Nanoscale Horizons Emerging Investigator Series: Dr Shelly Conroy, Imperial College London, UK pubmed.ncbi.nlm.nih.gov/41954015/ #cryoEM

Model-dependent and model-independent visualization of hydrogen atoms in high-resolution cryoEM maps pubmed.ncbi.nlm.nih.gov/41954135/ #cryoEM

Evaluating the Volta phase plate for improved tomogram alignment in cryo-electron tomography pubmed.ncbi.nlm.nih.gov/41954506/ #cryoEM

The tRNA moieties of both aminoacyl-tRNA substrates of a cyclodipeptide synthase share a common binding site, as revealed by RNA microhelices mimicking tRNA acceptor arms pubmed.ncbi.nlm.nih.gov/41954980/ #cryoEM

Allosteric activation mechanism of the type VII CRISPR-Cas system pubmed.ncbi.nlm.nih.gov/41954985/ #cryoEM

Structure of human lymphoid-specific helicase HELLS in its autoinhibited state pubmed.ncbi.nlm.nih.gov/41954988/ #cryoEM

Human monoclonal antibodies that target the SFTSV glycoprotein Gn head from four neutralizing epitope groups pubmed.ncbi.nlm.nih.gov/41955097/ #cryoEM

Structure-guided design of 7-azaindole DNMT1 inhibitors active against hypomethylating agent-resistant acute myeloid leukemia pubmed.ncbi.nlm.nih.gov/41955111/ #cryoEM

MDFIC2 is a sensory neuron-specific PIEZO channel auxiliary subunit pubmed.ncbi.nlm.nih.gov/41955114/ #cryoEM

Assembly and phosphoregulatory mechanisms of the budding yeast outer kinetochore KMN complex pubmed.ncbi.nlm.nih.gov/41956986/ #cryoEM

Species- and variant-specific ACE2 compatibility shapes SARS-CoV-2 spillover potential in North American cervids pubmed.ncbi.nlm.nih.gov/41957014/ #cryoEM

Complete inhibition of β-tryptase by tetramer dissociation and active site allostery due to a single antibody residue pubmed.ncbi.nlm.nih.gov/41957026/ #cryoEM

@noahnturner.bsky.social, Barford et al reveal conserved underlying mechanisms of complex assembly, auto-inhibition, & phosphoregulation that ensure precise control of KMN assembly onto #centromeres to enable genome division. rupress.org/jcb/article/...

#kinetochores #cryoEM #biochemistry #genetics

Structural basis for TRF2-RAP1 recruitment by EBNA1 at the EBV origin of replication pubmed.ncbi.nlm.nih.gov/41957069/ #cryoEM

We determined #cryoEM structures of alpha-synuclein filaments from individuals with mutations A53T, G51D and H50Q, as well as those of the homozygous M83 mouse, which is transgenic for human A53T alpha-synuclein.

8th Instruct | FRISBI | PSB Grenoble Cryo-EM Course on Sample Preparation <p><img src="https://instruct-eric.org/upload/nOyS9ZN04jpBMHRN82vhcPbOmNcSlgQa.png" /></p> <p>We are pleased to announce the eighth hands-on practical course on sample preparation for single-particle…

Deadline closing this Sunday!
Instruct | FRISBI | @psb-grenoble.bsky.social Cryo-EM Course on Sample Preparation
📅 19 – 22 May 2026
📍 European Photon and Neutron Campus, Grenoble, France
🔗 instruct-eric.org/events/8th-i...

#CryoEM #Training

Today we are at the NESBA "Designing Structure: Protein Therapeutics and Vaccines" symposium in Cambridge, Massachusetts - Stop by our table and chat with Rachel and Joyce - Learn about our latest tools and instruments for #cryoem & #crystallography

Development of a clinically viable MRGPRX4 inverse agonist for cholestatic itch treatment pubmed.ncbi.nlm.nih.gov/41957282/ #cryoEM

Best 3D reconstruction so far from this Tundra dataset. Right shape with some hints of secondary structure. Data collected at a higher magnification will hopefully improve this. @nusbf.bsky.social #cryoEM

Linker histone H1 represses H3 tail acetylation induced by H4 tail acetylation and alters its dynamics pubmed.ncbi.nlm.nih.gov/41957285/ #cryoEM

Here you can see a cryoEM structure of the human NHEJ Long-range synaptic complex (PDB code: 7LT3)

Rendering by Francisco J. Enguita made with #ProteinImager

#SciArt #molecularart #cryoem #NHEJ #complex #DNArepair #joining

Mode of action guided metagenomic natural product discovery reveals convergent evolution of a ClpP-targeting motif pubmed.ncbi.nlm.nih.gov/41957365/ #cryoEM

Direct Membrane Penetration of Oligoarginines by Fluorescence and Cryo-electron Microscopy Combined with Molecular Simulations www.biorxiv.org/content/10.64898/2026.04.07.716952v1 #cryoEM

Scientific Database Curator Your role We are looking to recruit an expert structural biologist with an experimental background to join the EMDB as a biocurator within the EMBL-EBI OneDep data curation team. High-quality…

🚨Job opening 🚨: In 2020, cumulatively 10,000 #cryoEM structures had been resolved. By 2025, 10,000 #cryoEM structures were determined within a single year. Join the international effort making all this data available. OneDep biocurator on the EMDB team: embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

Time-resolved cryo-EM reveals conformational trajectory of allosteric activation in isocitrate lyase www.biorxiv.org/content/10.64898/2026.04.08.716820v1 #cryoEM

Lysosome-related organelles orchestrate guanine crystal formation in pigment cells pubmed.ncbi.nlm.nih.gov/41950095/ #cryoEM

Ligand-driven modulation of chaperone-cochaperone networks shapes proteostasis outcomes pubmed.ncbi.nlm.nih.gov/41949208/ #cryoEM

In situ architecture of developmentally programmed mitophagy reveals ER-phagophore membrane continuity pubmed.ncbi.nlm.nih.gov/41949493/ #cryoEM

Structure basis for C-C chemokine receptor 4 modulation by orthosteric and allosteric antagonists pubmed.ncbi.nlm.nih.gov/41950080/ #cryoEM

Cetacean coronavirus spikes highlight S glycoprotein structural plasticity pubmed.ncbi.nlm.nih.gov/41950284/ #cryoEM