#Haptoglobin

Robust Diagnostic and Therapeutic Biomarkers for Tuberculosis Identified Through Multi‐Omics and Mendelian Randomization Analysis We performed UPLC-MS/MS lipidomics and DIA proteomics on plasma from healthy controls, active TB patients, and cured patients, and used Mendelian randomization to prioritize diagnostic and cure bioma...

#Article in #MedComm
Robust Diagnostic and Therapeutic Biomarkers for Tuberculosis Identified Through #Multi_Omics and Mendelian Randomization Analysis doi.org/10.1002/mco2...

This article proposed #haptoglobin (HP) as a promising #biomarker and potential #TherapeuticTarget.

#LongCovid #Haptoglobin

Table showing endotypes of insulin-glucose homeostasis in patients with hidradenitis suppurative (HS or acne inversa) and different expressions of haptoglobin concentration. In persons with HS and a high haptoglobin concentration, insulin sensitivity (SPINA-GR) and beta-cell function (SPINA-GBeta) are similar but combine to provide a reduced disposition index (SPINA-DI).

Plot of SPINA-GBeta versus SPINA-GR in patients with HS and controls: The majority of patients with HS and diabetes are faced with rather low insulin sensitivity and a lack of dynamic compensation via pancreatic beta-cell function, resulting in a reduced disposition index.

#Hidradenitis suppurativa (acne inversa) is linked to #diabetes mellitus. In the affected, #SPINA-GR is reduced and not compensated by #SPINA-GBeta, resulting in low #SPINA-DI. This phenomenon may be mediated by #inflammation, as shown by ties to #haptoglobin.

pubmed.ncbi.nlm.nih.gov/40217596/