Han descifrado el TOC: ¿qué circuito impulsa la compulsión? Mapean la vía accumbens–hipotálamo–habénula que activa el “modo repetición” en ratones y aporta pistas clave para TOC y adicción en clínica. La noticia es clara y con nombres propios: un equipo del Ka...

Han descifrado el TOC: ¿qué circuito impulsa la compulsión? #Neurociencia #TOC #Adiccion #Cerebro #Karolinska #Ciencia #Conducta #Habenula #Hipotalamo #NucleoAccumbens #Optogenetica #SaludMental #Investigacion #27denoviembre #felizjueves
donporque.com/descifrado-e...

This data provides a foundation for future work into molecular changes that occur in the #Habenula in disease 🧠🧬 Keep an eye on @lieberinstitute.bsky.social for future work on the Hb spatially resolved transcriptomics with @10xgenomics.bsky.social tech #Visium and #Xenium 👀 #HabenulaLIBD

GitHub - LieberInstitute/Habenula_Pilot: habenulaPilot project code repository habenulaPilot project code repository. Contribute to LieberInstitute/Habenula_Pilot development by creating an account on GitHub.

Our #Habenula #singlecell and differential expression data is available to explore via our interactive websites 💻 #opendata github.com/LieberInstit...

We used #eQTL analysis to examine how SNPs relate to gene expression in #Habenula, 7 eQTLS genes were identified in differential expression, and 16 eSNPs were schizophrenia GWAS risk SNPs. Nine new schizophrenia colocalized genes with genetic risk were identified

We investigated whether the DEGs we found were unique to the #Habenula vs. other brain regions studied in schizophrenia (Caudate, Dentate Gyrus, dlPFC, Hippocampus) and found 75% of our DEGs were unique to habenula 🦄

We also profiled habenula-enriched tissue from schizophrenia and control donors using bulk RNA-seq #Transcriptomics, generating a unique dataset to identify disease associated molecular changes. PCA with bulk data from other regions shows #Habenula as an outlier

To provide cross-species context we integrated our human Hb snRNA-seq dataset with a previously published mouse #Habenula #singlecell dataset from @gstuber.bsky.social. Some neuronal subclusters such as human OPRM1-enriched LHb.2 appeared to be conserved across species 🐁

Transcriptomic Analysis of the Human Habenula in Schizophrenia | American Journal of Psychiatry Objective: The objective of this study was to define the molecular neuroanatomy of the human habenula (Hb) and identify transcriptomic differences between brains of individuals with schizophrenia and ...

Proud to announce our paper ‘Transcriptomic Analysis of the Human Habenula in Schizophrenia’ from @lieberinstitute.bsky.social is the cover article for the November issue of the American Journal of Psychiatry! 🧠 #HabenulaLIBD #snRNAseq #Habenula doi.org/10.1176/appi...

#Anhedonia - the inability to feel pleasure - is a core symptom of major depressive disorder and remains challenging to treat. The phase 2 #TERPSIS study evaluated NBI-1065846, a novel experimental #GPR139 #agonist targeting the #lateral #habenula.

🔗 Read more: journals.lww.com/psychopharma...

Habenula contributions to negative self-cognitions - Nature Communications Self-related cognitions are central to identity and wellbeing. Using 7-Tesla MRI, Kung et al map a dynamic network centred on the habenula demonstrating its role in encoding self-directed thinking and...

🚨 Out now in Nat. Commun!
Led by Po-Han (Terry) Kung & Trevor Steward (not @ Bluesky).
🔗 www.nature.com/articles/s41...
The habenula—a tiny midbrain hub—is implicated in restructuring negative self-beliefs.
#7TfMRI #Habenula #DCM @cgdavey.bsky.social @drkimfelm.bsky.social @alecjamieson.bsky.social

Ever wondered how #mitochondria are distributed in a #neuropil 🧠 ? Here's a beautiful #segmentation of the #habenula from a 5dpf #zebrafish! #Nuclei in pastel green, #mitochondria in blue. This volume is imaged using oxygen plasma #FIBSEM (Hydra G4 PFIB, Thermo Fisher).

A distinct hypothalamus–habenula circuit governs risk preference Nature Neuroscience - Groos et al. show that lateral habenula activity reflects individual risk preference before action selection. This activity is modulated by behavior-relevant synaptic input...

The #habenula in our brain tells us about the negative consequences of our actions, helping us avoid risky behaviors and problems with #addiction. My colleagues found neural pathways to the habenula that promoted consistency in the behavior of mice making risky or safe choices.

rdcu.be/d7g8d

Also would be interesting to study the stratification of nuclei within the volume. Could very well be the basic groundtruth of habenula nuclei subclusters. We shall see...
#habenula #zebrafish