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Early recognition of subtle clues—low‑normal Hb, elevated LFTs, lower BMI—plus persistent GI symptoms and genetic risk can prompt earlier screening and diagnosis of #CeliacDisease in young adults, reducing long‑term harm.

Read in #JGIM: rdcu.be/e1mAb

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Persistent diarrhea on immunotherapy? Think beyond irAE colitis.
This case series highlights celiac disease triggered by immune-modulating drugs with important treatment implications.
🔗 https://ow.ly/5qCr50YEJXC
🏷️ #CeliacDisease #FeaturedArticle

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Travel Snacking with Gluten Restrictions: Portable, Safe Solutions for Life on the Go Whether you're heading to the airport, packing for a road trip, or just preparing for a busy day, having reliable gluten-free snacks on hand can mean the difference between thriving and just surviving.

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Little Northern Bakehouse Recipe: High-Fibre Gluten-Free Bean, Squash & Sweet Potato Salad Serve this hearty salad on its own, or pair it with gluten-free crackers, greens, or grain bowls for a complete meal.

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Pitfalls in the Diagnosis of Celiac Disease: Bridging Gaps from Serology to Clinical Practice Celiac disease is a chronic, immune-mediated enteropathy precipitated by gluten exposure in genetically predisposed individuals, with a global prevalence of approximately 1%. Though diagnostic workflows incorporate serologic techniques with both histologic and genetic evaluation, each approach carries key pitfalls that contribute to diagnostic inaccuracy. Serology testing is limited by selective immunoglobulin A deficiency and low-titer antibodies, in addition to interlaboratory variability of calibration standards and specimen concentrations. While duodenal biopsy is considered the gold standard for celiac diagnosis, patchy villous atrophy (e.g., ultrashort celiac disease) mimics other enteropathies, and the inherent subjectivity of histologic interpretation can compromise accuracy. Furthermore, celiac predisposition is highly correlated with two human leukocyte antigen (HLA) alleles, HLA-DQ2 and HLA-DQ8. However, nearly 30–40% of the general population expresses one of these alleles, thus introducing the risk of overdiagnosis and limiting the practical implications of genetic testing. There exist special celiac presentations, such as seronegative or potential celiac disease, overlap syndromes, and enteropathy-associated T-cell lymphoma, that introduce additional challenges to diagnostic success. The serologic-histologic discordance and nonspecific symptoms associated with these cases may require divergence from the traditional workflow, as well as supplemental investigations, such as a gluten challenge or breath testing, to confirm a celiac diagnosis. These challenges in celiac diagnosis have driven research into novel biomarkers and molecular assays that can not only enable earlier, more accurate detection but also provide longitudinal disease monitoring. Such markers include intestinal fatty acid-binding proteins, specific microRNA expression, and microbiome signatures that are strongly linked to celiac disease, which may one day serve as adjunctive screening tools to optimize diagnostic yield. This narrative review identifies the key pitfalls in adult celiac disease diagnosis — from pre-analytic serology issues to patchy histology and overinterpretation of HLA — and proposes a guideline-aligned, stepwise algorithm (with emerging biomarkers) to enhance accuracy and reduce missed or delayed cases. Ultimately, continued refinement of a comprehensive, multimodal diagnostic strategy that can integrate with emerging molecular tools is necessary for overcoming the current limitations of individual approaches to celiac diagnosis.

🩺 Celiac diagnosis still has traps: test while patients are on gluten, check total IgA, biopsy the bulb, and don’t overread HLA. @amcollegegastro.bsky.social
#CeliacDisease
🔗 www.xiahepublishing.com/2994-8754/JT...

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Mass. public‑health committee hears strong support for a three‑year celiac screening pilot Patients, clinicians and the Celiac Disease Foundation urged the Joint Committee on Public Health to approve H5013/S2928, which would fund a three‑year pilot adding a blood screen for celiac disease to routine lipid testing in children, paired with education and follow‑up supports.

Massachusetts is considering a groundbreaking pilot program that could revolutionize celiac disease detection in children, potentially saving lives and improving health outcomes.

Learn more here

#MA #CitizenPortal #CeliacDisease #ChildNutrition #HealthEquity

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Daura Wins Gold at the 2025 World Beer Awards: The Award-Winning Crafted-To-Remove-Gluten Beer Brand Daura continues to set the standard. Recognized as the most award-winning crafted-to-remove-gluten beer brand for its taste, the brand has recently added new international accolades to its growing list of awards.

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