Not sure what I'd do with the nickel, but I need those raspberries.

#gnomad #indiegame #gnomes

Check out our Gnomad Speedpaint!

Wishlist now on Steam!
steam.jollyware.studio/bsky

Join our community on Discord!
discord.jollyware.studio

#gnomad #speedpaint

Datasets from #gnomAD and #AllofUs are exponentially larger than previous resources. Leveraging these datasets is poised to significantly decrease the number of #VUS reported in highly penetrant, pediatric-onset diseases. #RareDisease #PrecisionMedicine bit.ly/3X4N9zu

Creating more scrungly little guys for our hand-drawn indie gnome game #Gnomad

Stay tuned for wizards, frogs, and mushrooms on logs

#indiedev #indiegame #devlog

I animated a gnome for our gnome themed indie game about bouncing ball combat.

Stay tuned for more gnomes, mushrooms, and wizards.

Have a #Gnomad day

#indiedev #devlog #indieanimation #screenshotsaturday

It's either point or be pointed at down here in The Sink Hole. Are you gonna be a pointer or a pointee?

It's day 4 of marathoning animations for or indie game #Gnomad

Stay tuned for more

#indiedev #gamedev #indiegame #wholesomegames #indieanimation #animation

Creating the dream Sodie Pop Rotation. Would you share a bottle with him?

The Sink Hole is home to lots of unsavory NPCs, and each one needs animation.

Follow for regular updates on the animations and world of #Gnomad.

#indiedev #gamedev #indiegame #wholesomegames

Furnishing the hand-drawn world of #Gnomad with thousands of sprite assets can really take it out of you. That's why we built a custom environment editor tool in @Unity.com that helps us manage thousands of sprites in every room. #indiedev #indiegame #WholesomeGames #gamedev #GamedevShowcase

Furnishing the hand-drawn world of #Gnomad with thousands of sprite assets can really take it out of you. That's why we built a custom environment editor tool in @Unity.com that helps us manage thousands of sprites in every room. #indiedev #indiegame #WholesomeGames #gamedev #GamedevShowcase

Furnishing the hand-drawn world of #Gnomad with thousands of sprite assets can really take it out of you. That's why we built a custom environment editor tool in @Unity.com that helps us manage thousands of sprites in every room. #indiedev #indiegame #WholesomeGames #gamedev #GamedevShowcase

Furnishing the hand-drawn world of #Gnomad with thousands of sprite assets can really take it out of you.

That's why we built a custom environment editor tool in @Unity.com that helps us manage thousands of sprites in every room.

#indiedev #indiegame #WholesomeGames #gamedev #GamedevShowcase

Working on animations in OpenToonz for our hand-drawn game #Gnomad

#gamedev #indiedev #indieanimation #indiegame

Just make it exist first. You can make it good later.

Join our Discord and watch #Gnomad become even gooder!

#gamedev #indiedev #indiegame #gnome

Has computer science gone too far?? How do you feel about these aesthetic changes?

We've been hard at work adding squishy squashy moss (yum), swaying bushes, and 100% all natural bumpable grass to the world of #Gnomad

#gamedev #indiedev #indiegame #gnome #gnomecore

Are we cooking with this one?

Gnomad's bouncing-ball-combat lets players fight and platform at the same time.

Let us know what you think? We're always looking for new ideas.

#indiedev #indiegame #gamedev #gnomecore #Gnomad

Grab, bounce, throw, and spike your foes in Gnomad, and hand drawn game featuring bouncing ball combat.

Follow for regular gameplay updates, and join our Discord to read our devlogs and join the Gnomad Community!

#indiedev #gamedev #indiegame #Gnomad

Peek into the world of Gnomad. Gander at the full range of assets: everything from clean sketches, to rough sketches, to really rough sketches. It's all part of the process.

Follow for more regular updates, and join our Discord!

