4/4: With @elisajentho
#DiseaseTolerance #EvolutionaryMedicine #AntagonisticPleiotropy
@gimmfoundation.bsky.social

With @elisajentho
#DiseaseTolerance #EvolutionaryMedicine #AntagonisticPleiotropy

Plasmodium falciparum infection induces T cell tolerance that is associated with decreased disease severity upon re-infection | Journal of Experimental Medicine | Rockefeller University Press Sandoval et al. show that a single malaria episode reprograms T cell activation to minimize cytotoxicity and injury during subsequent infections. This adap

#TuesdayReads:
Draper Group et al reveal how disease tolerance to malaria develops after just one infection—reprogramming T cell responses to reduce inflammation without compromising memory.

rupress.org/jem/article/...

#Malaria #Immunology #DiseaseTolerance #TCellResponse @kavlifoundation.org

New immune mechanism discovered to protect the gut A research team from Canada, with the participation of Sebastian Weis’ group from the Leibniz-HKI and the Univer…

How does the gut stay healthy during worm infections? 🛡️🪱 A new Canadian-German study in #Cell shows #interferons help protect tissue. Not by killing worms, but by boosting gut resilience!

🗞️ News article: lmy.de/qMldA
💡Publication: lmy.de/wcghm

#DiseaseTolerance #InfectionBiology #LeibnizHKI

β-Glucan reprograms neutrophils to promote disease tolerance against influenza A virus - Nature Immunology Divangahi and colleagues report that β-glucan pretreatment before influenza A virus challenge can increase survival by inducing long-term reprogramming of neutrophils, promoting disease tolerance irre...

Nargis Khan and Maz Divangahi show that β-glucan reprograms HSCs in the bone marrow to generate ‘regulatory’ neutrophils (IL-10hi) which are required for promoting #diseasetolerance and lung tissue integrity against IAV challenge. [1/n]

www.nature.com/articles/s41...

#TrainedImmunity #RegNeuts

(4/5)
We expect this experimental framework will prove useful in disentangling the relative roles of #diseasetolerance (to pathogen-induced damage) and #resistance during infections, not only in this #host-#pathogen system but across different species

I am very happy to see this first part of my PhD work go online now! 💃🏾 We explored alternative strategies to elicit #diseasetolerance in #Drosophila melanogaster in response to oral #infection with a natural bacterial #pathogen, #Pseudomonas entomophila. (Thread)

Depending on resource availability, "a combined strategy, strongly weighted towards tolerance but also including some low-level investment in resistance, universally outperformed all lone strategies".
#HostPathogen #DIseaseTolerance