🧬 Molecule of the Moment: #mRNA4359 + #pembrolizumab
At #ESMO2025, #Moderna reported early Phase 1/2 data showing mRNA-4359 may overcome checkpoint inhibitor–resistant #melanoma by targeting #PDL1 & #IDO1 pathways. Combo with pembrolizumab showed manageable safety, no new immune AEs.

Host cell depletion of tryptophan by IFNγ-induced Indoleamine 2,3-dioxygenase 1 (IDO1) inhibits lysosomal replication of Coxiella burnetii Author summary Coxiella burnetii is a mammalian pathogen that can cause a predominantly zoonotic disease called Q-fever. In humans, Q-fever manifests as an acute or chronic illness especially in immun...

journals.plos.org/plospathogen...

"This screen demonstrated that Indoleamine 2,3-dioxygenase 1 ( #IDO1) contributes to IFNγ-mediated restriction of C. burnetii."

Host cell depletion of tryptophan by IFNγ-induced Indoleamine 2,3-dioxygenase 1 (IDO1) inhibits lysosomal replication of Coxiella burnetii Author summary Coxiella burnetii is a mammalian pathogen that can cause a predominantly zoonotic disease called Q-fever. In humans, Q-fever manifests as an acute or chronic illness especially in immun...

Host cell depletion of tryptophan by IFNγ-induced Indoleamine 2,3-dioxygenase 1 ( #IDO1) inhibits lysosomal replication of Coxiella burnetii #MECFS #LongCovid

journals.plos.org/plospathogen...