We were thrilled by the turnout for our webinar!
A special thank you to the Miller Lab for sharing their research on how #HCRtechnology can visualize gene expression in the developing kidney and study how genetic variants disrupt nephron development.
Watch the replay here: tinyurl.com/54eyp4ed
Tune in on April 1 at 8:00 AM PT / 10:00 AM CT for a preview of never-before-shared images, and see how #HCRtechnology helps the Miller Lab investigate genes linked to CAKUT and better understand the mechanisms driving congenital kidney disease.
Register here: my.demio.com/ref/2ZwGxz9P...
A study from Jimenez et al. brings high-res molecular readouts to Paroedura picta.
Using #HCRtechnology, the team mapped gene expression in the embryonic gecko brain, enabling clear mRNA visualization in a system with limited species-specific antibody options.
Read more: tinyurl.com/5dnwkm3h
#onlywithHCR: LaBelle et al. reveal that cell–cell collisions are drivers of the dispersal of endodermal cells in zebrafish embryos. With #HCRtechnology, they observed epha2a expression, finding that endodermal cells undergo RhoA-dependent, active repulsion-type CIL.
Read more: tinyurl.com/mrx934sc
#onlywithHCR: Diaz Soria et al. used scRNA-seq with #HCRtechnology to build a cellular atlas of the mother sporocyst, spatially validating 6 major cell types and revealing key regulators of early parasite growth and snail-host interaction.
Read the full study @nature.com: tinyurl.com/bp7dbsjx
#onlywithHCR: Gillis et al. used #HCRtechnology to visualize gene expression during gill slit formation in skate embryos, revealing a precise sequence of epithelial interactions between the endoderm and ectoderm.
🔬 Read more: tinyurl.com/3mvj2wu2
#onlywithHCR: Bhandiwad et al. utilized #HCRtechnology to map the neural activity underlying tonic immobility. They found that this outlines a complete sensorimotor circuit, revealing how the brainstem circuit suppresses movement when facing threats.
Read more: tinyurl.com/4dcxhs38
#onlywithHCR: Sun et al. uncovered a crucial role for Zic5 in Xenopus eye development. Using #HCRtechnology, they showed Zic5 expression in the RPE and NR at the optic vesicle stage, where it helps tune Hedgehog signaling to ensure proper eye development.
Read more: tinyurl.com/mrxru323
#onlywithHCR: Busby et al. utilized #HCRtechnology to track gene expression during chicken somitogenesis. They revealed a stalled cell state linked to Hox genes, indicating that developmental timing is set intrinsically but can also be influenced by extrinsic cues.
Read more: tinyurl.com/pxs5jrcu
#onlywithHCR: Janesick et al. created an RNA-seq atlas of the chicken cochlea, revealing regenerative insights. Using #HCRtechnology to validate gene expression, they found tonotopic gradients along the cochlea, setting up the stage for comparative studies.
Read more: tinyurl.com/2t7zhfwn
#onlywithHCR: With #HCRtechnology, Witch et al. revealed that salamander brain comparisons point to the DVR and neocortex evolving through convergence, while the mammalian olfactory-entorhinal-hippocampal circuit may trace back to ancestral origins.
Read more: tinyurl.com/4bwm599u
#onlywithHCR: Treen et al. pinpointed two Prdm1 homologs as the earliest FGF-responsive genes. By combining #HCRtechnology with genetic and experimental manipulations, they found a sharp developmental transition between the 8- and 16-cell stages.
Read more: genesdev.cshlp.org/content/37/3...
#onlywithHCR: Kim et al. dissected how human pyramidal neurons connect to inhibitory interneurons in a cell type-specific manner. Using #HCRtechnology to confirm cell types and gene expression, they discovered conserved synaptic motifs in human brain circuits.
Read more: tinyurl.com/4nrsm275
#onlywithHCR: Lin et al. mapped ~500K nuclei across 19 CNS regions in marmoset to chart glial diversity.
With #HCRtechnology, they visualized key gene expression patterns in OLIG2+ cells, revealing transcriptional shifts in white matter glia within a 3D context.
Read more: tinyurl.com/bdfadjnr
Join us for a Lunch & Learn at the Harvard Center for Biological Imaging! This session will feature a talk by Dr. Aneesh Acharya, who will share new and exciting updates on #HCRtechnology.
📍 16 Divinity Ave, BioLabs RM1080
🗓️ July 22nd, 2025 at 12:00 PM
