SIRT5 enhances BMP9 osteo-inductive potential by stabilizing HIF-1α in mouse embryonic fibroblasts.
#SIRT5 #BMP9 #HIF1alpha #OsteogenicDifferentiation #BoneFormation #StemCellBiology
www.sciencedirect.com/science/arti...

Kupffer cell programming by maternal obesity triggers fatty liver disease - Nature In a mouse model, maternal obesity during pregnancy can lead to fatty liver disease in the offspring, driven by aberrant developmental programming of Kuppfer cells.

Maternal obesity alters function of offspring’s liver Kupffer cells leading to fatty liver disease.
Reprogramming during gestation requires #HIF1alpha.
Nice 👌. @masslab.bsky.social
I wonder how altered KC affects immunometabolism of other liver resident cells?
www.nature.com/articles/s41...