A mid-stage egg chamber taken from a PSR+ female, when hybridized with a PSR probe cognate to the haploidizer gene, reveals the presence of PSR (red) in the polyploid nurse cell nuclei (NCN), the oocyte nucleus (ON) (B′), and somatic follicle cells (FCs) (B″). rDNA is shown in blue, and DNA is gray. Scale bar equals 15 μM. (B′) and (B″) are shown in higher magnification. The white arrow in (B′) indicates the single copy of PSR in the chromatin body of the germinal vesicle.

Selfish B chromosomes can spread via super- #Mendelian transmission, but this can be limited by forces like drag. This study shows that jewel #wasp PSR #chromosome spreads via strong paternal drive, hidden female meiotic drag, and restriction to a single copy @plosbiology.org 🧪 plos.io/4r0cJCE

A mid-stage egg chamber taken from a PSR+ female, when hybridized with a PSR probe cognate to the haploidizer gene, reveals the presence of PSR (red) in the polyploid nurse cell nuclei (NCN), the oocyte nucleus (ON) (B′), and somatic follicle cells (FCs) (B″). rDNA is shown in blue, and DNA is gray. Scale bar equals 15 μM. (B′) and (B″) are shown in higher magnification. The white arrow in (B′) indicates the single copy of PSR in the chromatin body of the germinal vesicle.

Selfish B chromosomes can spread via super- #Mendelian transmission, but this can be limited by forces like drag. This study shows that jewel #wasp PSR #chromosome spreads via strong paternal drive, hidden female meiotic drag, and restriction to a single copy @plosbiology.org 🧪 plos.io/4r0cJCE

A mid-stage egg chamber taken from a PSR+ female, when hybridized with a PSR probe cognate to the haploidizer gene, reveals the presence of PSR (red) in the polyploid nurse cell nuclei (NCN), the oocyte nucleus (ON) (B′), and somatic follicle cells (FCs) (B″). rDNA is shown in blue, and DNA is gray. Scale bar equals 15 μM. (B′) and (B″) are shown in higher magnification. The white arrow in (B′) indicates the single copy of PSR in the chromatin body of the germinal vesicle.

Selfish B chromosomes can spread via super- #Mendelian transmission, but this can be limited by forces like drag. This study shows that jewel #wasp PSR #chromosome spreads via strong paternal drive, hidden female meiotic drag, and restriction to a single copy @plosbiology.org 🧪 plos.io/4r0cJCE

Understanding Vascular Toxicity of Indigo Naturalis in Anti-Inflammatory Applications: Mendelian Randomization and Co-localization Study Announcing a new article publication for BIO Integration journal. Indigo naturalis (IN), a traditional Chinese herbal medicine, shows promising potential for treating autoimmune inflammatory diseases....

#Mendelian randomization reveals vascular risks of #indigonaturalis, identifying deep vein #thrombosis and urate-mediated effects relevant to its #clinicalsafety.

#OpenAccess: bio-integration.org/vascular-tox...

Genotype-first approaches in genomic research enable a deeper, less biased understanding of #Mendelian diseases, improving assessment of their penetrance and presentation. bit.ly/45vtLAh #Genomics #AllofUS #PrecisionMedicine

New finding from TWright_GenomeX on Twitter/X! ift.tt/H9ZubE6

@Ddysmo @alkuraya @mft_iMRare @EpiGenRare @EdinburghUni @PolicyLabCHOP Next up Day 2 Session C #MDC25

@POLICYLabCHOP Dr Elizabeth Bhoj characterised

🧬 Novel #Mendelian #neurodeve…

#Mendelian Randomization Analysis of the Causal Link Between #RheumatoidArthritis and #InterstitialLungDisease
onlinelibrary.wiley.com/doi/10.1002/...

Researchers show benefit of ultra-deep RNA sequencing in Mendelian disorder diagnostics RNA sequencing (RNA-seq) is a powerful tool in diagnosing Mendelian disorders, but the optimized sequencing depth for this technology has not yet been...

Researchers show benefit of ultra-deep #RNA sequencing in #Mendelian disorder #diagnostics. PF Liu et al @bcmhouston.bsky.social @bcmgenetics.bsky.social @ajhgnews.bsky.social www.bcm.edu/news/researc...

The role of untranslated region variants in Mendelian disease: a review - European Journal of Human Genetics European Journal of Human Genetics - The role of untranslated region variants in Mendelian disease: a review

Not all pathogenic variants are in coding regions! 👀
📢 This review highlights Mendelian disease-causing UTR variants, their mechanisms, and implications for clinical interpretation. 🧬 #Mendelian #UTRvariants #ejhg

www.nature.com/articles/s41...

💭 How do we move from response to prevention in #SCA? Read this new #editorial on SCA, #Mendelian randomization, and modifiable lifestyle factors! Learn more about causal clues and caveats from Mendelian randomization studies ⬇️
onlinecjc.ca/article/S082...
#CJC

Causeway is a flexible and scalable pipeline for integrating #GWAS and QTL data to prioritize causal genes using #Mendelian Randomization and colocalization.

Analyzing genes constrained for LoF/Ms, Ms, and LoF variants in #gnomAD reveals their unique functional associations and links to #Mendelian disorders #HGMD #ClinVar bit.ly/43awIFE

This study identifies CCND2 and KLF4 as core genes implicated in keloid development through integrated #bioinformatics and #Mendelian randomization analysis. It also explores immune cell infiltration and assesses the broader impact of these genes across multiple cancer types.

HORNET is a comprehensive toolset for genome-wide causal gene discovery using multivariable #Mendelian randomization and #eQTL summary statistics. It corrects for confounding, LD bias, and missing data to enable robust identification of gene-trait associations across tissues.

🧬He had #ALS But why?🔍 SScientists dug deep—#Proteomics+ #Mendelian magic!
📈High #SHBG ⚠️Low #Testosterone=higher #Risk💥
💡Could #Hormones be the next big #Breakthrough? Biomedi cines @mdpiopenaccess.bsky.social
#ALS #Genetics #Neuroscience
🧠Dive in → www.mdpi.com/2227-9059/13...

🔬 Exploring Causation in Epidemiology! 🔬

As part of the Institute of Applied Health Sciences Methodological Innovation Group seminar series, Dr Marcus Beasley led a fantastic session on #Mendelian #Randomisation - a powerful tool for strengthening #causal inference in epidemiology 🧬📊

Could the exclusion restriction be plausibly true when the exposure is a loneliness score from a questionnaire, the instrument is genetic and the outcome is biochemical? It seems to ask a lot from the questionnaire.
#instrumental #mendelian

5/19 With Vavilov ousted, modern genetics, even the concept of a gene, #Mendelian inheritance and evolution also became symbols of an unwanted reactionary movement, and the Marxist-Leninist Lysenkoism took their place as ruling principle.

New study identifies key protein biomarkers for early detection of pancreatic cancer Study used a Mendelian randomization approach to identify REG1A and REG1B as potential biomarkers for early detection of pancreatic cancer, showing their causal effects and significance in cancer scre...

New study identifies key protein biomarkers for early detection of pancreatic cancer 🔬🧬🔍 www.news-medical.net/news/2024051... #PancreaticCance #CancerResearch #Biomarkers #ProteinBiomarkers #Mendelian #CancerScreening #REG1A #REG1B