New research article
Parasite clearance in patients with #Plasmodium #vivax monoinfection treated with #artesunate in Cambodia: an observational secondary analysis of trial data
www.thelancet.com/journals/lan...
#IDSky #ClinMicro #malaria #AMR #OpenAccess #OA
#Artesunate suppresses #HCC by engaging GBA to activate a GBA–ceramide–CTSD–BID–BAX apoptotic cascade, and shows that mutational disruption of this interface abolishes signaling, defining a structural basis for future GBA-targeted therapies.
#OpenAccess: doi.org/10.1016/j.ge...
Researchers identify #DDX39B as a driver of #NSCLC #metastasis via TRIM28-mediated stabilization and ECAD degradation, revealing #artesunate as a promising therapy that disrupts DDX39B-TRIM28, suppressing #βcatenin signaling. #medsky
#OpenAccess in #STTT: doi.org/10.1038/s413...
Anyone know the actual market status of #artesunate in Canada? Since submitted as a Priority Review, presumably Health Canada's "expectation that sponsors requesting Priority Review status market the product in a timely fashion, i.e. within 60 days" after approval in July applies?
Also: Price?
Screenshot of the paragraph "Pricing Plan" from this Amivas document: https://ago.vermont.gov/sites/ago/files/wp-content/uploads/2021/10/Vermont-Notification_20Aug2021.pdf
Happy #WorldMalariaDay.
#Artesunate is currently under review by Health Canada (a mere 25yrs after being added to WHO's #EssentialMedicines List).
Once approved, one suspects Amivas will adopt pricing closer to their US strategy (⬇️) than the $1-3 Global Fund reference price for the same drug.
Enhanced Photothermal/Immunotherapy under NIR Irradiation Based on Hollow Mesoporous Responsive Nanomotor | Inorganic Chemistry pubs.acs.org/doi/10.1021/... Lv and co-workers @InorgChem #copper #sulfide #artesunate #hyaluronicacid #nanomotor #hollow #NIR #photothermal #immunotherapy
Screenshot of Health Canada new drug submissions list showing artesunate.
In the nanosecond that severe #malaria makes global headlines:
With cases every year, Canada uses an elaborate severe malaria-specific workaround to access non-marketed #EssentialMedicines, as the usual pathway is too slow for emergencies.
"New" drug submission for #artesunate finally filed in 2024!
Image of artesunate in list of Canadian drug applications
Catching up on Health Canada drug approval applications; looks like there's finally one for #artesunate for #malaria.🦟
Canada already built an elaborate bureaucratic workaround for artesunate to avoid access delays associated with its usual mechanism (Special Access Program) for unlicensed drugs.💊🌐
Update on severe #malaria treatment: the @CDCgov will be holding a webinar Thurs 3/28 discussing IV #artesunate access! A chance to discuss directly with the source when all quinidine expires in 10 days
Update on severe #malaria treatment: the @CDCgov will be holding a webinar Thurs 3/28 discussing IV #artesunate access! A chance to discuss directly with the source when all quinidine expires in 10 days
