URE patients had a median of six failed treatment strategies, including surgery or neurostimulation.
doi.org/10.1002/epi4...
#epilepsy #ILAE #epilepsiaopen #antiseizuremedication #drugresistantepilepsy #neurostimulation #resectivebrainsurgery #ultrarefractoryepilepsy
Interrater agreement of retrospective chart reviews is highly dependent upon documentation quality.
doi.org/10.1111/epi....
#epilepsy #ILAE #epilepsia #datareporting #drugresistantepilepsy #interraterreliability #neuromodulation #vagusnervestimulation
#wearablehealthcare #epilepsy #mjnneuro #AI #wearabledevice #seizures #Episeras #mjnSERAS #medicaldevice #Neuraxpharm #drugresistantepilepsy #Bluetoothenabledearpiece #seizureriskdata #digitalhealthsolution #SERASHome_RWD #beyondthepill #EITHealth #Horizon2020programme
zurl.co/OKnrk
Cenobamate demonstrates sustained seizure freedom and a favorable safety profile in patients with drug-resistant epilepsy.
doi.org/10.1111/epi....
#epilepsy #ILAE #epilepsia #antiepileptic #cenobamate #drugresistantepilepsy #seizurefreedom
This is a pediatric case series of patients suffering from multifocal or generalized drug-resistant epilepsy treated with centromedian RNS.
doi.org/10.1002/epi4...
#epilepsy #ilae #epilepsiaopen #centromediannucleus #thalamus #drugresistantepilepsy #pediatric #responsiveneurostimulation
We utilized open-source tools to analyze interictal biomarkers: high-frequency oscillations and phase–amplitude coupling.
doi.org/10.1111/epi....
#Epilepsy #ILAE #epilepsia #drugresistantepilepsy #intracranialEEG #modulationindex #neuromodulation
We highlight the dual imperative of driving forward innovations in neurotechnologies while prioritizing patient safety.
doi.org/10.1111/epi.... Open Access
#epilepsy #ilae #epilepsia #normalizationofdeviance #neuromodulation #drugresistantepilepsy #safety #ethics
We conducted a translation and back-translation methodology to obtain a Spanish version of the Epilepsy Surgery Satisfaction Questionnaire-19 (ESP-ESSQ_19).
doi.org/10.1111/epi....
#epilepsy #ilae #epilepsia #drugresistantepilepsy #epilepsysurgery #patientsatisfaction #qualityoflife
Although most became eligible to drive after VNS implantation without significant medication changes, some required additional medication changes to achieve seizure control.
doi.org/10.1002/epi4...
#epilepsy #epilepsiaopen #ILAE #driving #drugresistantepilepsy #vagusnervestimulation #VNS
Neuropsychological assessment can aid stereo-EEG planning and support individualized counseling of cognitive and psychological outcomes.
doi.org/10.1002/epi4...
#epilepsy #ILAE #epilepsiaopen #cognitivemapping #drugresistantepilepsy #neuropsychological #assessment #rehabilitation #RFTHC #SEEG
One-third of people with epilepsy continue to have seizures despite new anti-seizure medications.
doi.org/10.1002/epi4...
#epilepsy #epilepsiaopen #ILAE #Delphiconsensusstudy #drugresistantepilepsy #DRE #epilepsymanagement #uncontrolledepilepsy
DBS in ATN and hippocampus showed similar long-term seizure reduction.
doi.org/10.1002/epi4...
#epilepsy #epilepsiaopen #ILAE #anteriorthalamicnucleusDBS #cognition #deepbrainstimulation #drugresistantepilepsy #hippocampalDBS
Our findings reveal significant pulvinar involvement in most seizures, particularly those originating from the temporal lobe, identifying the PuM as critically involved in these seizures.
doi.org/10.1111/epi....
#epilepsy #ILAE #epilepsia #deepbrainstimulation #drugresistantepilepsy #pulvinar
Our results offer guidance for EEG preprocessing choices to advance the treatment of drug-resistant focal epilepsy.
doi.org/10.1111/epi....
#epilepsy #epilepsia #ILAE #closedloopneurostimulation #drugresistantepilepsy #EEG #energyconsumption #neuralnetworks #seizuredetection
SEEG-RFTC is a safe and effective option for reducing seizures in patients with complex networks or surgically inaccessible regions.
doi.org/10.1111/epi....
