Multiple Protein Structure Alignment at Scale with FoldMason Protein structure is conserved beyond sequence, making multiple structural alignment (MSTA) essential for analyzing distantly related proteins. Computational prediction methods have vastly extended ou...

Some very nice multiple protein alignment software based on predicted structure brought to you by the folks behind #MMseqs and #FoldSeek ... Gotta try out FoldMason!!

www.biorxiv.org/content/10.1...

On 310 Copilot, you can open the Actions box and, by clicking the #FoldSeek button, quickly perform accurate and sensitive comparisons of large protein structure sets, supporting monomer and multimer searches.

A screenshot of the results table of a Foldseek search on SubtiWiki. It shows multiple entries and corresponding metrics. One of the rows is expanded, revealing a 3D visualization of a superimposition of the target and the query structure corresponding to the search hit.

Try out our integration of the amazing protein structure search tool #Foldseek on #SubtiWiki (subtiwiki.uni-goettingen.de/foldseek)! Just upload a structure or use PDB/AlphaFoldDB entries to find similar structures. #IMPRS-GS #UniGoettingen
#alphafold #bacillus #subtilis

we tried to fill this gap in knowledge, by:
1) identifying conserved proteins by #ProteinFolding & matching #FoldSeek
2) review their roles & #ProteinStructure #AlphaFold3
3) Propose a model for the G+ T4SS from #Enterococcus
Check out our work to learn more!
#StructuralBioinformatics #AIinScience