Great to see this ALS research move from preprint to publication. The newly published work from Fiskum et al. In ๐ก๐ฒ๐๐๐ผ๐ฟ๐ธ ๐ก๐ฒ๐๐ฟ๐ผ๐๐ฐ๐ถ๐ฒ๐ป๐ฐ๐ฒ offers powerful new insight into how motor neurons are affected in ALS.
Congratulations to ๐ฉ๐ฒ๐ด๐ฎ๐ฟ๐ฑ ๐๐ถ๐๐ธ๐๐บ and the ๐๐ผ๐ฎ๐ป๐ป๐ฎ ๐ฆ๐ฎ๐ป๐ฑ๐๐ถ๐ด lab!
#ALS #HDMEA #iPSC
New organoid research shows SMA affects far more than motor neurons, revealing widespread CNS disruptions. Using CorePlateโข HD MEAs, researchers found reduced activity, glutamate hyperexcitability, and showed early ASO treatment can rescue function. Huge thanks to the team! #iPSC #HDMEA #3Brain
๐๐ผ๐ ๐ฑ๐ผ๐ฒ๐ ๐๐ต๐ฒ ๐ฏ๐ฟ๐ฎ๐ถ๐ป ๐ฏ๐ฎ๐น๐ฎ๐ป๐ฐ๐ฒ ๐ฒ๐
๐ฐ๐ถ๐๐ฎ๐๐ถ๐ผ๐ป & ๐ถ๐ป๐ต๐ถ๐ฏ๐ถ๐๐ถ๐ผ๐ป?
A new study by ๐๐ฟ๐ผ๐ฐ๐ฐ๐ผ et al. (๐๐ฟ๐ฒ๐บ๐ถ๐๐ถ ๐๐ฎ๐ฏ) uses stem cell-derived DT/VT populations on CorePlateโข to map how E/I ratios shape network dynamics. Vital research for understanding neurodevelopmental disorders.
#3Brain #HDMEA #electrophysiology
๐๐น๐ผ๐ฐ๐ธ et al. from the ๐๐ฟ๐ฒ๐๐ฐ๐ต๐ป๐ฒ๐ฟ ๐น๐ฎ๐ฏ utilised CorePlateโข HD-MEAs to show avian retinas feature saltatory conduction. Tracking spikes propagation along the axons, they found spikes can travel 4x faster than in rodents!
#Neuroscience #Electrophysiology #HDMEA #Retina
๐๐ผ๐ฟ๐ฏ๐ฒ๐ฟ๐ด๐ฒ๐ฟ, ๐๐ฟ๐ฎ๐ด๐ฒ๐น๐๐ป๐ฑ & ๐๐ต๐ฒ ๐๐ถ๐ฟ๐๐ฐ๐ต๐๐๐ฒ๐ถ๐ป lab have developed a protocol which shows how to use CorePlateโข enabled 3D HD-MEAs (4,096 electrodes) to map how tumors disrupt brain networks. By tracking activity trajectories (CATs), they revealed lost functional connectivity in glioma models. #HDMEA #Cancer
WORD 2026 - This year, we presented a scientific poster on CorePlateโข recordings of hippocampal organoids and their responses to various neuroactive compounds. A huge thankโyou to everyone who visited our booth, discussed their work, and shared new ideas!
#WORD2026 #BrainOrganoids #HDMEA #Ephys
How do we better model cholinergic pathways? By building human brain assembloids. Using CorePlateโข 3D electrodes, the ๐๐ถ๐ ๐๐ฎ๐ฏ recorded high-res data from hnbM-cortical projections, even transplanting them into mice to establish human-derived pathways. #3Brain #iPSC #HDMEA #Organoids #Assembloids
๐ญ๐ฎ๐ฝ๐ณ๐ฒ et al. used CorePlateโข to track the center of mass of current in the hippocampus. Itโs not just data, itโs a way to see hidden synaptic interactions in high-res. As a bonus, the current source density (CSD) graphics are stunning!
#Electrophysiology #HDMEA #Hippocampus #NeuralCircuits
How DNMT3A mutations reshape neural circuits. New work shows TBRS-associated DNMT3A mutations disrupt human cortical interneuron development, driving GABAergic hyperactivity and abnormal network bursting, revealed using CorePlateโข enabled HD-MEAs.
#Neuroscience #3Brain #Electrophysiology #HDMEA
๐กExciting NEUREKA Project news from Vassanelli & Poirazi Labs: A new IC method on HD-MEAs shows we can predict neuronal network causal architecture using spontaneous activity.
www.biorxiv.org/content/10.1...
#Neuroscience #HDMEA #NeuronalNetworks #FunctionalConnectivity