#devlog #indiedev #indiegame #Gnomad

For #Gnomad, we like to alternate between small environmental puzzles and bouncing combat encounters, which creates a rhythm that keeps the flow of gameplay feeling fresh from room to room.

These are a few of the small puzzle segments we've been workshopping.

#IndieGames #IndieDevs

Analyzing genes constrained for LoF/Ms, Ms, and LoF variants in #gnomAD reveals their unique functional associations and links to #Mendelian disorders #HGMD #ClinVar bit.ly/43awIFE

Visiting the Broad Institute near Boston to attend #GA4GHConnect and meet with Heidi Rehm, #gnomAD team and Hail team ! That's an honor to be here.

#GA4GH #Genomics

Screenshot of Figure 1: The number of autosomal recessive genes that have GCF ≥ 0.5% for each genetic ancestry group. AFR, African/African American; AMR, Admixed American; ASJ, Ashkenazi Jewish; EAS, East Asian; FIN, Finnish; MID, Middle Eastern; NFE, European (non-Finnish); SAS, South Asian.

Variety is the spice of life! Study using #gnomAD v4.0 shows the variability of gene carrier frequencies across ancestry groups, which may help guide the development of more informative #carrierscreening panels bit.ly/4gKws4t #atriskcouples #geneticancestry

I'm so glad the #GnomAD team is on Bluesky! The PEXT measure is very useful for filtering disease variants to those which are highly expressed in tissues of interest. For anyone wishing to apply this measure, I'll point you to the original paper: www.nature.com/articles/s41...
🖥️🧬

When I can find #gnomAD updates here, I know I am at the right place for #genetics

Proportion expressed across transcripts (pext), using GTEx v10, is now available on #gnomAD v4!

GeniE, the genetic prevalence estimator, is now available! broad.io/genie

This tool allows users to estimate the genetic prevalence of autosomal recessive diseases using #gnomAD allele frequency data & classifications from #ClinVar

Blog post: broad.io/genie_blog

gnomAD 4.1 is now live! This release fixes the AN issue in #gnomAD v4.0 & adds 2 new functionalities:
1) Joint AN across all called sites in exomes and genomes
2) A flag indicating when exomes and genomes frequencies are highly discordant

Learn more at broad.io/gnomad_v4-1

The #gnomAD v3 papers are now published! This includes the non-coding constraint paper broad.io/gnomAD_v3_non_coding & inferring compound heterozygosity paper broad.io/gnomAD_v3_comp_het Congratulations to everyone who contributed to this valuable work! (1/2)

gnomAD A place for users of the Genome Aggregation Database to discuss the data, ask questions, and get help from eachother and the gnomAD team.

As part of v4, we are happy to announce the launch of the #gnomAD forum broad.io/gnomad_forum. This will be a place for our users to help each other, discuss the data and ask questions. #ASHG2023

Gene constraint is now available on #gnomAD v4! This is the first time we have had constraint data available on GRCh38. Katherine Chao will be covering this work during her talk at #ASHG23 tomorrow (11/4) at 11am in rm 202A.

As part of #gnomAD v4, in collaboration with the Talkowski Lab, we have released 1,199,117 genome SVs and 66,903 rare exome CNVs. These data represent the first gnomAD SV dataset released native to the GRCh38 reference genome. (1/2)

I can't image a be a better first post on bluesky! I am so excited to have #gnomAD v4 finally launched. An open-source dataset of this scale is going make a difference for patients and families with rare disease #genechat

If you are attending #ASHG23 please stop by the @BroadInstitute Clinical Lab booth (#938) during our #gnomAD office hours to meet the team, ask questions, and learn more about v4. (5/11)

11/2 & 11/3: 10-10:45am, 3-5pm
11/4: 10-10:45am, 2:15-4:15pm

 #ASHG2023

Our genetic ancestry blog broad.io/gnomad_ancestry discusses our efforts to improve representation in #gnomAD, how we label groups and how the diversity in gnomAD is improving genomic filtration. (4/11)