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This study examined the real-world effectiveness of BNT162b2 (Pfizer-BioNTech) #COVID19vaccination in long-term care (LTC) residents, including those aged ≥95 years

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Real-world effectiveness and antibody responses of BNT162b2 vaccination in long-term care residents: a retrospective case–control study Older adults in long-term care (LTC) facilities are at high risk for COVID-19–related morbidity and mortality, yet real-world evidence on vaccine effe…

& the very elderly who were underrepresented in #clinicaltrials
This study examined the real-world effectiveness of BNT162b2 (Pfizer-BioNTech) #COVID19vaccination in long-term care (LTC) residents, including those aged ≥95 years
@jidjournal.bsky.social
www.sciencedirect.com/science/arti...

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remained at increased risk of postacute sequelae
despite administration of COVID therapeutics. These findings further suggest that #COVID19vaccination & boosting remain important in mitigating the risk of #longCOVID among immunocompromised patients during endemicity.

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COVID-19 vaccination during pregnancy may cut risk of preeclampsia A study of more than 6,500 mothers found that COVID-19 vaccination during pregnancy significantly lowered the risk of preeclampsia, a dangerous blood-pressure disorder.

#COVID19vaccination during #pregnancy may cut risk of #preeclampsia

www.livescience.com/health/repro...

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Background incidence rates and observed-to-expected ratios of adverse events of special interest after covid-19 mRNA vaccination during pregnancy in France: a nationwide population-based study This work did not evidence any safety signal after mRNA vaccination against COVID-19 for AESI during pregnancy. It contributes to the growing body of evidence regarding its safety.

Nationwide study in France is the first to examine adverse events of special interest following #COVID19Vaccination during #pregnancy

www.thelancet.com/journals/lan...

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COVID-19 vaccination significantly reduces risk to pregnant women and baby – BioNews Central New research based on nearly 20,000 pregnancies across Canada shows that women who received a COVID-19 vaccine were far less likely to experience severe illness or deliver their babies prematurely. ...

New research based on nearly 20,000 pregnancies across Canada shows that #women who received a #COVID19vaccine were far less likely to experience #SevereIllness or deliver their #babies prematurely.
#COVID19Vaccination #Pregnancy #COVID19Severity 

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Vaccination and Maternal and Perinatal Outcomes Associated With COVID-19 in Pregnancy This study uses a population-level surveillance program to investigate maternal and perinatal outcomes associated with SARS-CoV-2 infection in pregnancy by vaccination status prior to and during pregn...

#Medsky🧪 #IDsky #pedsky #publichealth in This study (n = 19 899) demonstrated that among pregnant women with #COVID , #COVID19vaccination is associated with a lower risk of severe disease & preterm birth regardless of variant time period.
@jama.com
jamanetwork.com/journals/jam...

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in the brains of mice with spike S1 injection & stroke.
- #Covid19Vaccination reduced but did not eliminate s protein accumulation #postCOVID infection in 🐁 🧠 .
🔥The study provides several lines of evidence suggesting activation of the immune response in the skull-meninges 🧠axis during #COVID :

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🔥May be partly reversed in late clinical phases or following #COVID19vaccination, which has been shown to decrease epigenetic age in older individuals

www.sciencedirect.com/science/arti...
- www.sciencedirect.com/science/arti...

www.tandfonline.com/doi/full/10....

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PMMA dialyzers modulate both humoral and cell-mediate immune response to anti-COVID-19 vaccine (BNT162b2) in a cohort of chronic hemodialyzed patients - Scientific Reports Scientific Reports - PMMA dialyzers modulate both humoral and cell-mediate immune response to anti-COVID-19 vaccine (BNT162b2) in a cohort of chronic hemodialyzed patients

- International guidelines recommend prioritizing #COVID19vaccination in this vulnerable cohort
@nature.com
www.nature.com/articles/s41...
-Immunological senescence and altered immune responses to infection and vaccination are common in ESRD patients,

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#Medsky #IDsky #immunosky #publichealth Tattoo Ink Alters the Immune Response to #COVID19Vaccination.

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Post-COVID conditions following COVID-19 vaccination: a retrospective matched cohort study of patients with SARS-CoV-2 infection - Nature Communications The impact of COVID-19 vaccination on post-COVID conditions is not well understood. Here, the authors use electronic health record data from a network of eight integrated healthcare systems in the Uni...

while unvaccinated individuals remain at higher risk for severe GI complications mortality associated with COVID . Overall, the evidence suggests that #COVID19vaccination not only mitigates the severity of acute COVID diagnosis ,

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Frontiers | Impact of BNT162b2 mRNA Vaccination on the Development of Short and Long-Term Vaccine-Related Adverse Events in Inflammatory Bowel Disease: A Multi-Center Prospective Study Abstract IntroductionSARS-CoV-2 vaccination has been effective in protecting against severe COVID-19 infections and related mortality. It is recommended for ...

No evidence has emerged of IBD flare-ups caused by #COVID19vaccination
www.frontiersin.org/journals/med...

