Researchers identify #FGFR1 as a driver of poor survival in #Glioblastoma and introduce CYY292, which that suppresses proliferation, EMT, invasion, and stemness via FGFR1/AKT/Snail signaling, outperforming AZD4547 & prolonging survival in GBM models.

#OpenAccess: doi.org/10.1016/j.ge...

In J. Comput.-Aided Mol. Des. Nagare et al. (2025) developed robust QSAR models for FGFR-1 inhibitors, combining computational & experimental validation.
Descriptors from #alvaDesc
🔗 alvascience.com/alvadesc/
📄 doi.org/10.1007/s108...

#QSAR #cheminformatics #FGFR1 #drugdiscovery #chemsky

FGFR1-amplified colorectal cancer: a distinct prognostic subtype identified through integrated genomic and immunohistochemical profiling Fibroblast growth factor receptor (FGFR) alterations are established therapeutic targets in cholangiocarcinoma and urothelial carcinoma but remain understudied in colorectal cancer (CRC). This study i...

💡 Clinical Tip: FGFR1 amplification defines a high-risk CRC subset. IRS-based IHC scoring may serve as practical biomarker to identify candidates for novel FGFR1-targeted strategies.

#ColorectalCancer #FGFR1 #Biomarkers #PrecisionOncology #OncoTwitter #Medicalwatch
www.esmoopen.com/article/S205...

🙏🙏Thanks🙏🙏@oncodaily.bsky.social and @elisabettabonzano.bsky.social for highlighting our recent paper on #HER3/NRG1 and #FGFR1 signaling in #CTC from #brestcancer patients published in @naturecancer.bsky.social @dkfz.bsky.social

Here the link 👇👇👇👇

rdcu.be/d61IZ

Luigi Luigidaweb GIF ALT: Luigi Luigidaweb GIF

We then deeply investigated the vulnerabilities and molecular regulators of VC-Resist with the hope of targeting this invasive and resistant cell state in the future. #YAP1 #FGFR1 (5/11)