Development and Optimization of a Nanophytosomes‐Based Thermogel as a Topical Anti‐Psoriatic for Increased Solubility and Bioavailability Schematic illustration of the development, optimization, and therapeutic evaluation of the Leucas aspera phytosome-based thermogel for topical antipsoriatic therapy, highlighting its enhanced solubil...

#Review in #MedComm_Biomaterials_and_Applicaitons
Development and Optimization of a #Nanophytosomes‐Based #Thermogel as a Topical Anti‐#Psoriatic for Increased #Solubility and #Bioavailability doi.org/10.1002/mba2...
Authored by a team from #AdamasUniversity
#psoriasis #Zyclara #imiquimod #psoriasis

Colorectal Precancerous Lesions: Molecular Mechanisms, Research Tools, and Natural Product‐Based Clinical Translation This article systematically elucidates the molecular mechanisms of colorectal precancerous lesions, introduces cutting-edge research tools like multi-omics and organoids, and highlights the potential...

#Review in #MedComm_Oncology
Colorectal #Precancerous Lesions: Molecular Mechanisms, Research Tools, and Natural Product-Based Clinical Translation doi.org/10.1002/mog2...

#CRC #ColorectalCancer #MultiOmics #technologies #NaturalProducts

Oxidative Stress and DNA Epigenetic Modifications in Cancer: Mechanisms and Targeted Therapeutics Reactive oxygen species (ROS) modulate DNA methyltransferases (DNMTs), ten-eleven translocation family proteins (TETs) and their cofactors, reshaping 5-methylcytosine (5mC)/5-hydroxymethylcytosine (5....

#Review in #MedComm_Oncology
#Oxidative Stress and #DNA #Epigenetic Modifications in Cancer: Mechanisms and Targeted Therapeutics doi.org/10.1002/mog2...

The review provides a framework for developing ROS-guided #precision epigenetic #reprogramming strategies. #ROS

X‐Linked Inhibitor of Apoptosis Protein (XIAP) Contributes to ERK1/2‐Mediated Anoikis Resistance in Hepatocellular Carcinoma A schematic model of how XIAP contributes to ERK1/2-mediated anoikis resistance in HCC. The expression of XIAP is upregulated in HCC cells upon detachment, which contributes to their anoikis resistan...

#Article in #MedComm_Oncology
X-Linked Inhibitor of Apoptosis Protein (#XIAP) Contributes to #ERK1/2-Mediated #Anoikis Resistance in Hepatocellular Carcinoma (#HCC) doi.org/10.1002/mog2...

p-XIAP on Ser87 and the BIR 2/3 domains are necessary for anoikis resistance of HCC cell.

The JAK/STAT Pathway in Cancer: From Molecular Mechanisms to Clinical Applications Dysregulated JAK/STAT signaling and related genetic mutations are strongly associated with cancer progression, including promoting tumor proliferation, suppressing apoptosis, inducing immune suppress...

#Review in #MedComm_Oncology
The #JAK/#STAT Pathway in Cancer: From #Molecular Mechanisms to #Clinical Applications doi.org/10.1002/mog2...

By integrating the advance in the JAK/STAT pathway with cancer, the review underscores the potential for cancer therapy.
#SichuanUniversity

Stimuli‐Responsive Poly(Disulfide)s: A Versatile Platform for Intelligent Drug Delivery Systems Ring-opening polymerization based on dynamic disulfide bond exchange is an important method for synthesizing poly(disulfide)s. These polymers possess stimulus-responsive mechanisms and show broad pro....

#Review in #MedComm_Biomaterials_and_Applications
Stimuli‐Responsive Poly(#Disulfide)s: A Versatile Platform for Intelligent Drug Delivery Systems doi.org/10.1002/mba2...

#DrugDeliverySystem #DynamicCovalentBond #poly_disulfide #platform

#Highlight in @medcomm.bsky.social #MedComm

#OTOF Gene Therapy: From Breakthroughs to Roadmaps doi.org/10.1002/mco2...