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Based on a large-scale 🇬🇧 population cohort study, #COVID19vaccination was associated with a reduced risk of developing new-onset IBD following infection. Other studies show vaccination helps reduce acute GIT symptoms during a COVID infection & LC- GIT symptoms

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#Medsky🧪 #IDsky #immunosky #publichealth Challenges & Considerations for Long-Term #MucosalImmunity from mucosal viral infections elicit long-lived IgA responses through type 1 follicular helper T cells, particularly in the context of #COVID19vaccination

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Impact of systemic SARS-CoV-2 vaccination on mucosal IgA responses to subsequent breakthrough infection Mucosal IgA responses are central to protection against SARS-CoV-2 infection and viral transmission. While systemic immunity following SARS-CoV-2 infe…

- Intramuscular (IM) #COVID19vaccination induces modest mucosal IgA responses in adults, which may be boosted by hybrid immunity (prior infection plus vaccination)

www.sciencedirect.com/science/arti...

www.sciencedirect.com/science/arti...

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Although #COVID19vaccination also induces mucosal IgG to S protein, nasal IgG after parenteral vaccination is likely not due to local production but primarily the result of active transport of serum IgG via the #neonatal Fc receptor
www.frontiersin.org/journals/imm...

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with calls for vaccine policies to consider these benefits alongside the prevention of acute disease, especially in younger & healthier populations while most evidence supports a protective effect of #COVID19vaccination against LC, esp with 2 or more doses,

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Hybrid Immunity Significantly Reduces Long COVID Risk in Health Care Workers COVID-19 vaccination, especially with prior infection, significantly reduced the risk for long COVID in health care workers.

#COVID19vaccination, particularly when combined with prior infection, substantially reduces the risk for #longCOVID among #HCWs. Published in @cidjournal.bsky.social and @infectiousdisease.bsky.social.

https://bit.ly/43HuFc5

#COVID19

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Frontiers | T-cell immunity to SARS-CoV-2: what if the known best is not the optimal course for the long run? Adapting to evolving targets Humanity did surprisingly well so far, considering how unprepared it was to respond to the coronavirus disease 2019 (COVID-19) threat. By blending old and in...

the immune system still retains a functional & durable memory + complement #COVID19vaccination that prevents the most severe outcomes of subsequent #COVID encounters.

www.frontiersin.org/journals/imm...

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- In children, behavioral changes, dysphagia & chest tightness at #COVID diagnosis were associated more neuropsychiatric symptoms
- In adolescents, imbalance, dizziness, & diarrhea were linked to greaterom burden.
- #COVID19Vaccination was associated with lower rates of brain fog, memory deficit,

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very few studies found a causative relationship between #COVID18vaccination & neurodegenerative disorders. One possible, but not well-proved relationship to #COVID19vaccination is to #GuillainBarrésyndrome, an autoimmune disorder with symptoms that include muscle weakness.

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to the Pfizer mRNA Vaccine
- In an immunocompromised population, studyfound that physically active participants had better responses to #COVID19vaccination vs to relatively inactive participants. These data support the contention that PA people mount better immune responses than sedentary people.

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With respect to #COVID19vaccination, recently reported that a single 90 minute cardiovascular aerobic exercise session immediately after vaccination improved IgG responses

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As conclusions, N-95 😷 & #COVID19vaccination are essential to protect you and your loved ones. There’s no point in living with the suffering of Long COVID, full of pain.

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- The study were unable to account for the potential of influenza or #COVID19vaccination due to lack of data on vaccination status.
- Further validation is warranted in broader geographic regions, over extended time frames & in more diverse populations.

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Long COVID and the development of new-onset uveitis: a large database study - Journal of Ophthalmic Inflammation and Infection Purpose To determine the impact of long COVID diagnosis on the risk of developing uveitis among individuals vaccinated and not vaccinated against COVID. Methods We conducted a population-based retrosp...

In contrast, vaccinated LC individuals did not show an ⏫️ risk vs to vaccinated individuals without LC
The findings suggest that #COVID19vaccination may offer protection against developing new-onset uveitis as a long-term complication of #COVID

joii-journal.springeropen.com/articles/10....

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COVID-19 vaccination reduces risk of ‘long COVID’ in adults COVID-19 vaccination reduced the risk of developing ‘long COVID’ by approximately 27% in adults fully vaccinated before infection, according to a literature review carried out by the European Centre f...

📍 #COVID19vaccination significantly reduces the risk of severe disease & #postcovid complications, including new-onset #diabetes.

www.cedars-sinai.org/newsroom/ver...

www.endocrinologyadvisor.com/news/covid-1...

@ecdc.europa.eu
www.ecdc.europa.eu/en/news-even....

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Other findings indicate that #COVID19vaccination is associated with a lower incidence of some posterior segment complications in patients who contract #COVID.
@nature.com
www.nature.com/articles/s41...
- Compared to Flu patients , those with #COVID

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Highlights

Highlights

#Medsky🧪 #IDsky #Immunosky #publichealth @cidjournal.bsky.social
Effectiveness of #COVID19vaccination and prior infections to reduce #longCOVID risk during the pre-Omicron and Omicron periods .

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