#DelayedDiagnosis of alpha-mannosidosis is common especially in mild cases, highlighting the need for early diagnosis to facilitate timely treatment bit.ly/4oTXxpC #GIMO #AlphaMannosidosis #LysosomalStorageDisorder #DiseaseSeverity #RareDisease #EnzymeReplacementTherapy

3/5 Disease was moderate but not lethal: Ferrets had fever, lethargy, sneezing, nasal discharge and 9.8% weight loss but all survived 21 days. Virus primarily in respiratory tract with limited spread to brain/GI tissues. Peak viral shedding 4.7-5.4 log₁₀ PFU/mL.
#ViralShedding #DiseaseSeverity

3/9 Unlike historical H5N1 strains with 52% case fatality rates, current clade 2.3.4.4b infections in humans are generally mild. However, the virus has caused severe disease in some patients, including a teenager in Canada and two older adults in the US.
#DiseaseSeverity #Zoonosis #H5H1 #BirdFlu