🩸 Questions of the day!

🧬 The first question explores #germline marrow failure syndromes, including #GATA2 mutations and inherited #MDS risk.

🔎 The second question looks at VEXAS syndrome in the context of marrow failure.

Swipe for answers and explanations!

#Hematology #BoneMarrowFailure #IBMFS

#RecercaUB |Alessandra Giorgetti, #PDI de la UB, lidera recerques sobre #leucèmia que impulsen el coneixement sobre el procés molecular pel qual les cèl·lules mare hematopoètiques esdevenen canceroses.
La #recerca surt a #Leukemia i #NatureCommunications.

🖱️ bit.ly/48xjJ3u

#càncer #GATA2 #IDIBELL

Online now! Hematopoietic #stemcell defects in #Gata2 haploinsufficiency driven by impaired DNA damage response and inflammatory signaling; disrupting self-renewal, differentiation, and genomic stability ow.ly/28kC50WygLf

@cardiffuni.bsky.social @isscr.org

#GATA2 Deficiency With Early-Onset and Progressive Interstitial Lung Disease
onlinelibrary.wiley.com/doi/10.1002/...
#ILD

Provisional results at @ash-hematology.bsky.social from the the NCI clinical trial using RIC #HCT with briquilimab (anti CD117) for patients with #GATA2. #BMFsm @sung-yun-pai.bsky.social Dani Arnold #ASH24

🎬Have you read our paper on how mitotic bookmarking influences #hematopoiesis as #GATA2 clings to chromatin during cell division? If not, watch this 1-min #video by the talented Studio Kimchi. #ScienceCommunication @SpringerNature @NatureComms
Paper link:

2/12 💡We focus on three hematopoietic factors: GATA2, GFI1B, and FOS that are sufficient to initiate homogenesis. While GATA2 retains binding to #chromatin throughout mitosis, GFI1B and FOS do not. How does #GATA2 maintain its attachment to DNA during cell division?

Paper accepted! Outcome of 5 years of work of @ritalves94 at @lunduniversity. It feels even better to receive the decision in this scenery! Look for it in the coming weeks! /FP #hematopoiesis #mitotic #bookmarking #GATA2