#epilepsy #ilae #epilepsia #drugresistantepilepsy #epilepsysurgery #radiofrequency thermocoagulation #SEEGguided #stereotactic
Corpus callosotomy was shown to be an effective long-term measure to decrease seizure burden in adults with drug-resistant epilepsy
doi.org/10.1002/epi4...
#epilepsy #ilae #epilepsiaopen #corpuscallosotomy #drugresistantepilepsy #epilepsysurgery #LennoxGastautsyndrome
This multicenter prospective study examined how seizure frequency and severity relate to long-term health-related quality of life after VNS.
doi.org/10.1111/epi....
#epilepsy #epilepsia #ILAE #drugresistantepilepsy #epilepsysurgery #pediatricepilepsy #qualityoflife #vagusnervestimulation
This study explored whether highly purified Cannabidiol (Epidiolex®) could help manage drug-resistant seizures in people with RTT or CDD.
doi.org/10.1002/epi4...
#epilepsy #ilae #epilepsiaopen #cannabidiol #CDKL5deficiencydisorder #drugresistantepilepsy #Rettsyndrome
This review provides a foundation to guide future studies to standardize the measurement of neuropsychological/neurobehavioral outcomes in patients with RNS.
doi.org/10.1111/epi....
#epilepsy #epilepsia #ILAE #cognition #depression #drugresistantepilepsy #memory #neuromodulation #neurostimulation
Microburst VNS reduces seizure frequency in drug-resistant epilepsy.
doi.org/10.1002/epi4...
#epilepsy #ilae #epilepsiaopen #drugresistantepilepsy #microburstvagusnervestimulation #neuromodulation #restingstatefMRI #thalamus
KDT normalizes rigid brain dynamics in DRE by altering state transitions.
doi.org/10.1111/epi....
#epilepsy #epilepsia #ILAE #braindynamics #drugresistantepilepsy #fMRI #ketogenicdiet
19 patients. 0 seizures.
This Canadian case series documents seizure freedom in every single patient with drug-resistant epilepsy, using #cannabis oil prescribed by licensed medical professionals.
💜 Real outcomes. Real science. 💜
#CannabisOil #Epilepsy #SeizureFreedom #DrugResistantEpilepsy #DRE
Stimulation frequencies of 10 Hz and >90 Hz led to a reduction in brain FC, whereas frequencies between 20 and 80 Hz were associated with an increase in FC.
doi.org/10.1111/epi....
#epilepsy #epilepsia #ILAE #DBS #drugresistantepilepsy #functionalconnectivity #neuromodulation #SEEG
Key point: This study compared the differences between high pulse amplitude mode and high duty cycle mode.
doi.org/10.1002/epi4...
#epilepsy #epilepsiaopen #ILAE #drugresistantepilepsy #efficacy #programmingprotocol #vagusnervestimulation
Key point: Deep brain stimulation of the centromedian nucleus of the thalamus is an off-label, investigational treatment for DRE in children.
onlinelibrary.wiley.com/doi/10.1111/...
#epilepsy #Ilae #epilepsia #centromediannucleus #deepbrainstimulation #drugresistantepilepsy #qualityoflife
Key point: Several newer antiseizure medications, including the most recent, cenobamate, are now available for the treatment of focal epilepsy.
doi.org/10.1111/epi....
#epilepsy #ILAE #Cenobamate #SKlifescience #antiseizuremedications #drugresistantepilepsy #focalepilepsy
Key point: Epilepsy surgery is effective for children with high-grade brain tumors.
onlinelibrary.wiley.com/doi/full/10....
#epilepsy #ilae #children #drugresistantepilepsy #epilepsysurgery #highgradebraintumors #seizurefreedom
Key point: Cenobamate significantly reduces seizure frequency and shows high retention rates.
doi.org/10.1111/epi....
#epilepsy #ILAE #antiseizuremedications #cenobamate #drugresistantepilepsy #focalseizures #realworld
Key point: Low glycemic index treatment (LGIT) may be non-inferior to the modified Atkins diet (MAD).
doi.org/10.1111/epi....
#epilepsy #ILAE #drugresistantepilepsy #ketogenicdiet #lowglycemicindex #treatment #modifiedatkinsdiet
Key point: Cenobamate is a promising and safe treatment for SCN8A-related DEEs, even during early childhood.
doi.org/10.1111/epi....
#epilepsy #ILAE #drugresistantepilepsy #geneticepilepsy #sodiumchannelopathy #DEE
