New evidence shows SLBP enhances SARS-CoV-2 replication by promoting –1 ribosomal frameshifting.
#SARSCoV2 #Frameshifting #ViralReplication #HostFactors #CoronavirusResearch
www.nature.com/articles/s41...

This study identified stem loop binding protein (SLBP) as a host protein that interacts with -1 PRF RNA, promoting #SARSCoV2 #Frameshifting and replication, highlighting SLBP as a potential #DruggableTarget for #COVID19. #medsky

#STTT #OpenAccess: doi.org/10.1038/s413...

This study shows that SLBP directly binds #SARSCoV2 -1 PRF RNA, enhancing #frameshifting and viral replication, as verified by RNA pull-down, EMSA, and smFISH, highlighting SLBP as a potential drug target for #COVID19. #medsky

Read in #STTT #OpenAccess: doi.org/10.1038/s413...