The highlighted article in #NatureMedicine : doi.org/10.1038/s415...

#ClinicalTrials #GeneTherapy

#Letter in @medcomm.bsky.social #MedComm
#Clinical, #Prognostic, and #Biological Features of High-Risk Cardiometabolic Phenotype: The #REMODEL Study doi.org/10.1002/mco2...

Researchers from Duke NUS Medical School

Real‐Time MRI With Deep Learning for Efficient Evaluation of Neuromuscular Breathing Impairment Breathing impairment is an important and common symptom in neuromuscular disorders. Reliable diagnostics are highly warranted. Real-time MRI and deep learning-based lung segmentation were used to ana...

#Article in @medcomm.bsky.social #MedComm
#Real_Time #MRI With Deep Learning for Efficient Evaluation of #Neuromuscular Breathing Impairment doi.org/10.1002/mco2...

Researchers from University MedicalCenter Gottingen

#BreathingPattern #LOPD #Diaphragm #RespiratoryMuscleWeakness

Spironolactone and Fibrosis in Heart Failure Risk: Machine Learning Analysis of HOMAGE Trial Plasma Proteomics In HOMAGE, 276 plasma proteins were profiled using Olink panels. Machine learning algorithms identified galectin-9 (GAL9), thrombospondin-2 (THBS2), and NT-proBNP as predictors of changes in procolla....

#Article in @medcomm.bsky.social #MedComm
#Spironolactone and #Fibrosis in Heart Failure Risk: #MachineLearning Analysis of #HOMAGE Trial Plasma Proteomics doi.org/10.1002/mco2...

Researchers from CIMA Universidadde Navarra and IdiSNA, Spain

#biomarker #HeartFailure #MLA #PICP

A Novel Peptide, HS1002, Enhances Antitumor Activity via Dual Targeting of the GnRH Receptor and Human Telomerase Reverse Transcriptase in Prostate Cancer Cells HS1002, a new peptide targeting GnRHR and hTERT, demonstrates significant Anticancer activity in prostate cancer cells. The mechanism of HS1002 can be attributed to the reduction of serum testosteron...

#Article in #MedComm

A Novel #Peptide, #HS1002, Enhances #Antitumor Activity via Dual Targeting of the #GnRH Receptor and Human #Telomerase Reverse Transcriptase in Prostate Cancer Cells doi.org/10.1002/mco2...

Research team from Sungkyunkwan University

#hTERT #ImmuneResponse #ProstateCancer

Translational Pathways for Smart and Bioactive Dental Biomaterials: Biocompatibility Standards, Sterilisation, Sustainability and Regulation Smart and bioactive dental biomaterials can do more than replace tissue, but getting them into the clinic requires more than promising lab results. This review brings together practical requirements ...

#Review in #MedComm_Biomaterials_and_Applications
#Translational Pathways for Smart and Bioactive Dental #Biomaterials: #Biocompatibility Standards, Sterilisation, Sustainability and Regulation doi.org/10.1002/mba2...

#biocompatibility #Dental #ISO10993 #EUMDR2017_745 #ISO7405

Multifacet Roles of Cellular Senescence in Cancer: Mechanisms and Therapeutic Implications Cellular senescence shapes tumor progression through both antitumor and protumor mechanisms. Senescence triggered by telomere shortening restricts malignant transformation and limits tumor cell proli...

#Review in #MedComm_Oncology
Multifacet Roles of Cellular #Senescence in #Cancer: Mechanisms and #Therapeutic Implications doi.org/10.1002/mog2...

#SASP #ImmuneActivation

The Role of One‐Carbon Metabolism in Cancer and Its Therapeutic Significance One-Carbon metabolism in T-cell activation and tumor competition. T-cell activation shifts metabolic pathways, promoting anabolic metabolism and bioenergetic capacity. One-carbon metabolism plays a c...

