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#
Hashtag
#DKK3
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Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
@sigtrans-sttt.bsky.social
1 month ago
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Researchers identify #DKK3 as a driver of radiation-induced #SkinFibrosis, where keratinocyte DKK3 promotes ROS, TGF-β/Wnt signaling, and M2 #MacrophagePolarization; DKK3 deficiency reduces dermal hyperplasia and fibrosis. @dkfz.bsky.social @umich.edu

#STTT: doi.org/10.1038/s413...

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Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
@sigtrans-sttt.bsky.social
2 months ago
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#DKK3 emerges as a regulator of #radiation‑induced #SkinInjury, elevating #ROS, activating TGF‑β/Wnt signaling, driving #M2macrophage polarization, and promoting #fibrosis—while its deficiency reduces dermal damage. @dkfz.bsky.social @umich.edu

#STTT: doi.org/10.1038/s413...

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