Join us for the Pharmacology Seminar Series as Dr. Elizabeth Woodruff discusses how chronic stress influences #HGSC progression and immune response through adrenergic signaling in the omentum. #OvarianCancer #GynOnc #CUAnschutz
Date 📅: Mon, 10/20/25, 12:00 PM MST
Location📍: RC1 North, Room 6107
6/6 Our findings suggest that lncRNAs could be promising biomarkers to guide PARPi therapy and support better treatment decisions in ovarian cancer.
There’s still much to test before this can move into the clinic, but the potential is exciting.
#OvarianCancer #HGSC #LncRNA #PARPi #Biomarker
5/6 Functionally, this lncRNA helps maintain genome stability by regulating DNA replication.
Loss of it speeds up replication, causing DNA damage + instability.
#OvarianCancer #HGSC #LncRNA #PARPi #Biomarker
4/6 Even better: it’s detectable in both tissue and plasma.
That means it could work as a minimally invasive blood-based biomarker for HRD, measurable with a simple RT-PCR test.
#OvarianCancer #HGSC #LncRNA #PARPi #Biomarker
3/6 The top hit: ENSG00000272172.1
Upregulated in HRD+ tumors Strongly correlated with HRD-score in TCGA + independent samples
Higher expression → better overall survival
#OvarianCancer #HGSC #LncRNA #PARPi #Biomarker
2/6 We asked: could long non-coding RNAs (lncRNAs) be predictive? We found in the TCGA data a panel of 29 lncRNAs linked to HRD status and drug sensitivity in HGSC tumors. #OvarianCancer #HGSC #LncRNA #PARPi #Biomarker
1/6 High-grade serous ovarian cancer (HGSC) is one of the deadliest cancers. PARP inhibitors (PARPi) help patients with homologous recombination deficiency (HRD), especially those with BRCA1/2 mutations, but current biomarkers are limited. #OvarianCancer #HGSC #LncRNA #PARPi #Biomarker
🎉Dr. Lindsay Brubaker is tackling therapy resistance in #HGSC with cutting-edge research on antibody-drug conjugates (ADCs). Backed by a competitive DOD grant, her study explores epigenetic drivers to expand and improve treatment options. View Article bit.ly/4fxHr1E #OvarianCancer #CUAnschutz
Big news! @chipubschools.bsky.social is the first school district in the country to earn Healthy Green Schools & Colleges Gold Certification. www.lawndalenews.com/2025/05/cps-...
#Sustainability #GreenSchools #CPS #HGSC #CPSProud
We’re celebrating a major achievement at CPS! 🏆Our district earned Gold Certification under the Healthy Green Schools & Colleges Standard, reflecting our deep commitment to creating healthier, greener schools for all: www.healthygreenschools.org/2025/05/cps-...
#GreenSchools #CPS #HGSC #CPSProud
Big news! Chicago Public Schools is the first school district in the country to earn Gold Certification from the Healthy Green Schools & Colleges program. Learn how we reached this major milestone: www.healthygreenschools.org/2025/05/cps-...
#Sustainability #GreenSchools #CPS #HGSC #CPSProud
High-grade serous carcinoma is a tough ovarian cancer to treat and often recurs after chemotherapy. Dr. Marjon recently resubmitted a paper showing that targeting certain tumor immune cells could help make treatments like chemotherapy more effective. Wishing her luck🤞 #HGSC #CUAnschutz #GynOnc
Momie Yamamoto and Ritz Iwanaga from Dr. Bitler's lab at CU Anschutz recently submitted a paper showing that Chromobox2 (CBX2) plays a role in driving HGSC progression. This suggests a potential new treatment option for HGSC patients. Wish them luck publishing their paper #HGSC #GynOnc #CUAnschutz
@afarkkila.bsky.social, Sara, Ada, and Aleksandra are representing the lab at ESSB in Berlin!
Find them to discuss spatial biology!
🟠 Poster #88: Ada presents a spatial study of the cell cycle in #HGSC
🟠 Poster #155: Aleksandra showcases the use of ML to uncover spatial tumor ecosystems
19/n Also, huge thanks to our funding agencies #ERC (projects SPACE and STRONGER), Sigrid Jusélius Foundation, Research Council of Finland, Cancer Foundation Finland, Foundation for the Finnish Cancer Institute, Instrufoundation. Let's continue fighting #HGSC together💪.
16/n In summary: our study sheds light on chemotherapy-induced myeloid-driven spatial T-cell exhaustion in #HGSC, opening new avenues for novel immunotherapeutic strategies to unleash CD8+ T-cell-mediated anti-tumor immunity.
15/n These results suggest that targeting the NECTIN2-TIGIT axis with ICB post-chemo, can reverse macrophage-driven CD8+ T cell exhaustion in #HGSC. Both TIGIT and NECTIN2 expression, even separately, predict functional response to anti-TIGIT therapy, making them strong biomarker candidates🎯.
5/n On the other hand, chemo reshapes the spatial landscape of #HGSC, transforming an spatially confined immunophenotype into a more infiltrated one. CD8+ T cells migrate from their “private” neighbourhoods toward cancer cell-hubs and #Myelonets.
2/n Spatial and molecular profiling of 117 #HGSC tumors pre- and post-chemo revealed a dynamic tumor ecosystem🔍. Using a high-plexed (30+🚨) antibody panel and #t-CycIF we identified #myelonets, interconnected networks of myeloid cells, as key drivers CD8+ T cell exhaustion upon chemotherapy.
1/n New paper alert 🚨 We're thrilled to share our just published paper in #CancerCell
Do you ever wonder how the #TME in #HGSC changes during chemotherapy? Check it here: www.sciencedirect.com/science/arti... and let’s dive into the highlights together #spatialbiology #ovariancancer #cancerresarch
A @humblegents.bsky.social classic on me Ed, with one of the best waterproof jackets I own,for a day on the beach 🏝️ 🤦♂️🤣🤣 #gill #navigator #hgsc