#MedComm_Oncology
The Role of #One_Carbon #Metabolism in Cancer and Its Therapeutic Significance doi.org/10.1002/mog2...
Authors from Sichuan University

The #review highlights strategies to exploit specific #metabolic fragilities and proposes considerations for #biomarker-guided cancer #therapy.

Construction of a Prediction Model for Thyroid Nodules Based on Machine Learning Click on the article title to read more.

#Letter in #MedComm_Oncology

Construction of a #Prediction Model for #Thyroid #Nodules Based on #MachineLearning doi.org/10.1002/mog2...

#PapillaryThyroidCarcinoma #PTC #ArtificialIntelligence #AI

Extracellular Vesicles‐Functionalized Biomaterials for Oral Disease Theragnostics Combining EVs with biomaterials enables sustained, targeted delivery and overcomes traditional limitations. EVs show great promise in diagnosing and treating oral diseases, and could transform oral h...

#Review in #MedComm_Biomaterials_and_Applicaitonser

#Extracellular #Vesicles‐Functionalized #Biomaterials for #Oral Disease Theragnostics doi.org/10.1002/mba2...

#DrugDelivery #OralDisease #TissueEngineering

Assessing the Efficacy of Mesenchymal Stem Cell Allograft Materials in Foot and Ankle Surgery: A Systematic Review Click on the article title to read more.

#Letter in #MedComm_Biomaterials_and_Applicaitons
Assessing the Efficacy of Mesenchymal Stem Cell Allograft (#MSCA) #Materials in Foot and #Ankle Surgery: A Systematic Review doi.org/10.1002/mba2...

Authored by Dr. Mark A. Plantz from NorthWest University

#Article in #MedComm_Biomaterials_and_Applicaitons
#Myogenic Differentiation on 3D‐Printed Interpenetrating Bioactive #Hydrogel of Decellularised Human #Placenta With Fish Scale Gelatin

#bioactive #decellularization #HumanPlacenta

Chlorine‐Functionalized Nano‐Hydroxyapatite Coatings Enhance Osseointegration in Immediate Implantation by Modulating Host–Bacteria Competition This strategy employs micro-arc oxidation to construct a composite coating containing nano-hydroxyapatite (nHA) and chloride ions (Cl−), enabling dual regulation of the implant interface microenviron...

#Article in #MedComm_Biomaterials_and_Applicaitons
#Chlorine‐Functionalized #Nano‐#Hydroxyapatite Coatings Enhance #Osseointegration in Immediate #Implantation by Modulating Host–Bacteria Competition doi.org/10.1002/mba2...

#antibacterial #immediate #PeriImplantitis

Preparation and Biological Properties of Estradiol‐Cyclodextrin‐Polydopamine Functional Coating on Polypropylene Mesh Surface Schematic illustration of the preparation of E2@PDA coating on polypropylene mesh and a schematic diagram of the implantation site of a polypropylene biopatch in a female patient.

#Article in #MedComm_Biomaterials_and_Applicaitons
Preparation and #Biological Properties of #Estradiol‐#Cyclodextrin‐#Polydopamine Functional Coating on #Polypropylene Mesh Surface doi.org/10.1002/mba2...

#TissueRepair #BiologicalMeshe

Cellulose‐Based Nanocomposites in Drug Delivery and Antimicrobial Therapies: Emerging Innovations and Translational Outlook Applications of cellulose-based nanocomposites in antimicrobial drug delivery.

#Review in #MedComm_Biomaterials_and_Applications
Cellulose-Based #Nanocomposites in #DrugDelivery and #Antimicrobial Therapies: Emerging Innovations and Translational Outlook doi.org/10.1002/mba2...
Authored by researchers from #GalgotiasUniversity

#BiomedicalIntervention

#Review in #MedComm_Oncology
Molecular Glue Degraders (#MGD) Redefining #Targeted #Therapies From Discovery to Therapeutic Applications doi.org/10.1002/mog2...

