We're at the Membrane Physiology Symposium 2026 in Napa Valley! Meet ๐๐บ๐ฏ๐ฒ๐ฟ ๐๐ผ๐น๐น๐ at the Meritage Resort & Spa to see how CorePlateโข HD-MEA platforms deliver high-resolution, label-free functional insights for neuronal and cardiac research.
#3Brain #MembranePhysiology #IonChannels #Electrophysiology
How do cortical and hippocampal neurons differ in their baseline firing and drug response? Our latest application note uses ๐๐ผ๐ฟ๐ฒ๐ฃ๐น๐ฎ๐๐ฒโข ๐ฒ๐ช and ๐๐๐ฝ๐ฒ๐ฟ๐๐๐ ๐๐น๐ฝ๐ต๐ฎ to functionally screen both side by side with ๐๐๐ฐ๐น๐ผ๐๐ต๐ถ๐ฎ๐๐ถ๐ฑ๐ฒ (๐๐ง๐ญ). Check it out: resources.3brain.com/f1/downloads...
#HDMEA #Electrophysiology
Great to see this ALS research move from preprint to publication. The newly published work from Fiskum et al. In ๐ก๐ฒ๐๐๐ผ๐ฟ๐ธ ๐ก๐ฒ๐๐ฟ๐ผ๐๐ฐ๐ถ๐ฒ๐ป๐ฐ๐ฒ offers powerful new insight into how motor neurons are affected in ALS.
Congratulations to ๐ฉ๐ฒ๐ด๐ฎ๐ฟ๐ฑ ๐๐ถ๐๐ธ๐๐บ and the ๐๐ผ๐ฎ๐ป๐ป๐ฎ ๐ฆ๐ฎ๐ป๐ฑ๐๐ถ๐ด lab!
#ALS #HDMEA #iPSC
We're Heading to the French Alps for the ๐ต๐๐ต ๐๐ฒ๐ฟ๐ฒ๐ฏ๐ฒ๐น๐น๐๐บ ๐๐ฎ๐๐ to join world-leading researchers at the CNRS Paul Langevin Center in ๐๐๐๐๐ผ๐ถ๐ from ๐ ๐ฎ๐ฟ๐ฐ๐ต ๐ฎ๐ฒ๐๐ต โ ๐ฎ๐ต๐๐ต. If youโre interested in exploring the functional activity of your cerebellar slices, be sure to connect with us.
#3Brain #Cerebellum
Visit 3Brain (Mar 22โ25, San Diego) to see how our CorePlateโข HD-MEA platforms turn organoids and spheroids into actionable data. Accelerate your neuro/cardiotoxiology research with functional insights from our BioCAM and HyperCAM Delta.
#2026SOT #ToxExpo #3Brain
New organoid research shows SMA affects far more than motor neurons, revealing widespread CNS disruptions. Using CorePlateโข HD MEAs, researchers found reduced activity, glutamate hyperexcitability, and showed early ASO treatment can rescue function. Huge thanks to the team! #iPSC #HDMEA #3Brain
Celebrating our 2025 MGA winner, Noelia Antรณn Bolaรฑos! Her work pushes functional neuroscience forward and holds real potential for human health. Read her project story and interview here (onlylinks.cc/OevP) and stay tuned for 2026 MGA applications!
Check it out here: www.cell.com/stem-cell-re...
๐๐ผ๐ ๐ฑ๐ผ๐ฒ๐ ๐๐ต๐ฒ ๐ฏ๐ฟ๐ฎ๐ถ๐ป ๐ฏ๐ฎ๐น๐ฎ๐ป๐ฐ๐ฒ ๐ฒ๐
๐ฐ๐ถ๐๐ฎ๐๐ถ๐ผ๐ป & ๐ถ๐ป๐ต๐ถ๐ฏ๐ถ๐๐ถ๐ผ๐ป?
A new study by ๐๐ฟ๐ผ๐ฐ๐ฐ๐ผ et al. (๐๐ฟ๐ฒ๐บ๐ถ๐๐ถ ๐๐ฎ๐ฏ) uses stem cell-derived DT/VT populations on CorePlateโข to map how E/I ratios shape network dynamics. Vital research for understanding neurodevelopmental disorders.
