Reflections on Advances in Cancer Research in 2024
@alejofraticelli.bsky.social

oncodaily.com/blog/cancer-...

#Cancer #CancerDiscovery #OncoDaily #Oncology #Medicine #Health

9/11 First Responders Have Twofold Increase in Leukemia Precursor Firefighters and emergency medical personnel who worked at Ground Zero after the September 11 attacks are twice as likely to have clonal hematopoiesis (CH)––which, in rare cases, can lead to blood can...

Grateful to have our work presented at @ash-hematology.bsky.social #ASH24 highlighted by #cancerdiscovery, showcasing the increased risk of pre-leukemic clonal hematopoiesis in 9/11-exposed first responders. @einsteinmededu.bsky.social

aacrjournals.org/cdnews/news/...

#AACRBlog ▶️ Intersting read re: "Peto’s paradox" 🐘...and the recent #CancerDiscovery story from Compton et al. re: cancer prevalence across vertebrates!

aacrjournals.org/cancerdiscov...

Goo.gl is sunsetting

Great review on exciting future of targeting DNA repair pathways in cancer treatment. @AACR #CancerDiscovery
https://goo.gl/OoS38u

Short URL - Blocked

Biallelic BRCA1 mutations in a patient with #FanconiAnemia. New designation of BRCA as "FANC-S" in #CancerDiscovery
http://goo.gl/qCcik7