#cereblon #E3UbiquitinLigase #Undruggable #reprogramming #DrugDiscovery

RNA‐Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications Ferroptosis critically influences cancer cell fate and represents a promising therapeutic strategy. Emerging evidence identifies RNA-binding proteins (RBPs) as key post-transcriptional regulators of ...

#Review in #MedComm_Oncology
#RNA-Binding Proteins (#RBP) and #Ferroptosis in #Cancer: Mechanism and Therapeutic Implications doi.org/10.1002/mog2...

#ClinicalPotential #SmallMolecule

SIRT7 Orchestrates Ligand‐Dependent ERα Signaling Rewiring to Drive Tamoxifen Resistance in ERα‐positive Breast Cancer In tamoxifen-sensitive breast cancer, SIRT7 deacetylates ERα at lysines 302 and 303, promoting CHIP-mediated, ubiquitin-dependent proteasomal degradation of ERα and thereby restraining estrogen-drive...

#Article in #MedComm_Oncology

Researchers from HunanUniversity find that #SIRT7 Orchestrates Ligand-Dependent ERα Signaling Rewiring to Drive #Tamoxifen Resistance in #ERα-positive #BreastCancer doi.org/10.1002/mog2...

#Deacetylation #DrugResistance

The Acetyl‐CoA‐NLRX1 Axis Acts as a Key Player in Mitophagy and Drug Resistance Click on the article title to read more.

#Highlight in #MedComm_Oncology
The #Acetyl-CoA-#NLRX1 Axis Acts as a Key Player in #Mitophagy and Drug #Resistance doi.org/10.1002/mog2...

The highlighted article in @nature.com ：https://doi.org/10.1038/s41586-025-09745-x

#Highlight in #MedComm_Oncology
#Metabolic Reprogramming of the Pre-Metastatic Niche: A Sweet Spot for Anti-#Tumor #Immunity doi.org/10.1002/mog2...

The highlighted article in @CellCellPress : doi.org/10.1016/j.ce...

#LowCarbohydrateDiet #Lung #Metastasis #macrophage #NKcell

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy Ageing acts as a double-edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL-6, MMPs), MDSC accumulation and T-cell suppression, fostering ....

#Review in #MedComm_Oncology
#Aging-Derived Alterations in #Genomic, #Immune, and #Metabolic Networks: Implications for Cancer Development and Therapy doi.org/10.1002/mog2...

#cancer #therapy #immunometabolism #TME

LungSurg: A Generative AI System for Segmentation and Phase Classification in Thoracoscopic Lobectomy The study introduces LungSurg, an AI system designed to assist in video-assisted thoracoscopic (VATS) lobectomy for lung cancer by accurately identifying anatomical structures and surgical phases. Th...

#Article in #MedComm
#LungSurg: A Generative #AI System for Segmentation and Phase #Classification in #ThoracoscopicLobectomy
doi.org/10.1002/mco2...

#DeepLearning #lobectomy #ThoracicSurgery #SurgicalEducation

The Gut Microbiota as a Mediator in the Relationship Between Dietary Patterns and Depression Healthy dietary patterns are associated with gut microbial genera linked to lower depressive symptoms. In 644 older adults from the PREDIMED-Plus cohort, 16S rRNA sequencing and dietary scoring revea....

#Article in #MedComm
Prof. Jordi Salas-Salvadó @JordiSalasSalva and his group revealed The #GutMicrobiota as a Mediator in the Relationship Between #Dietary Patterns and #Depression doi.org/10.1002/mco2...

#MediterraneanDiet #MicrobiomeMediation #MentalHealth #sequencing

Tumor Immunotherapy and Microbiome: From Bench‐to‐Bedside Applications The microbiome is related to the efficacy of immunotherapy and can be utilized to predict the efficacy and adverse reactions of immunotherapy. Microbiome-targeted intervention strategies can improve ....

#Review in #MedComm
Tumor Immunotherapy and Microbiome: From Bench-to-Bedside Applications doi.org/10.1002/mco2...

#Review #ICIs #Immunotherapy #microbiome #TumorMicroenvironment #TME #FMT