Safety and immunogenicity of an HIV vaccine trial with DNA prime and replicating vaccinia boost - Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy - Safety and immunogenicity of an HIV vaccine trial with DNA prime and replicating vaccinia boost

Replication-competent vaccinia Tiantan-based #HIV candidate vaccine combined with a #DNAvaccine component exhibits promising safety & tolerability profiles while eliciting a robust #ImmuneResponse against #HIVantigens. #medsky

#STTT #OpenAccess: doi.org/10.1038/s413...

A New Era for DNA Vaccines? Imunon’s PlaCCine DNA Platform The global response to the COVID-19 pandemic highlighted the incredible power of nucleic acid vaccines, particularly the rapid development and deployment of mRNA vaccines. However, it also brought to ...

Can DNA vaccines overcome the cold-chain and reactogenicity problems of mRNA? Imunon’s PlaCCine platform just might. Strong T-cell immunity, easy delivery, and protection against Omicron in animal models. go.njmicrobe.org/EXvoFy #DNAVaccine #Imunon #COVID19 #GlobalHealth #NJBiotech

🧫 Can a DNA vaccine stop Klebsiella?

At Univ. of Girona, López Siles’ team is developing KlebsiGene to prevent drug-resistant infections.
With ISIDORe/EATRIS, they confirmed no DNA integration & began transcriptome analysis.

#ISIDORe #Klebsiella #DNAVaccine #AMR #VaccineDevelopment

🧫 KlebsiGene: a DNA vaccine against Klebsiella.

López Siles (Univ. of Girona) advanced regulatory strategy & safety validation with ISIDORe, EATRIS & FIMM.

✔️ TPP defined
✔️ No DNA integration
✔️ Transcriptomics ongoing
#ISIDORe #DNAVaccine #AMR #Klebsiella #VaccineDevelopment