Researchers identify #DDX39B as a driver of #NSCLC #metastasis via TRIM28-mediated stabilization and ECAD degradation, revealing #artesunate as a promising therapy that disrupts DDX39B-TRIM28, suppressing #βcatenin signaling. #medsky

#OpenAccess in #STTT: doi.org/10.1038/s413...

Structures and mRNP remodeling mechanism of the TREX-2 complex Xie et al. demonstrate that the TREX-2 complex facilitates DDX39B/Sub2 unloading during nuclear mRNP remodeling. The authors present crystal and cryo-EM structures of the TREX-2/Sub2 complex and show ...

#mRNA #Export #Sub2 #DDX39B #TREX-2

www.cell.com/structure/ab...