Epigenetics Update - Three-dimensional genome reorganization foreshadows zygotic genome activation in Drosophila go.nature.com/3Mql3NG

Juan M. Vaquerizas (Imperial College London) reporting in Nat Genet

#Epigenetics #GenomeOrganization
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Hi-res insights without cell sorting; epigenometech.com

Check out our workshop on mechanisms by which 1D and 3D processes are integrated in the genome: pks.mpg.de/neg26. I am organizing this with Buddhapriya Chakrabarti, Srinjan Basu and Angelo Rosa. #epigenetics #genomics #physics #chromatin #genomeorganization

How HIV enters the genome – Researchers identify previously unknown mechanism | German Center for Infection Research Researchers at the German Center for Infection Research (DZIF) at Heidelberg University Hospital have decoded a previously unknown mechanism by which

www.dzif.de/en/how-hiv-e...
@dzif.bsky.social @dfg.de @natmicrobiol.nature.com #HIV #HIVScience #HIVCure #Nucleus #Nucleararchitecture #Splicing #R-loops #Genomeorganization

Emerging roles for the nucleolus in development and stem cells Summary: This Review explores roles of the nucleolus in mammalian development, with a particular focus on genome organisation and chromatin regulation.

Nice review about alternative roles of nucleolus in genome organization in stem cells

Emerging roles for the nucleolus in development and stem cells | Development

#Review #Heterochromatin #GenomeOrganization #StemCells

journals.biologists.com/dev/article/...

Epigenetics Update - Native nucleosomes intrinsically encode genome organization principles go.nature.com/4iUj7qC

Taekjip Ha reporting in Nature

#Epigenetics #GenomeOrganization
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Gain deeper insights into gene regulation with epigenometech.com

#Nucleus #GenomeOrganization #CellBiology #MolecularBiology #Genetics #Genomics #LifeSciences

Epigenetics Update - Cell type-specific 3D-genome organization and transcription regulation in the brain bit.ly/3QBrkV3

Xiaowei Zhuang (Harvard) reporting in Science Advances

#Epigenetics #GenomeOrganization

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Gain deeper insights into gene regulation with epigenome.us

Source: https://www.biorxiv.org/content/10.1101/2024.11.27.625786v1.full Figure 1. GO-CaT is an efficient method for profiling genome-wide LAD structure (A) A working scheme of GO-CaT workflow. (B) Genome tracks comparing LaminB interaction profiles captured by LaminB DamID, GO-CaRT and GO-CaT in HEK293T cells at a representative region (chr1:63,888,968-109,339,020). (C) Correlation heatmap showing the Jaccard similarity of between LADs identified by LaminB1 DamID, GO-CaRT and GO-CaT in HEK293T cells. (D) Percentage of sequenced reads in LADs identified by DamID (orange), GO-CaRT (dark blue) and GO-CaT (light blue) in HEK293T. All experiments were sub-sampled to have equivalent number of reads and sequencing depth for comparison. (E) Metaplot showing normalized LaminB1 enrichment across all 0.5Mb flanking regions of the boundaries that distinguish LADs from inter-LAD in HEK293T.

Genome Organization with CUT and Tag (GO-CaT) identifies substructure and maturation of lamina-associated domains in neurons of the developing human brain. #GenomeOrganization #CutAndTag #LaminaDomains @biorxivpreprint.bsky.social 🧬
www.biorxiv.org/content/10.1...