Developing serum proteomics based prediction models of disease progression in ADPKD - PubMed Autosomal Dominant Polycystic Kidney Disease is the most common genetic cause of kidney failure. Outcome prediction is essential to guide therapeutic decisions. However, currently available models…

New discovery: FHR1, a complement system protein, plays a surprising role in helping macrophages clear dead cells (efferocytosis). #FHR1 #Immunology #Macrophages #Proteomics #Biotech #ComplementSystem #SingleCell
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Factor-H-related protein 1 (FHR1), a promotor of para-inflammation in age-related macular degeneration - Journal of Neuroinflammation Age-related macular degeneration (AMD), a multifactorial type of retinal degeneration represents the most common cause for blindness in elderly. Polymorphisms in complement factor-H increase, while ab...

In age-related #macular degeneration, #FHR1 accumulates below the retinal pigment epithelium, stabilizes and activates mononuclear #phagocytes → degeneration. bit.ly/4lwjXfD [open access]