#3Brain #HDMEA #electrophysiology
Excited to join pharma & biotech leaders at ENIF. At 3Brain, weโre pushing HDโMEA innovation, from the first commercially available HDโMEA, to CorePlateโข 3D & our new 96โwell platform. Partnering with pharma drives our breakthroughs. If youโre at ENIF, come say hi and talk HDโMEA innovation.
Join our Lunch & Learn on 3Brain's CorePlateโข HD-MEAs: network activity with single-cell precision in neuronal and cardiac cultures. Explore maturation, disease models, and compound effects. Single-well to 96-well plus CorePlateโข 3D for organoids. Tues, Mar 3, 12-1 PM, Gladstone. Lunch provided.
๐๐น๐ผ๐ฐ๐ธ et al. from the ๐๐ฟ๐ฒ๐๐ฐ๐ต๐ป๐ฒ๐ฟ ๐น๐ฎ๐ฏ utilised CorePlateโข HD-MEAs to show avian retinas feature saltatory conduction. Tracking spikes propagation along the axons, they found spikes can travel 4x faster than in rodents!
#Neuroscience #Electrophysiology #HDMEA #Retina
New research from the ๐๐ผ๐น๐น๐ถ๐๐ฐ๐ต ๐๐ฎ๐ฏ uses computational modelling to predict RGCs responses across species with data collected from CorePlateโข enabled HD-MEAs. The findings: Divisive & Subtractive models beat feedback, Divisive = best for fast kinetics, Subtractive = best for slow signals.
#retina
๐๐ผ๐ฟ๐ฏ๐ฒ๐ฟ๐ด๐ฒ๐ฟ, ๐๐ฟ๐ฎ๐ด๐ฒ๐น๐๐ป๐ฑ & ๐๐ต๐ฒ ๐๐ถ๐ฟ๐๐ฐ๐ต๐๐๐ฒ๐ถ๐ป lab have developed a protocol which shows how to use CorePlateโข enabled 3D HD-MEAs (4,096 electrodes) to map how tumors disrupt brain networks. By tracking activity trajectories (CATs), they revealed lost functional connectivity in glioma models. #HDMEA #Cancer
WORD 2026 - This year, we presented a scientific poster on CorePlateโข recordings of hippocampal organoids and their responses to various neuroactive compounds. A huge thankโyou to everyone who visited our booth, discussed their work, and shared new ideas!
#WORD2026 #BrainOrganoids #HDMEA #Ephys
Meet us at the Science & Tech Expo on Feb 10 at the Alexandria Center, Stanford Research Park!
Discover how CorePlateโข HDโMEAs enable deeper functional insights across neuronal & cardiac models. Plus free desserts, coffee & smoothies. Come say hi!
New research from ๐๐ฎ๐ป๐ป๐ฒ๐น๐น๐ผ & ๐๐ถ๐ฎ๐บ๐ฝ๐ถ (๐๐บ๐ฎ๐๐ผ group) shows how cultured neurons can be used for Biological Reservoir Computing. By encoding images into electrical patterns via HD-MEAs, theyโve enabled biological networks to perform pattern recognition. Check out the paper here: arxiv.org/abs/2510.05637
Check out the paper here: www.cell.com/cell-stem-ce...
How do we better model cholinergic pathways? By building human brain assembloids. Using CorePlateโข 3D electrodes, the ๐๐ถ๐ ๐๐ฎ๐ฏ recorded high-res data from hnbM-cortical projections, even transplanting them into mice to establish human-derived pathways. #3Brain #iPSC #HDMEA #Organoids #Assembloids
๐ญ๐ฎ๐ฝ๐ณ๐ฒ et al. used CorePlateโข to track the center of mass of current in the hippocampus. Itโs not just data, itโs a way to see hidden synaptic interactions in high-res. As a bonus, the current source density (CSD) graphics are stunning!
#Electrophysiology #HDMEA #Hippocampus #NeuralCircuits
Check out the preprint here: www.biorxiv.org/content/10.1...
๐ ๐ถ๐ฐ๐ฟ๐ผ๐ด๐น๐ถ๐ฎ ๐ถ๐ป ๐๐ต๐ฒ ๐ฐ๐ถ๐ฟ๐ฐ๐๐ถ๐!
๐ช๐ et al. show that adding human microglia to organoids and assembloids shapes circuit formation and activity, and that CorePlateโข HD-MEAs enabled them to reveal functional midbrainโstriatal connectivity and hyperactivity in ASD-mutant assembloids.
