A new RNA therapy could help the heart repair itself after a heart attack – BioNews Central Researchers describe an RNA therapy designed to enhance the heart’s natural ability to protect and repair itself after injury. ...

Researchers describe an #RNATherapy designed to enhance the #heart’s natural ability to protect and repair itself after injury. 
#HeartDisease #HeartAttack #HeartRepair #CardiacRegeneration

New mRNA-based therapy that shows promise in heart regeneration after heart attack – BioNews Central New research demonstrates that delivering the gene PSAT1 via synthetic modified messenger RNA (modRNA) can stimulate heart muscle repair and improve cardiac function after a heart attack, marking significant progress in regenerative treatments for is

New research demonstrates that delivering the #PSAT1gene via synthetic modified #messengerRNA (#modRNA) can stimulate #HeartRepair and improve #CardiacFunction after a #HeartAttack, marking significant progress in #RegenerativeTreatments for #IschemicHeartDisease. 
#HeartDisease #CardiacRegeneration

Mitochondrial transplantation for cardioprotection and induction of angiogenesis in ischemic heart disease - Stem Cell Research & Therapy To date, the regenerative potential of mitochondrial transplantation (MT) has been extensively investigated under several pathologies. Among various cardiovascular diseases, ischemic heart disease (IH...

Exploring #MitochondrialTransplantation for cardiac repair: Recent advances reveal its role in boosting #angiogenesis & regeneration in #IschemicHeartDisease. Unraveling molecular pathways of myocardial recovery offers new hope. #HeartRepair stemcellres.biomedcentral.com/articles/10....

Engineered heart muscle allografts for heart repair in primates and humans | Nature Cardiomyocytes can be implanted to remuscularize the failing heart1–7. Challenges include sufficient cardiomyocyte retention for a sustainable therapeutic impact without intolerable side effects, such as arrhythmia and tumour growth. We investigated the hypothesis that epicardial engineered heart muscle (EHM) allografts from induced pluripotent stem cell-derived cardiomyocytes and stromal cells structurally and functionally remuscularize the chronically failing heart without limiting side effects in rhesus macaques. After confirmation of in vitro and in vivo (nude rat model) equivalence of the newly developed rhesus macaque EHM model with a previously established Good Manufacturing Practice-compatible human EHM formulation8, long-term retention (up to 6 months) and dose-dependent enhancement of the target heart wall by EHM grafts constructed from 40 to 200 million cardiomyocytes/stromal cells were demonstrated in macaques with and without myocardial infarction-induced heart failure. In

Engineered heart muscle (EHM) allografts from iPSC-derived cardiomyocytes show potential for sustainably repairing failing hearts in primates/humans. #HeartRepair PMID:39880949, Nature 2025, @Nature https://doi.org/10.1038/s41586-024-08463-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

#stemcells #heart #heartrepair

Groundbreaking!

Epigenetics News - Zebrafish protein unlocks dormant genes for heart repair bit.ly/3DGTx9P

Research from the Bakkers group at the Hubrecht Institute

#Epigenetics #HeartRepair
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